A sophisticated mechanism governs Pol ζ activity in response to replication stress.

DNA polymerase ζ (Pol ζ) plays an essential role in replicating damaged DNA templates but contributes to mutagenesis due to its low fidelity. Therefore, ensuring tight control of Pol ζ's activity is critical for continuous and accurate DNA replication, yet the specific mechanisms remain unclear. This study reveals a regulation mechanism of Pol ζ activity in human cells.

[Improving the facial skin and oral mucosa integrity of patients with oral endotracheal intubation].

The problems of damage to facial skin and oral mucus affecting intubated patients have seldom been effectively improved. The purpose of this project was to reduce the incidence of defects in facial skin and oral mucosa integrity in patients with oral endotracheal intubation. The main factors identified by data collection were: 1.