Molecular significance of circRNAs in malignant lymphoproliferative disorders: pathogenesis and novel biomarkers or therapeutic targets.

Recent studies have shown that circular RNAs (CircRNAs) have the novel functions and molecular mechanisms in the pathogenesis of malignant diseases. CircRNAs have been found to be associated with the occurrence and development of lymphoproliferative diseases, impacting on lymphocyte proliferation. This article provides a review of the pathogenesis of circRNAs in malignant lymphoproliferative disorders, focusing on conditions such as acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), and lymphoma.

Quantum receiver enhanced by adaptive learning.

Quantum receivers aim to effectively navigate the vast quantum-state space to endow quantum information processing capabilities unmatched by classical receivers. To date, only a handful of quantum receivers have been constructed to tackle the problem of discriminating coherent states. Quantum receivers designed by analytical approaches, however, are incapable of effectively adapting to diverse environmental conditions, resulting in their quickly diminishing performance as the operational complexities increase.

Circular RNA Controls Tumor Occurrence and Development via Cell Cycle Regulation.

Circular RNAs (circRNAs) participate in the occurrence and development of various diseases through different mechanisms, such as by acting as a microRNA (miRNA) sponge, interacting with RNA-binding proteins, and regulating gene transcription and protein translation. For example, the abnormal expression of specific circRNAs in tumor cells can alter key regulatory factors and the cell cycle network, resulting in cell cycle disorders and the development and metastasis of tumors. Here, we summarize the mechanisms involved in the circRNA-mediated processes that lead to uncontrolled cell cycle and tumor cell proliferation.

Demonstration of Entanglement-Enhanced Covert Sensing.

The laws of quantum physics endow superior performance and security for information processing: quantum sensing harnesses nonclassical resources to enable measurement precision unmatched by classical sensing, whereas quantum cryptography aims to unconditionally protect the secrecy of the processed information. Here, we present the theory and experiment for entanglement-enhanced covert sensing, a paradigm that simultaneously offers high measurement precision and data integrity by concealing the probe signal in an ambient noise background so that the execution of the protocol is undetectable with a high probability. We show that entanglement offers a performance boost in estimating the imparted phase by a probed object, as compared to a classical protocol at the same covertness level.

Identification of a novel lncRNA-miRNA-mRNA competing endogenous RNA network associated with prognosis of breast cancer.

Recently, the effects of competing endogenous RNA (ceRNA) on molecular biological mechanism of cancer have aroused great interest. In this study, long noncoding RNA-microRNA-messenger RNA (lncRNA-miRNA-mRNA) ceRNA network was screened and constructed based on the Cancer Genome Atlas (TCGA) database, and its efficacy in predicting the prognosis of breast cancer patients was evaluated. The RNA-sequencing, miRNA-sequencing, and corresponding clinical information were downloaded from the TCGA database, and differentially expressed genes were screened after data searching.

Circular RNA regulates the onset and progression of cancer through the mitogen-activated protein kinase signaling pathway.

The rapid increase in cancer morbidity and mortality worldwide is a major challenge for public health providers. Therefore, there is an urgent need to explore the molecular mechanism of tumorigenesis and identify potential diagnostic biomarkers and therapeutic methods. Circular RNA (circRNA) is characterized by a stable structure and tissue-specific expression; these features are useful in medical research and clinical applications.

The Emerging Role of Circ-SHPRH in Cancer.

Purpose: Circ-SHPRH is a circular RNA that can regulate the expression of target genes by sponging microRNAs (miRNAs) or translating tumor suppressor proteins. Recent studies have suggested that circ-SHPRH may play a role in the development of tumors and cancers. Hence, this paper aimed to review the biological characteristics, molecular mechanisms, and potential clinical significance of circ-SHPRH in a variety of tumors and to evaluate its potential as a new diagnostic and prognostic biomarker.

Entanglement-Assisted Communication Surpassing the Ultimate Classical Capacity.

Entanglement underpins a variety of quantum-enhanced communication, sensing, and computing capabilities. Entanglement-assisted communication (EACOMM) leverages entanglement preshared by communicating parties to boost the rate of classical information transmission. Pioneering theory works showed that EACOMM can enable a communication rate well beyond the ultimate classical capacity of optical communications, but an experimental demonstration of any EACOMM advantage remains elusive.

A Circular RNA Derived from Golgi Glycoprotein 1 mRNA Regulates Expression and Promotes Colorectal Cancer Progression by Targeting microRNA-622.

Background: Circular RNAs (circRNAs) represent a distinct class of non-coding RNAs that have attracted substantial research attention in recent years. We identified a novel circRNA derived from golgi glycoprotein 1 mRNA (circ_GLG1), the role of which is unknown in colorectal cancer (CRC). The purpose of this study was to explore the potential roles and mechanisms of circ_GLG1 in CRC.

Non-Coding RNAs in Diffuse Large B-Cell Lymphoma.

Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma worldwide. The molecular mechanisms underlying DLBCL have not been fully elucidated, and approximately 40% of patients who undergo standard chemoimmunotherapy still present with primary refractory disease or relapse. Non-coding RNAs (ncRNAs), a group of biomolecules functioning at the RNA level, are increasingly recognized as vital components of molecular biology.

Emerging roles of circular RNAs in colorectal cancer.

Circular RNAs (circRNAs) are a newly discovered class of endogenous non-coding RNAs. Owing to the development of high-throughput sequencing, researchers have identified thousands of circRNAs. Emerging evidence suggests that circRNAs are involved in various tumor cell processes, including proliferation, apoptosis, invasion and migration.

Efficacy of High Specific Volume Polysaccharide - A New Type of Dietary Fiber - On Molecular Mechanism of Intestinal Water Metabolism in Rats With Constipation.

BACKGROUND The aim of this study was to evaluate the effects of a new type of dietary fiber - high specific volume polysaccharide (HSVP) - on fecal properties, serum vasoactive intestinal peptide (VIP) concentration, intestinal flora count, and expression of the VIP-cAMP-PKA-AQP3 signaling pathway. MATERIAL AND METHODS Compound diphenoxylate was used in 48 healthy Wistar rats to establish a constipation model. Rats were divided into a normal control group, a constipation model group, an HSVP low-dose group, an HSVP medium-dose group, an HSVP high-dose group, and a fructose control group.

Fisher linear discriminant analysis for classification and prediction of genomic susceptibility to stomach and colorectal cancers based on six STR loci in a northern Chinese Han population.

Objective: Gastrointestinal cancer is the leading cause of cancer-related death worldwide. The aim of this study was to verify whether the genotype of six short tandem repeat (STR) loci including AR, Bat-25, D5S346, ER1, ER2, and FGA is associated with the risk of gastric cancer (GC) and colorectal cancer (CRC) and to develop a model that allows early diagnosis and prediction of inherited genomic susceptibility to GC and CRC.

Methods: Alleles of six STR loci were determined using the peripheral blood of six colon cancer patients, five rectal cancer patients, eight GC patients, and 30 healthy controls.

Current Status of Functional Studies on Circular RNAs in Bladder Cancer and their Potential Role as Diagnostic and Prognostic Biomarkers: A Review.

d_abstr_R Worldwide, bladder cancer represents the ninth most common malignancy and is the 13th cause of cancer-associated death. Although surgery combined with chemotherapy and radiotherapy has improved patient outcomes, the prognosis remains poor for most patients with muscle-invasive bladder cancer. The exact mechanisms and critical regulators of bladder cancer remain unknown.

Primary nasal diffuse large B-cell lymphoma with synchronous pulmonary involvement: A case report.

Rationale: Diffuse large B-cell lymphoma (DLBCL) is the most commonly occurring type of non-Hodgkin's lymphoma, which may be found at various extranodal sites. The nose is not a common site for DLBCL as compared with natural killer/T-cell lymphoma, and synchronous pulmonary involvement is even rarer. We report a case of primary nasal DLBCL who presented with a mass in the left lower lobe, mimicking primary lung carcinoma.

MicroRNA-related transcription factor regulatory networks in human colorectal cancer.

Objective: Colorectal cancer (CRC) is an extremely common gastrointestinal malignancy. The present study aimed to identify microRNAs (miRNAs) and transcription factors (TFs) associated with tumor development.

Methods: Three miRNA profile datasets were integrated and analyzed to elucidate the potential key candidate miRNAs in CRC.

Identification of Key Genes and Circular RNAs in Human Gastric Cancer.

BACKGROUND Globally, gastric cancer (GC) is the third most common source of cancer-associated mortality. The aim of this study was to identify key genes and circular RNAs (circRNAs) in GC diagnosis, prognosis, and therapy and to further explore the potential molecular mechanisms of GC. MATERIAL AND METHODS Differentially expressed genes (DEGs) and circRNAs (DE circRNAs) between GC tissues and adjacent non-tumor tissues were identified from 3 mRNA and 3 circRNA expression profiles.

Quantum communication based on two-mode entangled state with quantum noise locking method.

The two-mode entangled state is an important basic non-classical state and it has been used in many quantum communication projects. We propose a new quantum communication scheme with a two-mode entangled state which can transmit signals encoded by a thermal-state light field. Also, instead of locking several phases in the whole process, we use only one locking servo system at the final stage.

Ginkgo Biloba L. Extract Reduces H2O2-Induced Bone Marrow Mesenchymal Stem Cells Cytotoxicity by Regulating Mitogen-Activated Protein Kinase (MAPK) Signaling Pathways and Oxidative Stress.

BACKGROUND The oxidative stress environment of pathological tissue has an adverse effect on the survival of bone marrow mesenchymal stem cells (BMSCs) transplantation. Ginkgo biloba L. extract (EGB) has a potent antioxidant effect.

Targeted gene therapy of the fusion gene controlled by the hSLPI gene promoter of human non-small cell lung cancer .

The incidence of lung cancer and lung cancer-associated mortality have markedly increased worldwide, and gene-targeted therapy has emerged as a promising treatment strategy. The present study aimed to explore the targeted antitumor effect of the herpes simplex virus-thymidine kinase/human interleukin-12 () fusion gene regulated by the human secretory leukocyte protease inhibitor () promoter of human non-small cell lung cancer (hNSCLC). There were four recombinant eukaryotic expression vectors: pcDNA3.

MicroRNA-374b reduces the proliferation and invasion of colon cancer cells by regulation of LRH-1/Wnt signaling.

Deregulation of microRNA (miRNA) has been suggested as a critical event in colon cancer development and progression. Recent studies have suggested that miR-374b is a novel cancer-related miRNA involved in several cancer types. Thus far, very little is known about the role of miR-374b in colon cancer; therefore, the goal of this study was to investigate the potential role of miR-374b in colon cancer.

Continuous variable quantum optical simulation for time evolution of quantum harmonic oscillators.

Quantum simulation enables one to mimic the evolution of other quantum systems using a controllable quantum system. Quantum harmonic oscillator (QHO) is one of the most important model systems in quantum physics. To observe the transient dynamics of a QHO with high oscillation frequency directly is difficult.

Five-wave-packet quantum error correction based on continuous-variable cluster entanglement.

Quantum error correction protects the quantum state against noise and decoherence in quantum communication and quantum computation, which enables one to perform fault-torrent quantum information processing. We experimentally demonstrate a quantum error correction scheme with a five-wave-packet code against a single stochastic error, the original theoretical model of which was firstly proposed by S. L.

Functional Polymorphisms in COX-2 Gene Are Correlated with the Risk of Oral Cancer.

Background: This meta-analysis investigated the association between functional COX-2 gene polymorphisms and the risk of oral cancer.

Methods: Several electronic databases were searched for published studies using combinations of keywords related to COX-2 gene polymorphisms and oral cancer. After selection of relevant studies, following strict inclusion and exclusion criteria, data was performed using STATA 12.

Differential Diagnosis of Benign and Malignant Breast Tumors Using Apparent Diffusion Coefficient Value Measured Through Diffusion-Weighted Magnetic Resonance Imaging.

Objective: Apparent diffusion coefficient (ADC) value measurement of nodes in diffusion-weighted imaging was widely used in differentiating different types of human tumors. The aim of this meta-analysis was to evaluate the clinical value of ADC measurement through diffusion-weighted magnetic resonance imaging (DW-MRI) in the differential diagnosis of benign and malignant breast tumors.

Methods: Relevant studies were identified through computer-based search of databases, which were supplemented through manual search strategies.