CHRNA5 rs16969968 polymorphism is associated with lung cancer risk: A meta-analysis.

Objective: To evaluate the genetic association between rs16969968 and lung cancer risk by meta-analysis.

Data Source: We searched eligible studies from MEDLINE, Web of Science and EMBASE up to Dec, 2017.

Study Selection: Association studies concerning rs16969968 and lung cancer risk were included.

Significance of cancer-associated fibroblasts in the regulation of gene expression in the leading cells of invasive lung cancer.

Purpose: Cancer-associated fibroblasts (CAFs) contribute to tumor progression through multiple pathways. However, the effect of CAFs on gene expression in lung cancer has been largely unknown. Here we systematically compared the gene expression changes in lung cancer cells induced by normal fibroblasts and CAFs.

[The relationship between the TSLC1 silencing and DNA methylation in human lung cancer cells].

Background And Objective: The expression of TSLC1 is downregulated or abrogated in many kinds of tumors, and its downregulation is highly associated with DNA hypermethlyation. The aim of this study is to explore the relationship between TSLC1 silencing and DNA methylation of its promoter region in lung cancer cells.

Methods: We detected the expression pattern of TSLC1 in human normal lung tissue and three lung cancer cell lines (A549, NCI-H446 and Calu-3) by semi-quantitative RT-PCR and Real-time PCR.

[The effect of montelukast, a leukotriene antagonist, on improvement of exercise-induced bronchoconstriction].

Objective: To study the efficacy of montelukast, a cysteinyl leukotriene receptor antagonist, in the treatment and prevention of exercise-induced bronchoconstriction (EIB) in mild asthmatic patients and patients with exercise-induced asthma (EIA).

Methods: Thirty mild asthmatic patients with positive standardized exercise challenge test were enrolled. The subjects received montelukast 10 mg once daily in the evening.

Deep cerebral venous thrombosis in adults.

Objective: To investigate the pathogenesis, clinical features, radiographic findings and therapeutic outcomes of non-acute intracranial deep venous thrombosis in adults.

Methods: Five patients who presented with increased intracranial pressure were examined with computed tomography, magnetic resonance and angiography, diagnosed as having non-acute intracranial deep venous thrombosis, and treated with thrombolytic therapy. They were reviewed retrospectively.