Signal-On Fluorescence Biosensor for Highly Sensitive Detection of miRNA-21 Based on DNAzyme Assisted Double-Hairpin Molecular Beacon.

Although miRNAs exist in small quantities in the human body, they are closely related to the abnormal expression of genes in diseases such as tumors. Therefore, sensitive detection of miRNAs is very important for the prevention and treatment of various tumors and major diseases. The purpose of this study is to develop a label-free sensing strategy based on the co-action of double-hairpin molecular beacons and deoxyribozymes (DNAzymes) for highly sensitive detection of miRNA-21.

Gapless topological Fulde-Ferrell superfluidity in spin-orbit coupled Fermi gases.

Topological superfluids usually refer to a superfluid state which is gapped in the bulk but metallic at the boundary. Here we report that a gapless, topologically nontrivial superfluid with an inhomogeneous Fulde-Ferrell pairing order parameter can emerge in a two-dimensional spin-orbit coupled Fermi gas, in the presence of both in-plane and out-of-plane Zeeman fields. The Fulde-Ferrell pairing-induced by the spin-orbit coupling and in-plane Zeeman field-is responsible for this gapless feature.