Publications by authors named "Shuchang Ye"
Genetic effect of metformin use on risk of cancers: evidence from Mendelian randomization analysis.
Diabetol Metab Syndr
December 2023
Article Synopsis
- Recent studies suggest that metformin, a diabetes medication, may have a positive impact on preventing and treating certain cancers, though more evidence is needed on its genetic effects.
- Researchers conducted a two-sample Mendelian Randomization analysis to explore the causal relationship between metformin use and 26 types of cancers, finding a significant protective effect specifically for HER-positive breast cancer.
- The study identified total testosterone levels as a significant mediator in the relationship between metformin use and HER-positive breast cancer, indicating that the drug may help reduce the risk of this cancer through hormonal pathways.