Docetaxel-Loaded Electrospun Nanofibrous Mats for Local Chemotherapy Targeting Positive Surgical Margins in Prostate Cancer.

Positive surgical margins following radical prostatectomy significantly contribute to tumor recurrence. While systemic chemotherapy demonstrates limited efficacy in this context, local chemotherapy drug delivery systems based on nanomaterials offer promising strategies to address this issue by modifying drug release kinetics and distribution, thereby enhancing antitumor effects while minimizing the toxicities associated with systemic chemotherapy. In this study, we utilized electrospun nanofibrous mats loaded with docetaxel for sustained drug delivery.

Rapid clonal expansion and somatic hypermutation contribute to the fate of SARS-CoV-2 broadly neutralizing antibodies.

Several vaccines and immunization strategies, including inactivated vaccines, have proven effective in eliciting antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), providing an opportunity to characterize the antibody response. In this study, we investigated the monoclonal antibody responses elicited by wild-type SARS-CoV-2 inactivated vaccination compared to those elicited by natural infection and mRNA vaccination. The analysis showed that antibodies encoded by biased germline genes were shared between SARS-CoV-2 vaccinated and naturally infected individuals.

Postoperative adhesions are abrogated by a sustained-release anti-JUN therapeutic in preclinical models.

Postoperative abdominal adhesions are the leading cause of bowel obstruction and a cause of chronic pain and infertility. Adhesion formation occurs after 50 to 90% of abdominal operations and has no proven preventative or treatment strategy. Abdominal adhesions derive primarily from the visceral peritoneum and are composed of polyclonally proliferating tissue-resident fibroblasts.

Y chromosome-linked UTY modulates sex differences in valvular fibroblast methylation in response to nanoscale extracellular matrix cues.

Aortic valve stenosis (AVS) is a progressive disease, wherein males more often develop valve calcification relative to females that develop valve fibrosis. Valvular interstitial cells (VICs) aberrantly activate to myofibroblasts during AVS, driving the fibrotic valve phenotype in females. Myofibroblasts further differentiate into osteoblast-like cells and produce calcium nanoparticles, driving valve calcification in males.

Liquid-bodied antibiofilm robot with switchable viscoelastic response for biofilm eradication on complex surface topographies.

Recalcitrant biofilm infections pose a great challenge to human health. Micro- and nanorobots have been used to eliminate biofilm infections in hard-to-reach regions inside the body. However, applying antibiofilm robots under physiological conditions is limited by the conflicting demands of accessibility and driving force.

Conditioned medium of engineering macrophages combined with soluble microneedles promote diabetic wound healing.

Diabetic wounds have a profound effect on both the physical and psychological health of patients, highlighting the urgent necessity for novel treatment strategies and materials. Macrophages are vital contributors to tissue repair mechanisms. Macrophage conditioned medium contains various proteins and cytokines related to wound healing, indicating its potential to improve recovery from diabetic wound.

Biodetoxification of both AFB1 and ZEN by Bacillus subtilis ZJ-2019-1 in gastrointestinal environment and in mice.

Aflatoxin B1 (AFB1) and zearalenone (ZEN) are the most prevalent mycotoxins in production, posing a serious threat to human and animal health. Therefore, it is very urgent to find a safe and efficient method for the biodegradation of these mycotoxins. Our previous study demonstrated that Bacillus subtilis ZJ-2019-1 moderately degrades both mycotoxins in vitro and ZEN in female gilts.

Promoter Methylation of WIF1 is Involved in IL-17-Induced Chondrocyte Inflammatory Injury and Matrix Degradation via Promoting Wnt5a/MAPK-JNK Signaling.

The activity of Wnt inhibitory factor 1 (WIF1) is reduced upon promoter methylation and is involved in cartilage degradation in osteoarthritis. This study aims to investigate the mechanism by which WIF1 methylation is involved in chondrocyte damage in ankylosing spondylitis (AS). A model of chondrocyte inflammatory injury in AS was constructed by stimulation with interleukin (IL)-17.

The relationship between time perspective and fear of cancer recurrence among Chinese gastric cancer patients: the chain mediating role of rumination and catastrophizing.

Purpose: Gastric cancer patients often experience significant fear of recurrence, impacting their physical and mental health. This study explores how time perspective influences fear of cancer recurrence, considering the roles of intrusive rumination and catastrophizing.

Methods: A cross-sectional design was employed with 394 gastric cancer patients.

MAZ-mediated LAMA5 transcription activation promotes gastric cancer progression through the STAT3 signaling.

Laminin subunit alpha-5 (LAMA5) has been identified as an oncogene in many cancers, while its role and mechanism in gastric cancer (GC) remain to be explored. Here, the influences of LAMA5 knockdown on GC were investigated in vitro and in vivo. LAMA5 expression was silenced in GC cells alone or in combination with the signal transducer and activator of transcription 3 (STAT3) activator Colivelin, followed by CCK-8, colony formation, EdU, flow cytometry, wound healing assay, and Transwell assay.

The association between lactating behaviours and postpartum weight retention during the 'Zuòyuèzi' period in China: a multicentre mother-infant cohort study.

Background: Few studies have examined the association between lactating behaviors and postpartum weight retention (PPWR) during the 'Zuòyuèzi' period, a traditional Chinese postpartum confinement practice that typically occurs within the first month after delivery. This study aimed to examine the association between breastfeeding practices (exclusive vs. mixed feeding) and PPWR during the Zuòyuèzi period; and to explore the feasibility of the new latent category variable derived from latent class analysis (LCA) reflecting lactating experience and quality.

Genome-wide identification of the SmPHR gene family in Salvia miltiorrhiza and SmPHR7-mediated response to phosphate starvation in Arabidopsis thaliana.

This study reveals the transcripts of S. miltiorrhiza in response to phosphate deficiency, identifies 18 SmPHRs in the genome, and tentatively establishes a role for SmPHR7 in regulating phosphate starvation. Phosphorus is essential for plant growth and development, and phosphate deficiency is a common nutritional stress.

Long noncoding RNA MATN1-AS1 contributes to oxaliplatin resistance of gastric cancer cells through miR-518b/ZNF281 axis.

Chemoresistance leads to poor outcomes of patients with gastric cancer (GC). Long non-coding RNAs (lncRNAs) have been demonstrated as novel gene modulators in various carcinomas and chemoresistance. Our study aimed to investigate the role and underlying modulatory mechanism of lncRNA MATN1-AS1 in GC chemoresistance.

Protein-ligand interaction prediction based on heterogeneity maps and data enhancement.

Prediction of protein-ligand interactions is critical for drug discovery and repositioning. Traditional prediction methods are computationally intensive and limited in modeling structural changes. In contrast, data-driven deep learning methods significantly reduce computational costs and offer a more efficient approach for drug discovery.

Multi-omics uncover acute stress vulnerability through gut-hypothalamic communication in ducks.

1. The avian gut hosts a complex and dynamic microbial ecosystem, which is essential for regulating host organ function. However, the relationship between the gut microbiota and the hypothalamic axis in acute stress vulnerability in ducks remains unclear.

Electronic Configuration-Modulated Dual-Active Nanocomposite NiAlO for Promoting Plastic-To-Green Hydrogen.

Chemical upcycling of plastic waste to produce green H has emerged as a promising avenue. Highly efficient and robust NiAlO catalysts with dual active nanocomposite (NiO-NiAlO) through a facile electronic configuration modulation strategy are synthesized for the decomposition-catalytic steam reforming (DCSR) of plastic wastes for enhancing H production while alleviating carbon deposition. Of these dual-active nanocomposite catalysts, NiAlO-800 presents the highest proportions of Ni cations and oxygen vacancies, contributing to the enhance structural stability and catalytic activity.

Negative Enthalpy Doping Stabilizes P2-Type Oxides Cathode for High-Performance Sodium-Ion Batteries.

P2-type NaNiMnO (NNMO) as cathode material for sodium-ion batteries (SIBs) largely suffers from continuous accumulation of local stress caused by destructive structural evolution and irreversible oxygen loss upon cycling, leading to rapid capacity degradation. Herein, a strategy of negative enthalpy doping (NED), wherein transition metal (TM) sites are substituted with 0.01 mol each Sn, Sb, Cu, Ti, Mg, and Zn to increase the stability of the TM layers, is proposed.

10% carbon dioxide improves cognitive function after subarachnoid hemorrhage in rats: inhibiting neuronal apoptosis through the PI3K/AKT signaling pathway.

Many patients experience long-term cognitive dysfunction after subarachnoid hemorrhage (SAH), and effective treatments are currently lacking. Carbon dioxide (CO2), an inexpensive and easily produced gas, forms carbonic acid when dissolved in water. Studies have suggested that hypercapnia may have neuroprotective effects.

Exploration of a modified pretreatment process coupled with GC-MS/MS for determination of 18 phthalates in edible oils.

Phthalates (PAEs), which are pollutants that most easily migrate from plastic packages to edible oils, have received increasing attention. In this work, a sample preconditioning method was proposed and explored, involving a single-step extraction using a methanol and ethyl hexanoate mixed solvent, followed by clean-up with a mixed absorbent of graphitic carbon nitride (g-CN) and -propyl ethylenediamine (PSA), for the determination of 18 PAEs in oil samples through GC-MS/MS analysis. The triazine ring structure and conjugated aromatic heterocyclic accumulation structure of g-CN and the amino-rich structure of PSA can provide hydrogen bonds, conjugated π-π interactions, and hydrophobic effects for the removal of interferences such as organic acids, aliphatic acids, and pigments.

Microwave Absorption Properties of Graphite Nanosheet/Carbon Nanofiber Hybrids Prepared by Intercalation Chemical Vapor Deposition.

Carbon-based microwave absorption materials have garnered widespread attention as lightweight and efficient wave absorbers, emerging as a prominent focus in the field of functional materials research. In this work, FeNi nanoparticles, synthesized in situ within graphite interlayers, were employed as catalysts to grow carbon nanofibers in situ via intercalation chemical vapor deposition (CVD). We discovered that amorphous carbon nanofibers (CNFs) can exfoliate and separate highly conductive graphite nanosheets (GNS) from the interlayers.

Fluorescence Quenching of Graphene Quantum Dots from Orange Peel for Methyl Orange Detection.

Methyl orange (MO) is an organic synthetic dye widely used in laboratory and industrial applications. In laboratory settings, it serves as an acid-base indicator due to its distinct color change in both acidic and alkaline environments. Industrially, it is primarily utilized in the textile industry for its ultraviolet (UV) absorption properties.

Picolinamide Functionalization on Carbon Nitride Edges for Enhanced Charge Separation and Photocatalytic Hydrogen Evolution.

The periodical distribution of N and C atoms in carbon nitride (CN) not only results in localized electrons in each tri-s-triazine unit, but oxidation and reduction sites are in close contact spatially, resulting in severe carrier recombination. Herein, the hydrothermal method was first employed to synthesize carbon nitride (HCN), and then picolinamide (Pic) molecules were introduced at the edge of the carbon nitride so that the photo-generated electrons of the whole structure of the carbon nitride system were transferred from the center to the edge, which effectively promoted the separation of photo-generated carriers and inhibited the recombination of carriers in the structure. The introduced picolinamide not only changed the π-conjugated structure of the entire system but also acted as an electron-withdrawing group to promote charge transfer.

High-Breakdown and Low-Leakage 4H-SiC MOS Capacitor Based on HfO/SiO Stacked Gate Dielectric in Trench Structures.

The progression of SiC MOSFET technology from planar to trench structures requires optimized gate oxide layers within the trench to enhance device performance. In this study, we investigated the interface characteristics of HfO and SiO/HfO gate dielectrics grown by atomic layer deposition (ALD) on SiC trench structures. The trench structure morphology was revealed using scanning electron microscopy (SEM).

Soft, Stretchable, High-Sensitivity, Multi-Walled Carbon Nanotube-Based Strain Sensor for Joint Healthcare.

Exoskeletons play a crucial role in joint healthcare by providing targeted support and rehabilitation for individuals with musculoskeletal diseases. As an assistive device, the accurate monitoring of the user's joint signals and exoskeleton status using wearable sensors is essential to ensure the efficiency of conducting complex tasks in various scenarios. However, balancing sensitivity and stretchability in wearable devices for exoskeleton applications remains a significant challenge.

Research Progress on the Immune Function of Liver Sinusoidal Endothelial Cells in Sepsis.

Sepsis is a complex clinical syndrome closely associated with the occurrence of acute organ dysfunction and is often characterized by high mortality. Due to the rapid progression of sepsis, early diagnosis and intervention are crucial. Recent research has focused on exploring the pathological response involved in the process of sepsis.