Parameters Governing the Formation of Photopolymerized Silica Sol-Gel Monoliths in PDMS Microfluidic Chips.

Although polydimethylsiloxane (PDMS) microfluidic chips provide an alternative to more expensive microfabricated glass chips, formation of monolithic stationary phases in PDMS is not a trivial task. Photopolymerized silica sol-gel monoliths were fabricated in PDMS based microfluidic devices using 3-trimethoxysilylpropylmethacrylate (MPTMOS) and glycidyloxypropyltrimethoxysilane (GPTMOS). The monolith formation was optimized by identifying a suitable porogen, controlling monomer concentration, functional additives, salts, porogen, wall attachment methods, and rinsing procedures.