Safranal acts as a neurorestorative agent in rats with cerebral ischemic stroke via upregulating SIRT1.

Safranal is an active ingredient of saffron (.). Its neuroprotective role in ischemic stroke (IS) through reducing oxidative stress damage has been widely reported.

Collagen XXIV (Col24α1) promotes osteoblastic differentiation and mineralization through TGF-β/Smads signaling pathway.

Collagen XXIV (Col24α1) is a recently discovered fibrillar collagen. It is known that mouse Col24α1 is predominantly expressed in the forming skeleton of the mouse embryo, as well as in the trabecular bone and periosteum of the newborn mouse. However, the role and mechanism of Col24α1 in osteoblast differentiation and mineralization remains unclear.