Publications by authors named "Shucai Xiao"

Article Synopsis
  • Hypertrophic cardiomyopathy (HCM) is a genetic heart condition causing thickening of the heart muscle, potentially leading to serious health issues like heart failure and sudden death, with unclear underlying causes and limited treatments.
  • The study utilized bioinformatics and lab experiments to identify important genes and pathways linked to HCM and to find new drug candidates for potential treatments.
  • Researchers found 145 upregulated and 149 downregulated genes related to HCM, identified a notable miRNA (miR-1469), and screened multiple non-toxic drugs that might influence these key genes, aiming to enhance treatment options for HCM.
View Article and Find Full Text PDF

Background: Triglyceride-glucose (TyG) index is linked to a poor prognosis for cardiovascular condition and is a valid indicator of insulin resistance. This study evaluated the potential predicting usefulness of the TyG index for all-cause mortality, both short- and long-term, for those concerning critical coronary artery disease (CAD).

Methods: In this study, information from 5452 critically-ill individuals with CAD in intensive care units were gathered from the Medical Information Marketplace in Intensive Care (MIMIC-IV) database.

View Article and Find Full Text PDF

The triglyceride glucose body mass index (TyG-BMI) is a potential indicator for insulin resistance, but its association with mortality in diabetic patients is unclear. This study investigates the relationship between TyG-BMI and all-cause and cardiovascular mortality in diabetics. The study included 3109 diabetic patients from the National Health and Nutrition Examination Survey (2001-2018).

View Article and Find Full Text PDF

Background: The association between the triglyceride-glucose (TyG) index and mortality in cardiovascular disease (CVD) patients with diabetes or pre-diabetes remains unclear. This study aimed to investigate the relationship between baseline TyG index and all-cause and cardiovascular (CV) mortality in CVD patients with diabetes or pre-diabetes among American adults. .

View Article and Find Full Text PDF

Background: To investigate the association between sleep duration and urgency urinary incontinence (UUI) among adult women.

Methods: Cross-sectional data were retrieved from the 2005-2014 National Health and Nutrition Examination Survey. To explore the association between sleep duration and urgency urinary incontinence, multivariable logistic regression and restricted cubic spline (RCS) regression analysis was carried out.

View Article and Find Full Text PDF

Objective: This study aimed to identify risk factors for coronary heart disease (CHD) in patients with type 2 diabetes mellitus (T2DM), build a clinical prediction model, and draw a nomogram.

Study Design And Methods: Coronary angiography was performed for 1,808 diabetic patients who were recruited at the department of cardiology in The Second Affiliated Hospital of Nanchang University from June 2020 to June 2022. After applying exclusion criteria, 560 patients were finally enrolled in this study and randomly divided into training cohorts ( = 392) and validation cohorts ( = 168).

View Article and Find Full Text PDF

Background: Compared with conventional medicines, angiotensin receptor-neprilysin inhibitor (ARNI) could further improve the prognosis for multiple cardiovascular diseases, such as heart failure, hypertension, and myocardial infarction. However, the relationship between ARNI therapy and the recurrence of atrial fibrillation (AF) after radiofrequency catheter ablation is currently unknown.

Methods: This study is a retrospective cohort study.

View Article and Find Full Text PDF

Background: This study aimed to establish and assess a prediction model for patients with persistent atrial fibrillation (AF) treated with nifekalant during the first radiofrequency catheter ablation (RFCA).

Methods: In this study, 244 patients with persistent AF from January 17, 2017 to December 14, 2017, formed the derivation cohort, and 205 patients with persistent AF from December 15, 2017 to October 28, 2018, constituted the validation cohort. The least absolute shrinkage and selection operator regression was used for variable screening and the multivariable Cox survival model for nomogram development.

View Article and Find Full Text PDF