A Chain Entanglement Gelled SnO₂ Electron Transport Layer for Enhanced Perovskite Solar Cell Performance and Effective Lead Capture.

SnO₂ is a widely used electron transport layer (ETL) material in perovskite solar cells (PSCs), and its design and optimization are essential for achieving efficient and stable PSCs. In this study, the in situ formation of a chain entanglement gel polymer electrolyte is reported in an aqueous phase, integrated with SnO₂ as the ETL. Based on the self-polymerization of 3-[[2-(methacryloyloxy)ethyl]dimethylammonium]propane-1-sulfonic acid (DAES) in an aqueous environment, combining the catalytic effect of LiCl (as a Lewis acid) with the salting-out effect, and the introduction of polyvinylpyrrolidone (PVP) as the other polymer chain, a chain entanglement gelled SnO (G-SnO) structure is successfully constructed with a wide range of functions.

Effects of dynamic and static relaxation therapy on cancer-induced fatigue and sleep disorders in patients with breast cancer undergoing chemotherapy: a randomized control trial.

Purpose: To investigate the effects of dynamic-static combined relaxation therapy on fatigue and sleep disorders in breast cancer patients undergoing chemotherapy.

Methods: A total of 114 patients receiving chemotherapy at Tangshan People's Hospital (September 2023-June 2024) were randomly divided into three groups: control (routine nursing), experiment group 1 (static Benson relaxation), and experiment group 2 (dynamic yoga + static Benson relaxation). The intervention lasted 8 weeks.

Enhancing Methylene Blue Adsorption Performance of TiCT@Sodium Alginate Foam Through Pore Structure Regulation.

Pore structural regulation is expected to be a facile way to enhance the adsorption performance of MXene. In this work, spherical foam composites consisting of TiCT and sodium alginate (SA) were synthesized via a vacuum freeze-drying technique. By varying the solution volume of TiCT, four distinct TiCT@SA spherical foams with honeycomb-like and lamellar structures with a pore diameter in the range of 100-300 μm were fabricated.

Inhibition of the neddylation E2 enzyme UBE2M in macrophages protects against E. coli-induced sepsis.

UBE2M, an essential neddylation E2 enzyme, has been implicated in the pathogenesis of various diseases, including cancers, viral infections, and obesity. However, whether UBE2M is involved in the pathogenesis of bacterial sepsis remains unclear. In an Escherichia coli (E.

Enhanced upconversion luminescence of UCNPs@CsPbI nanocomposites via constructing multiple energy transfer channels.

The application of upconversion nanomaterials relies heavily on the ability to produce bright upconversion luminescence (UCL) or high upconversion quantum yields (UCQYs) at low power density excitation. Herein, we synthesized silica-coated NaYF:Yb@NaGdF:Tm@NaYF:Tb upconversion nanoparticles (UCNPs) and CsPbI perovskites quantum dots (PeQDs) nanocomposites by the slow hydrolysis of (3-aminopropyl)triethoxysilane. The energy transfer (ET) of Gd→Tb accelerates the five-photon upconversion process of Yb-Tm and the design of the core@shell@shell layer effectively mitigates the energy jumps between Gd ions.

Dual Interfacial Modifications by a Natural Organic Acid Enable High-Performance Perovskite Solar Cells with Lead Shielding.

Effective interfacial modification of the perovskite layer is a feasible approach to improve the efficiency and stability of perovskite solar cells (PSCs). Herein, we introduce a dual interfacial modification approach utilizing a natural organic acid, citric acid (CA), to enhance both interfaces adjacent to the crucial perovskite layer within the PSC structure. First, a CA thin layer is deposited on the top of a SnO electron transport layer to mitigate the corrosive effects of alkaline impurities in SnO on the perovskite film and to control the crystal growth of the perovskite.

SIRT1-mediated deacetylation of FOXO3 enhances mitophagy and drives hormone resistance in endometrial cancer.

Background: The complex interplay between Sirtuin 1 (SIRT1) and FOXO3 in endometrial cancer (EC) remains understudied. This research aims to unravel the interactions of deacetylase SIRT1 and transcription factor FOXO3 in EC, focusing on their impact on mitophagy and hormone resistance.

Methods: High-throughput sequencing, cell experiments, and bioinformatics tools were employed to investigate the roles and interactions of SIRT1 and FOXO3 in EC.

Optimising HIV spending in 12 eastern European and central Asian countries: a modelling study.

Background: The eastern European and central Asian (EECA) region has the fastest growing HIV epidemic globally. We aimed to identify how HIV resources could be allocated for maximum health impact.

Methods: Between Aug 1 and Dec 23, 2022, allocative efficiency analyses were undertaken for 12 countries in the EECA region (Albania, Armenia, Azerbaijan, Belarus, Georgia, Kazakhstan, Kosovo, Kyrgyzstan, Moldova, Serbia, Tajikistan, and Uzbekistan) using HIV epidemic models developed with Optima HIV.

Robust Imidazole-Linked Covalent Organic Framework Enabling Crystallization Regulation and Bulk Defect Passivation for Highly Efficient and Stable Perovskite Solar Cells.

The low crystallinity of the perovskite layers and many defects at grain boundaries within the bulk phase and at interfaces are considered huge barriers to the attainment of high performance and stability in perovskite solar cells (PSCs). Herein, a robust photoelectric imidazole-linked porphyrin-based covalent organic framework (PyPor-COF) is introduced to precisely control the perovskite crystallization process and effectively passivate defects at grain boundaries through a sequential deposition method. The 1D porous channels, abundant active sites, and high crystallization orientation of PyPor-COF offer advantages for regulating the crystallization of PbI and eliminating defects.

Impact of Personality Trait Interactions on Foraging and Growth in Native and Invasive Turtles.

Animal personalities play a crucial role in invasion dynamics. During the invasion process, the behavioral strategies of native species vary among personalities, just as the invasive species exhibit variations in behavior strategies across personalities. However, the impact of personality interactions between native species and invasive species on behavior and growth are rarely illustrated.

Engineering biomimetic silk fibroin hydrogel scaffolds with "organic-inorganic assembly" strategy for rapid bone regeneration.

Although natural polymers have been widely used in constructing bone scaffolds, it still remains challenging to fabricate natural polymer-derived bone scaffolds with biomimetic mechanical properties as well as outstanding osteogenic properties for large-size and weight-bearing bone defects regeneration. Herein, an "organic-inorganic assembly" strategy is developed to construct silk fibroin (SF)-based bone scaffolds with the aforementioned merits. After secondary structure reshuffling, the 3.

Natural Chelating Agent-Treated Electron Transfer Layer for Friendly Environmental and Efficient Perovskite Solar Cells.

In perovskite solar cells (PSCs), the electron transfer layer (ETL) characteristics have significant effects on the photoelectric conversion efficiency (PCE) of the devices. Herein, a natural chelating agent polymer polyaspartic acid (PASP) is doped into the SnO precursor solution attributed to a strong interaction between PASP molecules and SnO, which strengthens the interface contact and passivates the vacancy oxygen trap of the obtained SnO ETL, thus promoting the transfer of electrons. In addition, PASP can also regulate the growth of perovskite crystals, leading to an improved crystal quality of the perovskite films.

Neural dysfunction underlying working memory processing at different stages of the illness course in schizophrenia: a comparative meta-analysis.

Schizophrenia, as a chronic and persistent disorder, exhibits working memory deficits across various stages of the disorder, yet the neural mechanisms underlying these deficits remain elusive with inconsistent neuroimaging findings. We aimed to compare the brain functional changes of working memory in patients at different stages: clinical high risk, first-episode psychosis, and long-term schizophrenia, using meta-analyses of functional magnetic resonance imaging studies. Following a systematic literature search, 56 whole-brain task-based functional magnetic resonance imaging studies (15 for clinical high risk, 16 for first-episode psychosis, and 25 for long-term schizophrenia) were included.

Efficient DNA Coding Algorithm for Polymerase Chain Reaction Amplification Information Retrieval.

Polymerase Chain Reaction (PCR) amplification is widely used for retrieving information from DNA storage. During the PCR amplification process, nonspecific pairing between the 3' end of the primer and the DNA sequence can cause cross-talk in the amplification reaction, leading to the generation of interfering sequences and reduced amplification accuracy. To address this issue, we propose an efficient coding algorithm for PCR amplification information retrieval (ECA-PCRAIR).

Application of smart hydrogel materials in cartilage injury repair: A systematic review and meta-analysis.

Objective: Cartilage injury is a common clinical condition, and treatment approaches have evolved over time from traditional conservative and surgical methods to regenerative repair. In this context, hydrogels, as widely used biomaterials in the field of cartilage repair, have garnered significant attention. Particularly, responsive hydrogels (also known as "smart hydrogels") have shown immense potential due to their ability to respond to various physicochemical properties and environmental changes.

Pluronic F127 hydrogel-loaded extracellular vesicles from adipose-derived mesenchymal stem cells promote tracheal cartilage regeneration via SCNN1B delivery.

Extracellular vesicles (EVs) derived from adipose-derived mesenchymal stem cells (AMSC-EVs) have been highlighted as a cell-free therapy due to their regenerative capability to enhance tissue and organ regeneration. Herein, we aimed to examine the mechanism of PF127-hydrogel@AMSC-EVs in promoting tracheal cartilage defect repair. Based on bioinformatics methods, SCNN1B was identified as a key gene for the osteogenic differentiation of AMSCs induced by AMSC-EVs.

Extracellular vesicles derived from M2-like macrophages alleviate acute lung injury in a miR-709-mediated manner.

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is characterised by an uncontrolled inflammatory response, and current treatment strategies have limited efficacy. Although the protective effect of M2-like macrophages (M2φ) and their extracellular vesicles (EVs) has been well-documented in other inflammatory diseases, the role of M2φ-derived EVs (M2φ-EVs) in the pathogenesis of ALI/ARDS remains poorly understood. The present study utilised a mouse model of lipopolysaccharide-induced ALI to first demonstrate a decrease in endogenous M2-like alveolar macrophage-derived EVs.

Jianpi Gushen Huayu decoction ameliorated diabetic nephropathy through modulating metabolites in kidney, and inhibiting TLR4/NF-κB/NLRP3 and JNK/P38 pathways.

Background: Jianpi Gushen Huayu Decoction (JPGS) has been used to clinically treat diabetic nephropathy (DN) for many years. However, the protective mechanism of JPGS in treating DN remains unclear.

Aim: To evaluate the therapeutic effects and the possible mechanism of JPGS on DN.

Jian-Pi-Gu-Shen-Hua-Yu Decoction Alleviated Diabetic Nephropathy in Mice through Reducing Ferroptosis.

Background: Diabetic nephropathy (DN), one of the most frequent complications of diabetes mellitus, is a leading cause of end-stage renal disease. However, the current treatment methods still cannot effectively halt the progression of DN. Jian-Pi-Gu-Shen-Hua-Yu (JPGS) decoction can be used for the treatment of chronic kidney diseases such as DN, but the specific mechanism of action has not been fully elucidated yet.

High-efficiency upconversion luminescence in UCNPs/CsPbBr nanocomposites enhanced by silver nanoparticles.

Upconversion nanocomposites with multiple light-emitting centers have attracted great attention as functional materials, but their low efficiency limits their further applications. Herein, a novel, to the best of our knowledge, system for nanocomposites consisting of upconversion nanoparticles (UCNPs) and perovskite quantum dots (PeQDs) assembled with Ag nanoparticles (NPs) is proposed. Upconversion luminescence (UCL) operation from PeQDs is triggered by near-infrared (NIR) sensitization through Förster resonance energy transfer (FRET) and photon reabsorption (PR).

Comprehensive analysis reveals dual biological function roles of EpCAM in kidney renal clear cell carcinoma.

Background: Epithelial cell adhesion molecule (EpCAM), a well-established marker for circulating tumor cells, plays a crucial role in the complex process of cancer metastasis. The primary objective of this investigation is to study EpCAM expression in pan-cancer and elucidate its significance in the context of kidney renal clear cell carcinoma (KIRC).

Methods: Data obtained from the public database was harnessed for the comprehensive assessment of the EpCAM expression levels and prognostic and clinicopathological correlations in thirty-three types of cancer.

Shared and Distinct Neurobiological Bases of Bipolar Disorder and Attention-Deficit/Hyperactivity Disorder in Children and Adolescents: A Comparative Meta-Analysis of Structural Abnormalities.

Objective: Pediatric bipolar disorder (PBD) and attention-deficit/hyperactivity disorder (ADHD) frequently co-occur and share dysfunctions in affective and cognitive domains. As the neural substrates underlying their overlapping and dissociable symptomatology have not been well delineated, a meta-analysis of whole-brain voxel-based morphometry studies in PBD and ADHD was conducted.

Method: A systematic literature search was performed in PubMed, Web of Science, and Embase.