A comparative analysis of amino acid encoding schemes for the prediction of flexible length linear B-cell epitopes.

Linear B-cell epitopes have a prominent role in the development of peptide-based vaccines and disease diagnosis. High variability in the length of these epitopes is a major reason for low accuracy in their prediction. Most of the B-cell epitope prediction methods considered fixed length of epitope sequences and achieved good accuracy.

A lightweight neural network with multiscale feature enhancement for liver CT segmentation.

Segmentation of abdominal Computed Tomography (CT) scan is essential for analyzing, diagnosing, and treating visceral organ diseases (e.g., hepatocellular carcinoma).

Functionalized carbon nanotubes as an alternative to traditional anti-HIV-1 protease inhibitors: An understanding towards Nano-medicine development through MD simulations.

The Human Immunodeficiency Virus (HIV) has been the source of epidemic infection of AIDS for a longer period. One of the most difficult tasks is identifying novel medications that can help to decrease or control this global health hazard by overcoming drug resistance. In recent decades' nanoparticles are emerging as extremely relevant in drug delivery platforms.

Visible Light Photoredox-Catalyzed Direct C-H Arylation of Quinoxalin-2(1)-ones with Diaryliodonium Salts.

A photoredox-catalyzed direct arylation of quinoxalin-2-(1)-ones using diaryliodonium triflates as the convenient, stable, and cheap aryl source is described. A broad variety of quinoxalin-2-(1)-ones are shown to react with structurally and electronically diverse diaryliodonium triflates, allowing efficient access to a wide variety of pharmaceutically important 3-arylquinoxalin-2-(1)-ones. The presented method is attractive with regard to operational simplicity, mild conditions, broad scope, scalability, and high functional group tolerance.

Unravelling genetic architecture and development of core set from elite rice lines using yield-related candidate gene markers.

Unlabelled: Assessing genetic diversity and development of a core set of elite breeding lines is a prerequisite for selective hybridization programes intended to improve the yield potential in rice. In the present study, the genetic diversity of newly developed elite lines derived from and crosses were estimated by 38 reported molecular markers. The markers used in the study consist of 24 gene-based and 14 random markers related to grain yield-related QTLs distributed across the rice genome.

A Novel Method for Improving VMAT Plan Quality and Deliverability.

Background: A new VMAT method called "Augmented Arc" (or simply Aug Arc) is proposed. The aim of this study is to demonstrate the validity of the proposed method in different clinical cases. Basically, Aug Arc refers to the portion(s) of the VMAT arc that is augmented with an additional arc to improve the plan quality.

Preoperative emobilisation of juvenile nasopharyngeal angiofibroma.

Introduction: Juvenile nasopharyngeal angiofibroma(JNA) are highly vascular benign tumours originating in the sphenopalatine fossa and may extend to the pterygopalatine fossa, paranasal sinuses, and nasal cavity. The management of JNA has evolved greatly with development of endoscopy. Treatment modality has changed from open approach to endoscopic approach due to various advantages offered by the endoscopic approach.

Bifunctional Dalteparin/Enoxaparin coated nanosilver formulation to prevent bloodstream infections during hemodialysis.

Catheter-related bloodstream infections (CRBSI) are the major concern of patients undergoing hemodialysis. The current study formulates bifunctional low molecular weight heparin (LMWH) coated nanosilver as an effective anticoagulant and antimicrobial/anti-biofilm agent. Nanosilver formulations were prepared using a microwave-assisted green synthesis approach and stabilized with pharmaceutically approved LMWH such as dalteparin (DL) and enoxaparin (EX) along with unfractionated heparin (HP) as a control.

A Unified Local-Global Feature Extraction Network for Human Gait Recognition Using Smartphone Sensors.

Smartphone-based gait recognition has been considered a unique and promising technique for biometric-based identification. It is integrated with multiple sensors to collect inertial data while a person walks. However, captured data may be affected by several covariate factors due to variations of gait sequences such as holding loads, wearing types, shoe types, etc.

Perceived usefulness of trauma audit filters in urban India: a mixed-methods multicentre Delphi study comparing filters from the WHO and low and middle-income countries.

Objective: To compare experts' perceived usefulness of audit filters from Ghana, Cameroon, WHO and those locally developed; generate context-appropriate audit filters for trauma care in selected hospitals in urban India; and explore characteristics of audit filters that correlate to perceived usefulness.

Design: A mixed-methods approach using a multicentre online Delphi technique.

Setting: Two large tertiary hospitals in urban India.

Awareness, attitude, and practice of materiovigilance among medical professionals at a tertiary care institute of national importance: A cross-sectional study.

Background: Medical faculty and residents have a key role in the reporting of adverse events associated with medical devices. However, at present, there are no published data regarding their knowledge, attitude, and practice about materiovigilance in India.

Materials And Methods: This was a cross-sectional questionnaire-based survey done among medical faculty and residents of a tertiary care institution of national importance.

MR imaging spectrum in COVID associated Rhino-Orbito-Cerebral mucormycosis with special emphasis on intracranial disease and impact on patient prognosis.

In the wake of the ongoing Coronavirus Disease 2019 (COVID-19) pandemic, a new epidemic of COVID associated mucormycosis (CAM) emerged in India. Early diagnosis and prompt treatment of this deadly disease are of paramount importance in improving patient survival. MRI is the cornerstone of diagnosis of early extrasinus disease, particularly intracranial complications which have traditionally been associated with a high mortality rate.

Prevalence of Positive Level IIb Lymph Nodes in Tongue Carcinoma: Experience From a Tertiary Care Center in North India.

Introduction Complications during and after dissection of level IIb lymph nodes include spinal accessory nerve (SAN) dysfunction, which results in the limitation of shoulder movements and, thus, hurts the quality of life. The current study aims to know the occurrence of level IIb lymph node positivity in tongue carcinoma. Methods This cross-sectional study was conducted from January 2019 to December 2019 in a tertiary care center in North India.

Tuberculous Skull Base Osteomyelitis With Cerebral Venous Sinus Thrombosis in an Immunocompetent Adolescent: A Case Report.

Skull-base osteomyelitis is a rare yet lethal entity. It is infrequently observed among immunocompetent children and young adults, and Mycobacterium is much less common among the various bacterial and fungal etiological causes noted. We report a rare case of a 17-year immunocompetent girl who presented with complaints of head and neck pain and restricted neck movements.

Performance of Bayesian and BLUP alphabets for genomic prediction: analysis, comparison and results.

We evaluated the performances of three BLUP and five Bayesian methods for genomic prediction by using nine actual and 54 simulated datasets. The genomic prediction accuracy was measured using Pearson's correlation coefficient between the genomic estimated breeding value (GEBV) and the observed phenotypic data using a fivefold cross-validation approach with 100 replications. The Bayesian alphabets performed better for the traits governed by a few genes/QTLs with relatively larger effects.

Wild type and gain of function mutant TP53 can regulate the sensitivity of pancreatic cancer cells to chemotherapeutic drugs, EGFR/Ras/Raf/MEK, and PI3K/mTORC1/GSK-3 pathway inhibitors, nutraceuticals and alter metabolic properties.

TP53 is a master regulator of many signaling and apoptotic pathways involved in: aging, cell cycle progression, gene regulation, growth, apoptosis, cellular senescence, DNA repair, drug resistance, malignant transformation, metastasis, and metabolism. Most pancreatic cancers are classified as pancreatic ductal adenocarcinomas (PDAC). The tumor suppressor gene is mutated frequently (50-75%) in PDAC.

Visual and hearing impairment and their association with depression among middle-aged and older individuals in India: Evidence from a cross-sectional study.

Objective: The aim of the study was to determine the prevalence and associated factors of visual and hearing impairment as well as to investigate their association with depression among individuals aged 45 and above in India.

Methods: The study utilized data from the Longitudinal Ageing Study in India (LASI) Wave 1, (2017-18). The total sample size of this study was 65,562 individuals aged 45 and above.

GWAS for main effects and epistatic interactions for grain morphology traits in wheat.

Unlabelled: In the present study in wheat, GWAS was conducted for identification of marker trait associations (MTAs) for the following six grain morphology traits: (1) grain cross-sectional area (GCSA), (2) grain perimeter (GP), (3) grain length (GL), (4) grain width (GWid), (5) grain length-width ratio (GLWR) and (6) grain form-density (GFD). The data were recorded on a subset of spring wheat reference set (SWRS) comprising 225 diverse genotypes, which were genotyped using 10,904 SNPs and phenotyped for two consecutive years (2017-2018, 2018-2019). GWAS was conducted using five different models including two single-locus models (CMLM, SUPER), one multi-locus model (FarmCPU), one multi-trait model (mvLMM) and a model for Q x Q epistatic interactions.

Sensitivity of liquid-based cytology in the diagnosis of mucormycosis in COVID-19 treated patients.

Background: The coronavirus disease 2019 (COVID-19) infection caused by the novel severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is associated with a wide range of disease patterns, ranging from mild to life-threatening pneumonia. COVID-19 can be associated with a suppressed immune response and/or hyperinflammatory state due to cytokine storm. Reduced immunity, combined with steroid usage to prevent cytokine storm along with various pre-existing co morbidities can prove to be a fertile ground for various secondary bacterial and fungal infection, including mucormycosis.

Extreme learning machine and bayesian optimization-driven intelligent framework for IoMT cyber-attack detection.

The Internet of Medical Things (IoMT) is a bionetwork of allied medical devices, sensors, wearable biosensor devices, etc. It is gradually reforming the healthcare industry by leveraging its capabilities to improve personalized healthcare services by enabling seamless communication of medical data. IoMT facilitates prompt emergency responses and provides improved quality of medical services with minimum cost.

Relationship between depressive symptoms and self-reported menstrual irregularities during adolescence: evidence from UDAYA, 2016.

Background: The study examined the prevalence of self-reported menstrual irregularities during adolescence and explored the association of depressive symptoms with self-reported menstrual irregularities in adolescents in two major states of Uttar Pradesh and Bihar in India.

Methods: This study is based on the data obtained from the first round of the "Understanding the lives of adolescents and young adults" (UDAYA, 2016) survey. The effective sample size for the study was 12,707 adolescent girls aged 10-19 years.

Intrapartum care algorithms for liquor abnormalities: oligohydramnios, meconium, blood and purulent discharge.

Aim: To construct evidence-based algorithms for the assessment and management of common amniotic fluid abnormalities detected during labour.

Population: Low-risk singleton, term pregnant women in labour.

Setting: Birth facilities in low- and middle-income countries.

Clinical algorithms for the management of intrapartum maternal urine abnormalities.

Aim: To develop evidence-based clinical algorithms for management of common intrapartum urinary abnormalities.

Population: Women with singleton, term pregnancies in active labour and immediate postnatal period, at low risk of complications.

Setting: Healthcare facilities in low- and middle-income countries.

Constructing evidence-based clinical intrapartum care algorithms for decision-support tools.

Aim: To describe standardised iterative methods used by a multidisciplinary group to develop evidence-based clinical intrapartum care algorithms for the management of uneventful and complicated labours.

Population: Singleton, term pregnancies considered to be at low risk of developing complications at admission to the birthing facility.

Setting: Health facilities in low- and middle-income countries.