Diverse priming outcomes under conditions of very rare precursor B cells.

Rare B cells can have special pathogen-recognition features giving them the potential to make outsized contributions to protective immunity. However, rare naive B cells infrequently participate in immune responses. We investigated how germline-targeting vaccine antigen delivery and adjuvant selection affect priming of exceptionally rare BG18-like HIV broadly neutralizing antibody-precursor B cells (~1 in 50 million) in non-human primates.

Computational design of vaccine immunogens.

Computational protein engineering has enabled the rational design of customized proteins, which has propelled both sequence-based and structure-based immunogen engineering and delivery. By discerning antigenic determinants of viral pathogens, computational methods have been implemented to successfully engineer representative viral strains able to elicit broadly neutralizing responses or present antigenic sites of viruses for focused immune responses. Combined with improvements in customizable nanoparticle design, immunogens are multivalently displayed to enhance immune responses.

Tailoring the Boron Configurations in B-doped Na V (PO ) @Carbon for Fast and Durable Sodium Storage.

Na V (PO ) (NVP) is a widely studied cathode material for sodium-ion batteries because of its high ionic conductivity and attractive charge/discharge plateau (3.4 V vs. Na/Na ).

A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity.

Saponins are potent and safe vaccine adjuvants, but their mechanisms of action remain incompletely understood. Here, we explored the properties of several saponin formulations, including immune-stimulatory complexes (ISCOMs) formed by the self-assembly of saponin and phospholipids in the absence or presence of the Toll-like receptor 4 agonist monophosphoryl lipid A (MPLA). We found that MPLA self-assembles with saponins to form particles physically resembling ISCOMs, which we termed saponin/MPLA nanoparticles (SMNP).

ZnO/CoS heterostructured nanoflake arrays vertically grown on Ni foam for high-rate supercapacitors.

Self-supported materials have been widely used in high-power energy storage devices due to the unique construction offering fast charge transfer from the active material to the conducting substrate. However, the electron conduction in the active material presents limitations on the overall performance of the electrode. In this work, we have fabricated hierarchical ZnO nanoflake arrays vertically grown on a nickel foam substrate and wrapped tightly by wrinkled porous CoS nanofilms (ZnO NFAs/CoS NFs) a hydrothermal process and subsequent electrodeposition.

Bilateral Interfaces in InSe-CoIn-CoSe Heterostructures for High-Rate Reversible Sodium Storage.

Metal selenides are considered as a group of promising candidates as the anode material for sodium-ion batteries due to their high theoretical capacity. However, the intrinsically low electrical and ionic conductivities as well as huge volume change during the charge-discharge process give rise to an inferior sodium storage capability, which severely hinders their practical application. Herein, we fabricated InSe/CoSe hollow nanorods composed of InSe/CoIn/CoSe by growing cobalt-based zeolitic imidazolate framework ZIF-67 on the surface of indium-based metal-organic framework MIL-68, followed by gaseous selenization.

SeC Bonding Promoting Fast and Durable Na Storage in Yolk-Shell SnSe @SeC.

Tin-based compounds have received much attention as anode materials for lithium/sodium ion batteries owing to their high theoretical capacity. However, the huge volume change usually leads to the pulverization of electrode, giving rise to a poor cycle performance, which have severely hampered their practical application. Herein, highly durable yolk-shell SnSe nanospheres (SnSe @SeC) are prepared by a multistep templating method, with an in situ gas-phase selenization of the SnO @C hollow nanospheres.

Mycobacterium tuberculosis proteasomal ATPase Mpa has a β-grasp domain that hinders docking with the proteasome core protease.

Mycobacterium tuberculosis (Mtb) has a proteasome system that is essential for its ability to cause lethal infections in mice. A key component of the system is the proteasomal adenosine triphosphatase (ATPase) Mpa, which captures, unfolds, and translocates protein substrates into the Mtb proteasome core particle for degradation. Here, we report the crystal structures of near full-length hexameric Mtb Mpa in apo and ADP-bound forms.