Transcriptomic analysis of the effects exerted by curcumin on dihydrotestosterone-induced ovarian granulosa cells.

Purpose: Hyperandrogenism is a leading cause of developmental retardation in ovarian granulosa cells. Previous studies have indicated that curcumin significantly improves follicular dysplasia, a characteristic of the polycystic ovary syndrome. Our purpose was to explore the signaling pathways which enable curcumin to protect the development of hyperandrogen-induced granulosa cells.