Publications by authors named "Shuho Gotoh"
Article Synopsis
- Intracerebral hemorrhage (ICH) is a major cause of death and disability globally, with few treatment options, prompting research into the potential of stem cell therapies, specifically using bone marrow stromal cells (BMSCs) combined with scaffolds.
- The RAINBOW-Hx trial aims to evaluate the safety and effectiveness of this treatment in eight patients with chronic ICH, focusing on those with significant neurological deficits for over a year.
- The study has received ethical approval and involves detailed procedures like bone marrow extraction, cell cultivation, and various imaging assessments post-treatment to monitor patient outcomes.
Article Synopsis
- Hypoxic-ischemic brain injury, often resulting from cardiac arrest, currently lacks effective treatments, prompting research into the therapeutic potential of exosomes from mesenchymal stem cells.
- This study explores the effects of intranasally delivered exosomes in rats, using a method that allows for better concentration delivery compared to traditional intravenous methods.
- Findings show that rats receiving exosomes exhibited significant cognitive improvement and reduced brain cell death, with exosomes primarily detected in areas associated with brain function, decreasing harmful inflammation markers in the process.
Exosomes, lipid bilayer-enclosed small cellular vesicles, are actively secreted by various cells and play crucial roles in intercellular communication. These nanosized vesicles transport internalized proteins, mRNA, miRNA, and other bioactive molecules. Recent findings have provided compelling evidence that exosomes derived from stem cells hold great promise as a therapeutic modality for central nervous system disorders.
View Article and Find Full Text PDFDelayed foreign body reactions to either or both clipping and coating materials have been reported in several small series; however, studies in the titanium clip era are scarce. This study aims to survey the contemporary status of such reactions to titanium clips and coating materials. Among patients who received a total of 2327 unruptured cerebral aneurysmal surgeries, 12 developed delayed intraparenchymal reactions during outpatient magnetic resonance imaging (MRI) follow-up.
View Article and Find Full Text PDFThis report describes a case of spontaneous cerebrospinal fluid leak through a narrow canal-like fistula in the lateral wall of the sphenoid sinus, which was managed through rigid reconstruction. Rigid reconstruction of the skull base was performed by fitting a pile-shaped bone into the fistula like the pile-driving technique.
View Article and Find Full Text PDFRevascularization for internal carotid artery rupture should be considered immediately under the situation where endovascular treatment is not indicated. Revascularization can prevent the risk of hemorrhage during skull base reconstruction.
View Article and Find Full Text PDFObjectives: This study aimed to assess the clinical usefulness of a direct aspiration first pass technique as a first-line strategy for mechanical thrombectomy in posterior circulation.
Materials And Methods: We examined 34 consecutive patients treated with mechanical thrombectomy for acute vertebrobasilar artery occlusion. Procedural and clinical outcomes were assessed and compared between patients treated with a direct aspiration first pass technique first-line strategy (ADAPT group) and stent retriever system first-line strategy (stent retriever group).
Objectives: A direct first-pass aspiration technique (ADAPT) is an attractive interventional technique for mechanical thrombectomy (MT), which could achieve recanalization quickly and safely at a small amount of material resources. To clarify its usefulness, our ADAPT first-line strategy for middle cerebral artery (MCA)-mainstem occlusion was retrospectively analyzed.
Materials And Methods: We reviewed 54 consecutive patients who underwent MT for MCA-mainstem occlusion using ADAPT first-line strategy.
Background: Intracranial hematomas associated with abnormal collateral vessels are observed in certain populations of adult patients with moyamoya disease (MMD). Of these, intraventricular hematomas resulting from rupture of intraventricular aneurysms, which are formed along an abnormal peripheral choroidal artery, are sometimes detected and could be severe. No appropriate treatment option for these ruptured aneurysms has been well established to date.
View Article and Find Full Text PDFBackground: Le Fort I osteotomy, one of the most common techniques applied to correct jaw deformities, is generally considered operatively safe. However, a few articles reported that this procedure can lead to formation of arteriovenous fistulae(AVF)involving the maxillary artery infrequently.
Case Report: A man in his 40s with a jaw deformity underwent Le Fort I osteotomy.
Background: The spinal trigeminal nucleus is a cranial nerve which extends caudally from the medulla to the upper cervical segment of the spinal cord. An upper cervical lesion can cause pain or dysesthesia of the face sparing the central area, which is called onion-skin pattern.
Case Presentation: We present a rare case of a 73-year-old man with cervical ossification of the posterior longitudinal ligament(OPLL)causing onion-skin pattern dysesthesia.