Publications by authors named "Shufan Wu"

Introduction: Systemic lupus erythematosus (SLE) complicated by thrombotic microangiopathy (TMA) and non-cirrhotic portal hypertension (NCPH) is rare. We present a case of a female patient with SLE who developed TMA and NCPH and responded positively to rituximab and plasma exchange treatment.

Case Description: A 53-year-old woman was admitted with 6 h of confusion.

View Article and Find Full Text PDF
Article Synopsis
  • Axial spondyloarthritis (axSpA) is often diagnosed late in HLA-B27-negative patients, leading to missed treatment opportunities, prompting the development of an AI tool called NegSpA-AI to improve diagnosis using MRI and clinical features.
  • The study analyzed data from 454 HLA-B27-negative patients, using various MRI techniques and applying deep learning for axSpA versus non-axSpA differentiation, split across training and testing groups.
  • NegSpA-AI outperformed junior rheumatologists in diagnostic accuracy, demonstrated by high areas under the curve in multiple test sets, and significantly improved the performance of radiologists when used as an assistive tool.
View Article and Find Full Text PDF

Designing multifunctional materials that mimic the light-dark decoupling of natural photosynthesis is a key challenge in the field of energy conversion. Herein, we introduce MnBr-253, a precious metal-free metal-organic framework (MOF) built on Al nodes, bipyridine linkers and MnBr(CO)(bipyridine) complexes. Upon irradiation, MnBr-253 colloids demonstrate an electron photocharging capacity of ~42 C ⋅ g , with state-of-the-art photocharging rate (1.

View Article and Find Full Text PDF

The treatment of primary Sjögren's syndrome (pSS) coexisting with neuromyelitis optica spectrum disorder (NMOSD) using protein-A immunoadsorption combined with immunosuppressive therapy has rarely been reported. Herein, we present the case of a 35-year-old female diagnosed with pSS concomitant with NMOSD (pSS-NMOSD) who demonstrated a positive response to protein-A immunoadsorption after failing to respond to therapy comprising high-dose intravenous methylprednisolone (IVMP) and intravenous immunoglobulin (IVIG). Within one week of receiving three sessions of immunoadsorption combined with immunosuppressive treatment, the patient's clinical symptoms (blurred vision, paraparesis, and dysfunctional proprioception) significantly improved.

View Article and Find Full Text PDF

Objectives: Cyclophosphamide (CYC) was commonly used to treat autoimmune disorders, and it could also cause side effects such as intestinal damage. This study aimed to explore the mechanism of CYC-induced intestinal cytotoxicity and provide evidence for protecting from intestinal damage by blocking TLR9/caspase3/GSDME mediated pyroptosis.

Methods: Intestinal epithelial cells (IEC-6) were treated with 4-hydroxycyclophosphamide (4HC), a key active metabolite of CYC.

View Article and Find Full Text PDF

Axial spondyloarthritis (Ax-SpA) is a chronic inflammatory disease that predominantly affects the axial joints and is most common in young men. However, the precise immune cell subset involved in Ax-SpA remains unclear. Our study characterized the periphery immune landscape of Ax-SpA patients before and after anti-TNFα treatment using single-cell transcriptomics and proteomics sequencing and elucidated the effects of anti-TNFα treatment at the single-cell level.

View Article and Find Full Text PDF

Activation of multiple inflammasomes in monocytes/macrophages is associated with the pathogenesis of systemic lupus erythematosus (SLE). Gasdermin D (GSDMD)-mediated pyroptosis, a common consequence of multiple activated inflammasomes, is a programmed cell death with strong inflammatory responses. This suggested that targeting monocyte/macrophage pyroptosis might provide an opportunity to cure SLE.

View Article and Find Full Text PDF
Article Synopsis
  • Increasing interest in solid micro-particles impacts fields like space debris protection and cold-spray manufacturing due to their behavior upon impact.
  • A new motion monitoring solution is introduced using advanced imaging technology, which utilizes a specialized camera and LED flashes to capture high-speed particle movement.
  • The method can theoretically achieve 1 million frames per second and effectively track tiny particles moving at speeds up to 12 km/s, confirmed through various experiments.
View Article and Find Full Text PDF
Article Synopsis
  • Microsatellites are gaining attention due to their portability and distribution, leading to a focus on developing effective ground stations to support their service.* -
  • The paper presents a networked ground station with multiple nodes that collaborate for efficient data transmission, utilizing a cloud computing model for coordination.* -
  • On-orbit experiments validate the design, demonstrating strong data transmission performance and successful completion of the satellite mission.*
View Article and Find Full Text PDF

Metallic Na (K) are considered a promising anode materials for Na-metal and K-metal batteries because of their high theoretical capacity, low electrode potential, and abundant resources. However, the uncontrolled growth of Na (K) dendrites severely damages the stability of the electrode/electrolyte interface, resulting in battery failure. Herein, a heterogeneous interface layer consisting of metal vanadium nanoparticles and sodium sulfide (potassium sulfide) is introduced on the surface of a Na (K) foil (i.

View Article and Find Full Text PDF

Objective: To determine the role of gasdermin E (GSDME)-mediated pyroptosis in the pathogenesis and progression of rheumatoid arthritis (RA), and to explore the potential of GSDME as a therapeutic target in RA.

Methods: The expression and activation of caspase 3 and GSDME in the synovium, macrophages, and monocytes of RA patients were determined by immunohistochemistry, immunofluorescence, and Western blot analysis. The correlation of activated GSDME with RA disease activity was evaluated.

View Article and Find Full Text PDF

In this study, submillimeter level accuracy K-band microwave ranging (MWR) equipment is demonstrated, aiming to verify the detection of the Earth's gravity field (EGF) and digital elevation models (DEM), through spacecraft formation flying (SFF) in low Earth orbit (LEO). In particular, this paper introduces in detail an integrated BeiDou III B1C/B2a dual frequency receiver we designed and developed, including signal processing scheme, gain allocation, and frequency planning. The receiver matched the 0.

View Article and Find Full Text PDF

Currently, high strength nacre-inspired PVA/MMT (polyvinyl alcohol/montmorillonite) nanocomposites with high MMT nanofiller content (50-70 wt%) have been constructed successfully. However, this seriously sacrifices the elongation and reduces the corresponding transparency. In this paper, high elongation and transparent PVA/MMT nanocomposites with high MMT content are prepared by the evaporation-induced assembly with the introduction of the micro-crosslinking.

View Article and Find Full Text PDF

Spacecraft formation flying (SFF) in highly elliptical orbit (HEO) has attracted much attention since many applications in space explore, while precise guidance navigation and control (GNC) technology, especially precise ranging, conducted the basis of success for such SFF missions. In this paper, we introduced a novel K band microwave ranging (MWR) equipment that aimed for the on-orbit verification of submillimeter level precise ranging technology in future HEO SFF missions. The ranging technique is a synchronous dual one-way ranging (DOWR) microwave phase accumulation system, which achieved tens of microns of ranging accuracy in laboratory environment.

View Article and Find Full Text PDF

Currently, it appears that there is a lack of understanding related to the role of SSF, in the two-phase behavior of the deceleration history, which is an issue discussed recently in the impact dynamics field. This paper analytically and numerically focuses on the effect of SSF on the projectile deceleration characteristic of concrete-like targets. Firstly, the penetration process according to the two-phase feature of the projectile deceleration is revised, where analytical results indicate that the SSF has a phased feature corresponding to the two-phase behavior of the deceleration history.

View Article and Find Full Text PDF
Article Synopsis
  • * This study explores HCQ's role in inhibiting dendritic cell (DC) maturation and migration, revealing that HCQ reduces key markers and cytokine levels in DCs when exposed to RA patient serum.
  • * Mechanistically, HCQ works by down-regulating TLR9 expression in DCs, which is linked to decreased inflammation and improved AR scores, indicating that modulating DC activation can help alleviate RA symptoms.
View Article and Find Full Text PDF

For the attitude stabilization of spacecraft with actuator dynamics, this paper proposed a finite-time control law. Firstly, the dynamic property of the actuator is analyzed by an example. Then, a basic control law is derived to achieve the finite-time stability using the double fast terminal sliding mode manifold.

View Article and Find Full Text PDF

Fish oil, which contains omega-3 fatty acids mainly in the form of triglycerides, has benefits for reducing breast cancer risk, similar to tamoxifen action. However, it remains to be elucidated whether the combination of omega-3 free fatty acid (ω-3FFA) with tamoxifen leads to improved treatment in breast cancer. In this study, we observed that ω-3FFA induces MCF-7 cell apoptosis to suppress cell growth.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_session70aag9egss8mrjjicelt0ll98t1ajgci): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once