Publications by authors named "Shucheng Zhuang"
With the development of the SARS-CoV-2 pandemic, there have been doubts about the necessity of vaccine boosters for healthy adults. However, due to the lack of relevant evidence, current research is unable to provide reliable medical advice for COVID-19 boost in healthy adults. We conducted a retrospective observational study to evaluate the effectiveness of different COVID-19 vaccination regimens by investigating the SARS-CoV-2 infection status of healthy donors in Southeast China.
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- The study evaluated the antibody response duration and effectiveness of inactivated COVID-19 vaccines among healthy blood donors, analyzing samples from 1,417 participants who received either 2 or 3 doses.
- Results showed that neutralizing antibodies peaked around one month post-vaccination but declined significantly over time, with notable drops in effectiveness against Omicron variants compared to earlier strains.
- The findings indicate that while a 3-dose regimen extends antibody duration, the ability of the antibodies to neutralize circulating Omicron variants is markedly reduced.