Spatial shifts on a hyperbolic metasurface of graphene grating/topological insulators.

We theoretically study the Goos-Hänchen (GH) and Imbert-Fedorov (IF) shifts of a reflected Gaussian beam from a hyperbolic metasurface composed of graphene grating based on topological insulators (TIs). Perturbations are generated on the surface of TIs by applying a thin magnetic film, resulting in a broken time-reversal symmetry. The GH and IF shifts are greatly enhanced as a result of the combined interaction of the graphene grating and the topological magnetoelectric effect (TME).

Association between platelet count and neonatal acute kidney injury: a cohort study using the medical information mart for intensive care III database.

Objective: A decrease in platelet count has been reported to be associated with several neonatal inflammatory diseases, including sepsis and necrotizing enterocolitis; while its association with neonatal acute kidney injury (AKI) has not been reported. This study aims to explore the association between platelet count and neonatal AKI.

Methods: This was a retrospective cohort study based on the Medical Information Mart for Intensive Care III (MIMIC-III) database.

Spatial Shifts of Reflected Light Beam on Hexagonal Boron Nitride/Alpha-Molybdenum Trioxide Structure.

This investigation focuses on the Goos-Hänchen (GH) and Imbert-Fedorov (IF) shifts on the surface of the uniaxial hyperbolic material hexagonal boron nitride (hBN) based on the biaxial hyperbolic material alpha-molybdenum (α-MoO) trioxide structure, where the anisotropic axis of hBN is rotated by an angle with respect to the incident plane. The surface with the highest degree of anisotropy among the two crystals is selected in order to analyze and calculate the GH- and IF-shifts of the system, and obtain the complex beam-shift spectra. The addition of α-MoO substrate significantly amplified the GH shift on the system's surface, as compared to silica substrate.

A high figure of merit of phonon-polariton waveguide modes with hbn/SiO/graphene /hBN ribs waveguide in mid-infrared range.

Natural hyperbolic materials can confine electromagnetic waves at the nanoscale. In this study, we propose a waveguide design that combines a high quality factor (FOM) with low loss, utilizing hexagonal boron nitride and graphene and gold substrate. The waveguide consists of a dielectric rib with a graphene layer sandwiched between two hBN ribs.

Unique ghost surface phonon polaritons in biaxially hyperbolic materials.

We predicted peculiar ghost surface phonon polaritons in biaxially hyperbolic materials, where the two hyperbolic principal axes lie in the plane of propagation. We took the biaxially-hyperbolic α-MoO as one example of the materials to numerically simulate the ghost surface phonon polaritons. We found three unique ghost surface polaritons to appear in three enclosed wavenumber-frequency regions, respectively.

Human FAM111A inhibits vaccinia virus replication by degrading viral protein I3 and is antagonized by poxvirus host range factor SPI-1.

Zoonotic poxviruses such as mpox virus (MPXV) continue to threaten public health safety since the eradication of smallpox. Vaccinia virus (VACV), the prototypic poxvirus used as the vaccine strain for smallpox eradication, is the best-characterized member of the poxvirus family. VACV encodes a serine protease inhibitor 1 (SPI-1) conserved in all orthopoxviruses, which has been recognized as a host range factor for modified VACV Ankara (MVA), an approved smallpox vaccine and a promising vaccine vector.

Spatial Multiplexed Protein Profiling of Cardiac Ischemia-Reperfusion Injury.

Background: Reperfusion therapy is critical to myocardial salvage in the event of a myocardial infarction but is complicated by ischemia-reperfusion injury (IRI). Limited understanding of the spatial organization of cardiac cells, which governs cellular interaction and function, has hindered the search for targeted interventions minimizing the deleterious effects of IRI.

Methods: We used imaging mass cytometry to characterize the spatial distribution and dynamics of cell phenotypes and communities in the mouse left ventricle following IRI.

Repurposing crizotinib to target RIPK1-dependent cell death.

Receptor-interacting protein kinase 1 (RIPK1) has emerged as a key regulator of cell death and inflammation, which are implicated in the pathogenesis of many inflammatory and degenerative diseases. RIPK1 is therefore a putative therapeutic target in many of these diseases. However, no pharmacological inhibitor of RIPK1-mediated cell death is currently in clinical use.

Dysregulation of interaction between LOX fibroblast and smooth muscle cells contributes to the pathogenesis of aortic dissection.

While cell-cell interaction plays a critical role in physiology and disease, a comprehensive understanding of its dynamics in vascular homeostasis and diseases is yet absent. Here, by use of single-cell RNA-sequencing and multi-color staining, we delineate the cellular composition and spatial characterization of human aorta with or without aortic dissection (AD). : Scrutinization of cell subtype alterations revealed significantly changed fibroblast (FB)-smooth muscle cell (SMC) interactions in AD.

Spin-splitting in a reflective beam off an antiferromagnetic surface.

A linearly-polarized radiation can be considered as the superposition of two circularly-polarized components with the same propagating direction and opposite spins. We investigated the splitting between the two spin-components in the reflective beam off the antiferromagnetic surface. The gyromagnetism and surface impedance mismatch cause the difference between the spatial shifts of the two spin-components, i.

Goos-Hänchen and Imbert-Fedorov shifts on hyperbolic crystals.

We investigated Goos-Hänchen (GH) and Imbert-Fedorov (IF) shifts on a uniaxial hyperbolic crystal, where a circularly-polarized beam was incident on the crystal from the free space. The GH- and IF-shifts were analytically obtained and numerically calculated for the hexagonal boron nitride. Our results demonstrate that the GH- and IF-shift spectra are complicated and completely different in and out the hyperbolic frequency-bands (the reststrahlen bands in the infrared region).

Unusual spin and angular momentum of Dyakonov waves at the hyperbolic-material surface.

Three Dyakonov-like polaritons (DLPs) exist at the interface between a hyperbolic material (HM) and a covering medium (CM). Each DLP is a hybridized-polarization surface polariton composed of two evanescent waves on both sides of the interface. We investigated their spin and angular momentum.

Extraordinary reflection and refraction from natural hyperbolic materials.

The reflection and refraction were theoretically investigated for a linearly-polarized wave incident upon the surface of a naturally hyperbolic material. We proposed that this material is uniaxial and possesses two hyperbolic-frequency bands (HB-I and HB-II), whose optical axis is arbitrarily pointed. We paid our attention to reflective and refractive features in the HBs and predicted some extraordinary phenomena.

The Clinicopathological and Prognostic Significance of IDO1 Expression in Human Solid Tumors: Evidence from a Systematic Review and Meta-Analysis.

Background/aims: Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme-containing enzyme catalyzing the initial and rate-limiting steps in the kynurenine pathway, which converts tryptophan into kynurenine. Upregulation of IDO1 decreases tryptophan levels and increases the accumulation of kynurenine and its metabolites. These metabolites can affect the proliferation of T cells.

Author Correction to: Recent Perioperative Pharmacological Prevention of Acute Kidney Injury after Cardiac Surgery: A Narrative Review.

Acute kidney injury (AKI) is a common and severe complication of cardiac surgery, and related rates of both hospitalization and long-term mortality are increasing. A number of studies have explored the preventive effects of perioperative pharmacological therapy on AKI after cardiac surgery.

Correction: Aliskiren therapy in hypertension and cardiovascular disease: a systematic review and a meta-analysis.

[This corrects the article DOI: 10.18632/oncotarget.19382.

Correction: The optimal time of initiation of renal replacement therapy in acute kidney injury: A meta-analysis.

[This corrects the article DOI: 10.18632/oncotarget.17946.

Generation of Elliptically Polarized Terahertz Waves from Antiferromagnetic Sandwiched Structure.

The generation of elliptically polarized electromagnetic wave of an antiferromagnetic (AF)/dielectric sandwiched structure in the terahertz range is studied. The frequency and external magnetic field can change the AF optical response, resulting in the generation of elliptical polarization. An especially useful geometry with high levels of the generation of elliptical polarization is found in the case where an incident electromagnetic wave perpendicularly illuminates the sandwiched structure, the AF anisotropy axis is vertical to the wave-vector and the external magnetic field is pointed along the wave-vector.

High Difference-Frequency Generation in SiO₂/MnF₂/Ag Sandwich Structures.

In this work, a simple antiferromagnetic (AF) sandwich structure is proposed to increase the difference-frequency (DF) outputs, where a noble metal, Ag layer, is put under an AF film. Numerical calculations are based on the SiO2/MnF2/Ag sandwich structure, where MnF2 is a typical AF material. We found that the DF outputs on the above surface are increased at least two orders which compared with those of MnF2 film.

Aliskiren therapy in hypertension and cardiovascular disease: a systematic review and a meta-analysis.

The efficacy and safety of aliskiren combination therapy with angiotensin converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) in patients with hypertension and cardiovascular disease remains attractive attention. We searched the Cochrane Central Register, the Clinical Trials Registry, EMBASE, MEDLINE and PubMed for relevant literatures up to January 2017. A total of 13 randomized controlled trials (RCTs) with 12222 patients were included in this study, and the combined results indicated that aliskiren in combination therapy with ACEIs or ARBs had remarkable effects in reducing systolic blood pressure (SBP) [weighted mean differences (WMD), -4.

The optimal time of initiation of renal replacement therapy in acute kidney injury: A meta-analysis.

Background: The impact on the timing of renal replacement therapy (RRT) initiation on clinical outcomes for patients with acute kidney injury (AKI) remains controversial.

Materials And Methods: We searched the Cochrane Library, EMBASE, Global Health, MEDLINE, PubMed, the International Clinical Trials Registry Platform, and Web of Science.

Results: We included 49 studies involving 9698 patients.

Recent Perioperative Pharmacological Prevention of Acute Kidney Injury after Cardiac Surgery: A Narrative Review.

Acute kidney injury (AKI) is a common and severe complication of cardiac surgery, and related rates of both hospitalization and long-term mortality are increasing. A number of studies have explored the preventive effects of perioperative pharmacological therapy on AKI after cardiac surgery. However, the mechanisms of AKI are multifaceted, and no universal treatment has been confirmed as beneficial.