Publications by authors named "Shuhei Hirose"
Article Synopsis
- Cancer immunotherapy, especially PD-1 blockade, is less effective in older adults due to weakened T-cell immunity, which spermidine may help restore by boosting mitochondrial fatty acid oxidation (FAO).
- Researchers developed a spermidine-based probe to identify spermidine-binding proteins and discovered 140 proteins involved, primarily in mitochondria, including key lipid metabolism proteins.
- A synthetic compound named "spermimic" was found to enhance mitochondrial bioenergetics and improve PD-1 therapy in mice, indicating potential for small-molecule cancer treatments that could boost immune responses in patients.
