An excimer process induced a turn-on fluorescent probe for detection of ultra-low concentration of mercury ions.

The accumulation of mercury pollution in plants can induce severe injury to human beings. It is a great challenge to monitor ultra-low concentrations of mercury in complicated matrixes. In this study, we successfully developed a strategy Hg-triggered naphthalene-based fluorescent probe 1, which formed excimer that subsequently emitted fluorescence for the successful detection of ultra-low concentrations of Hg.

Coordination Synergistic-Induced -Aggregation Enhanced Fluorescent Performance of HBT-Excimers and Imaging Applications.

Developing a novel strategy to improve the optical performances of fluorescent probes is a vital factor in elevating its practical application; viz., novel biocompatible fluorescent probes with excellent multifunctions exhibited unparalleled advantages in probing functions of intracellular molecules to elucidate intracellular events in living systems. Herein, we have successfully constructed a new strategy that aggregation and coordination synergistically induce (2-hydroxylphenyl-benzothiazole) HBT derivatives to form excimers with large red-shifted fluorescence and application for insight into stress-response zinc fluctuations in living systems.

Development of fluorescent probes with specific recognition moiety for hydrogen polysulfide.

Hydrogen polysulfide (HS, n > 1) is an important component of reactive sulfur species (RSS), which is an important substance for maintaining the redox balance in cells. However, limited recognition moieties are available for hydrogen polysulfide probe design. In this study, we have constructed a small library containing several organic molecules to explore a new specific recognition moiety for HS fluorescent probe design.

A small molecule fluorescent probe for mercury ion analysis in broad low pH range: Spectral, optical mechanism and application studies.

Development of new fluorescent probes for mercury ion analysis in environmental or living organism is undergoing quick growth due to its detrimental toxicity to environmental safety, ecological security, and human being. However, in most cases, the industrial waste water is acidic whereas it remains a great challenge to real-time monitor mercury ion directly at low pH using small molecule fluorescence probe. In this study, we have successfully designed and synthesized the Naph (1, 8-Naphthalimide derivative) -based small molecule probe termed as Naph-NSS capable of monitoring mercury ion in a broad range at low pH (from 2.

Insight into sulfur dioxide and its derivatives metabolism in living system with visualized evidences via ultra-sensitive fluorescent probe.

Sulfur dioxide (SO) and its derivatives have long been considered as hazardous environmental pollutants but commonly used as food additives in safe dose range. They also could be produced from biological metabolism process of sulfur-containing amino acids. However, their physiological roles remain extremely obscure mainly due to lack of efficient tools for monitoring and imaging strategy establishment.

A cysteine-selective fluorescent probe for monitoring stress response cysteine fluctuations.

Rare studies provided evidence for the real-time monitoring of stress response cysteine fluctuations. Here, we have successfully designed and synthesized a cysteine-selective fluorescent probe 1 to monitor stress response Cys fluctuations, providing visual evidence of Hg2+ regulated cysteine fluctuations for the first time, which may open a new way to help researchers to reveal the mechanism of heavy metal ion poisoning.

A chemical covalent tactic for bio-thiol sensing and protein labeling agent design.

Discovering novel chemical reactions is important for bioanalysis. Herein, we report a tactic for bio-thiol sensing and protein labeling agent design by the installation of a sulfoxide group onto the skeleton of various fluorophores, and powerfully validate its abilities, which may shed light on the development of specific protein tags to give insight into their biological functions.

A reaction-based ratiometric fluorescent probe for mercury ion detection in aqueous solution.

Mercury ions are crucially harmful to ecosystem and human being due to their characters of bioaccumulation and difficulty of biochemical degradation. Therefore, development of mercury ion detection methods has attracted increasing interests recently. In this study, we successfully synthesized a hydroxyphenylbenzothiazole (HBT)-based fluorescent probe HBT-Hg in an extremely simple manner for mercuric ions detection.

A colorimetric method for determination of the prostate specific antigen based on enzyme-free cascaded signal amplification via peptide-copper(II) nanoparticles.

Biotinylated peptide-Cu nanoparticles (Cu-P NPs) were synthesized via "one-pot" self-assembly. The peptide P conststs of a hydrophobic dipeptide (FF), a tripeptide (KGH), and a biotin moiety attached to the terminal amino group of the Lys residue. The Cu-P NPs contain abundant catalytically active Cu ions which are liberated by acid-induced dissolution.

A novel ratiometric AIEE/ESIPT probe for palladium species detection with ultra-sensitivity.

Existing fluorescent probes for palladium (Pd) species detection have revealed their vulnerabilities, such as low sensitivity, poor anti-interference ability and long reaction time. In order to develop a faster and more accurate detection method for palladium species at extremely low concentrations, in this study, we designed a novel ratiometric AIEE/ESIPT probe (HPNI-1) based on the Tsuji-Trost reaction for Pd. According to the data obtained, the probe was able to detect Pd species with an ultra-high anti-interference ability (Pd : other metals = 1 : 1000), rapid detection time (within 2 minute) and ratiometric fluorescent signal changes with a 1.

A ratiometric fluorescent probe of methionine sulfoxide reductase with an improved response rate and emission wavelength.

A ratiometric fluorescent probe of methionine sulfoxide reductase, Msr-Ratio, was disclosed for monitoring the enzyme activity in vitro and in live cells. The probe displayed favorable properties such as a nearly 400-fold fluorescence change, fast response rate (<30 min), large Stokes shift (120 nm), and green emission (550 nm).

Recovery of uranium(VI) from aqueous solution by 2-picolylamine functionalized poly(styrene-co-maleic anhydride) resin.

A 2-picolylamine functionalized poly(styrene-co-maleic anhydride) resin was synthesized and characterized by FT-IR, elemental analysis, SEM and XPS. To recover uranium from aqueous solution, the influence factors such as pH values, contact time, temperature and initial uranium concentration were optimized. Adsorption kinetics fitted well with the pseudo-second-order model, whereas adsorption isotherm matched well with the Langmuir isothermal adsorption model, with the maximum sorption capacity of 518.