Publications by authors named "Shuhei Uesugi"
Article Synopsis
- Augmenting T-cell activity is key to improving cancer immunotherapy, and inhibiting the HPK1 kinase can boost cancer immunity by enhancing T-cell receptor signaling.
- The study introduces DS21150768, a new small-molecule inhibitor of HPK1 that effectively enhances T-cell function and demonstrates strong anti-tumor effects in various mouse cancer models.
- DS21150768 is orally bioavailable and shows sustained plasma levels, leading to increased immune responses, with promising implications for future HPK1-targeted therapies and understanding tumor characteristics for treatment efficacy.
Chemoselective catalytic conjugate addition of alcohols over amines.
Angew Chem Int Ed Engl
February 2014
A highly chemoselective conjugate addition of alcohols in the presence of amines is described. The cooperative nature of the catalyst enabled chemoselective activation of alcohols over amines, allowing the conjugate addition to soft Lewis basic α,β-unsaturated nitriles. Divergent transformation of the nitrile functionality highlights the utility of the present catalysis.
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