Exploring the Molecular Mechanisms and Shared Gene Signatures Between Systemic Lupus Erythematosus and Bladder Urothelial Carcinoma.

Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease associated with increased susceptibility to cancer, including bladder urothelial carcinoma (BLCA). This study investigates the shared molecular mechanisms and gene signatures between SLE and BLCA, shedding light on potential biomarkers and therapeutic targets.

Methods: We compiled gene datasets related to SLE and BLCA from various databases and identified common genes.

Simulating land use change for sustainable land management in China's coal resource-based cities under different scenarios.

Land use competition among economic development, food security and ecological protection posed challenges for the sustainable development in resource-based cities, especially those represented by coal resource-based cities in China. Predicting future land use change under the coupled framework of shared socioeconomic pathways and representative concentration pathways (SSP-RCPs) was a crucial step in devising sustainable development strategies. In this study, the patch-generated land use simulation (PLUS) model coupled with SSP-RCP scenarios (SSP126, SSP245, SSP585) was used to predict land use changes from year 2020 to 2060, identify key management regions for balancing the goals of ecological protection and food security, and propose corresponding measures.

Zhisou powder suppresses airway inflammation in LPS and CS-induced post-infectious cough model mice via TRPA1/TRPV1 channels.

Ethnopharmacological Relevance: Zhisou Powder (ZSP), a traditional Chinese medicine (TCM) prescription, has been widely used in the clinic for the treatment of post-infectious cough (PIC). However, the exact mechanism is not clear.

Aim Of The Study: The aim of this study was to investigate the ameliorative effect of ZSP on PIC in mice.

Targeting integrin α5 in fibroblasts potentiates colorectal cancer response to PD-L1 blockade by affecting extracellular-matrix deposition.

Background: One reason patients with cancer cannot benefit from immunotherapy is the lack of immune cell infiltration in tumor tissues. Cancer-associated fibroblasts (CAFs) are emerging as central players in immune regulation that shapes tumor microenvironment (TME). Earlier we reported that integrin α5 was enriched in CAFs in colorectal cancer (CRC), however, its role in TME and cancer immunotherapy remains unclear.

Long-term leaching characteristics of heavy metals from bauxite tailing slurry-based geopolymer backfill: experimental and numerical simulation studies.

This study aimed to evaluate the potential of replacing fly ash (FA) with bauxite tailing (BT) slurry for geopolymer synthesis and investigate the long-term leaching behaviour of BT slurry/FA geopolymers (BFGs) for heavy metal immobilisation. The mechanical properties and heavy metal immobilisation efficiency of BFGs were tested, and numerical simulations were conducted to assess their environmental impact as a backfill material. The results showed that the incorporation of 5 Wt.

Dual Role of Pregnane X Receptor in Nonalcoholic Fatty Liver Disease.

The incidence of nonalcoholic fatty liver disease (NAFLD) has been rising worldwide in parallel with diabetes and metabolic syndrome. NAFLD refers to a spectrum of liver abnormalities with a variable course, ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH), eventually leading to cirrhosis and hepatocellular carcinoma. Pregnane X receptor (PXR), a member of the nuclear receptor superfamily, plays a prominent part in the regulation of endogenous metabolic genes in NAFLD.

Comparative efficacy and safety of Chinese patent medicines of acute ischemic stroke: A network meta-analysis.

Background: Acute ischemic stroke (AIS) is characterized by high morbidity, disability, mortality, recurrence, and economic burden. Clinical trials have demonstrated that the clinical efficacy of combining oral Chinese patent medicines (CPMs) with chemical drugs (CDs) is better than that of CDs alone. In this study, we performed a network meta-analysis (NMA) of RCTs to assess the efficacy of different CPMs in combination with CDs in the treatment of AIS.

A two-dimensional analytical model for heavy metal contaminants transport in permeable reactive barrier.

Permeable reactive barrier (PRB) remediation technology has been widely used in the remediation of groundwater contamination. In numerical simulations, neglecting the non-uniform distribution of heavy metal contamination along the depth may lead to deviations between simulation results and reality. The distribution of heavy metals in the soil layer around a non-ferrous mining area in Hezhou, Guangxi, southern China was investigated, and it was found that the standard Gaussian function could well describe the non-uniform distribution of heavy metals in the soil layer.

Research on Adaptive Management of the Social-Ecological System of a Typical Mine-Agriculture-Urban Compound Area in North Shanxi, China.

The mine-agriculture-urban compound area formed under the combined effects of natural conditions, mineral resource endowments, and historical development is affected by severe man-made disturbances, and faces a prominent contradiction between economic development and ecological protection. Guiding the future development is an urgent problem in this region. This research used image data, logical reasoning, and empirical analysis, based on social and economic statistics and land-use data, to analyze the typical characteristics and problems of the social-ecological system in the mine-agriculture-urban compound area.

A novel microRNA, novel-m009C, regulates methamphetamine rewarding effects.

Methamphetamine (METH) is a widely abused psychostimulant, whose hyper-rewarding property is believed to underlie its addictive effect, but the molecular mechanism regulating this effect remains unclear. We previously reported that decreased expression of a novel microRNA (miRNA), novel-m009C, is implicated in the regulation of METH hyperlocomotion. Here, we found that novel-m009C may be homologous to hsa-miR-604.

The Influence of Soil Erodibility and Saturated Hydraulic Conductivity on Soil Nutrients in the Pingshuo Opencast Coalmine, China.

Soil erodibility (K factor) and saturated hydraulic conductivity (Ks) are essential indicators for the estimation of erosion intensity and can potentially influence soil nutrient losses, making them essential parameters for the evaluation of land reclamation quality. In this study, 132 soil samples from 22 soil profiles were collected to measure soil physicochemical properties (e.g.

Succession law and model of reconstructed soil quality in an open-pit coal mine dump of the loess area, China.

Studying the change laws of reconstructed soil quality and constructing succession models are the main components and tools of reconstructed soil quality evaluation for the supervision and management of reconstructed soil. However, the evaluation and management system of reconstructed soil quality suitable for the loess area needs to be improved. This paper aimed to clarify the succession law of reconstructed soil in an open-pit coal dump in the loess area on the temporal scale and to construct a succession model of reconstructed soil quality to evaluate and manage reconstructed soil.

Deciphering the origin and controlling factors of mercury in reclaimed soils: a case study in Pingshuo opencast coalmine of China.

Considering the significant influence of mercury (Hg) contamination on the land reclamation inopencast coalmine, the spatial distribution patterns and ecological risks of Hg were investigated and the regulating factors of Hg mobility were determined in the South Dump of the Pingshuo opencast coalmine. The results show that the total Hg (HgT) contents of most soil samples (83.7%) vary from 6 to 50 μg kg, while the potential ecological risk index (EI) values of most samples (79.

Changes in Reconstructed Soil Physicochemical Properties in an Opencast Mine Dump in the Loess Plateau Area of China.

Soil construction and revegetation are essential for ecological restoration in mining areas. The influence of vegetation on the horizontal and vertical distribution patterns of soil properties should be fully understood. However, most studies on reconstructed soils in mining areas only concentrate on the surface soil, without exploring the vertical variations in soil properties.

Detection of soil physical properties of reclaimed land in open-pit mining area: feasibility of application of ground penetrating radar.

In order to obtain the typical soil physical properties of reclaimed land more quickly and accurately, the South Dump of the China Coal's Antaibao Open-Pit Mine in Pingshuo was focussed on in this paper, and ground penetrating radar (GPR) technology was utilized to detect the soil physical properties of reclaimed land in the mining area. The soil profile sampling and GPR detection methods were used to acquire the data. The gravel content of surface soil was analyzed by counting the number of isolated gravel signals in GPR images.

A systematic review and meta-analysis of integrated traditional Chinese medicine and Western medicine in treating glomerulosclerosis.

Background: The combination of Traditional Chinese medicine and Western medicine (TCM+WM) has been widely used in the treatment of glomerulosclerosis, but the results are still controversial. This study will assess the clinical efficacy of TCM+WM for glomerulosclerosis and provide evidence-based medical data via meta-analysis.

Method: The MEDLINE, EMBASE, PubMed, Cochrane Central Registry of Controlled Trials, and multiple Chinese databases (Wan Fang, CNKI, and VIP) were searched for randomized controlled trials (RCT) that compared the effects of WM and TCM+WM.

Analysis of differences in chemical properties of reconstructed soil under different proportions of topsoil substitute materials.

The purpose of this study was to evaluate the soil substitutes in land reclamation following mining activities. This study revealed different reconstructed soil materials have different effects on the chemical properties of reconstructed soil and explored the appropriate proportions of reconstructed soil materials. Using topsoil, coal gangue, fly ash, and rock and soil stripping material from the Shengli Mining Area of Inner Mongolia in China as raw materials, potting experiments were carried out according to different proportions.

Pore Structure Characterization of Tailing Bed and Dewatering Mechanism at nm-µm Scales Under Shearing.

The preparation of high-density tailings is a prerequisite for cemented paste backfill technology, and the flocculated fine tailings of sealed water leads to challenges in the slurry thickening of tailings. Shearing conditions can compact the micro floc structure to improve the underflow concentration. The nm-μm scales of pore characteristics and connectivity are essential for the dewatering process.

Spatial distribution of soil bulk density and its relationship with slope and vegetation allocation model in rehabilitation of dumping site in loess open-pit mine area.

Studies of soil bulk density (BD) spatial variations of land reclaimed after mining have become a focus of land reclamation and ecological restoration research. However, there have been few studies on the relationship among the reconstructed BD, terrain conditions, and vegetation growth. We examined the southern dumping site of the Pingshuo Antaibao open-pit coal mine located in a loess area in China.

Long non-coding RNA PVT1 interacts with MYC and its downstream molecules to synergistically promote tumorigenesis.

Numerous studies have shown that non-coding RNAs play crucial roles in the development and progression of various tumor cells. Plasmacytoma variant translocation 1 (PVT1) mainly encodes a long non-coding RNA (lncRNA) and is located on chromosome 8q24.21, which constitutes a fragile site for genetic aberrations.

Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunities.

c-Met is a receptor tyrosine kinase belonging to the MET (MNNG HOS transforming gene) family, and is expressed on the surfaces of various cells. Hepatocyte growth factor (HGF) is the ligand for this receptor. The binding of HGF to c-Met initiates a series of intracellular signals that mediate embryogenesis and wound healing in normal cells.

A novel PCR-based approach to discover miRNA target genes.

MiRNAs are potent regulators of gene expression, and most miRNAs have from several to several thousands of gene targets. Validating the numerous gene targets of a given miRNA remains challenging despite the existence of various tools and databases that predict candidate gene-miRNA pairs. In the present study, we present a high-throughput but flexible method that applies a PCR-based application to simulate the binding of miRNAs to their gene targets.

[Effects of guipi pill on bone marrow cell cycle of mice exposed to benzene].

Objective: To observe the effects of Guipi Pill (GPP) on bone marrow cell cycle of mice exposed to benzene and to explore its possible mechanisms for regulating hematopoiesis.

Methods: Seventy-two Kunming mice were randomly divided into 6 groups, i.e.

[Levels of plasma interleukin-18 and interferon-gamma in patients with coronary heart disease].

Objective: To investigate the role of interleukin-18 (IL-18) and interferon-gamma (IFN-gamma) in coronary heart disease (CHD).

Methods: The levels of plasma IL-18 and IFN-gamma in 45 patients with CHD and 30 normal volunteers were determined by enzyme linked immunoadsorbent assay (ELISA). The correlation between the levels of these two cytokines and the relationship between their levels and the state of CHD were analyzed.