Photocatalytic Alkylation/Arylative Cyclization of -Acrylamides of -Heteroarenes and Arylamines with Dihydroquinazolinones from Unactivated Ketones.

We describe a visible-light photoredox-catalyzed alkylation/arylative cyclization of -acrylamides─from 2-arylindoles, 2-arylbenzimidazoles, or -substituted anilines─with ketone-derived dihydroquinazolinones, accessing indolo- and benzimidazolo[2,1-]isoquinolines or 2-oxindoles. The consecutive incorporation of alkyl- and aryl-carbogenic motifs across a C=C bond via formal cleavage of ketone α-C-C and arene C-H bonds leads to the formation of five- and six-membered rings, with an all-carbon quaternary stereocenter. This dicarbofunctionalization elaborates aromatization-driven radical C-C functionalization of unactivated aliphatic ketones to construct diverse cyclic structures with functionality tolerance.

Assessment of Kidney Involvement in COVID-19 Patient.

Background And Aim: Physicians need to be aware of the difficulties that SARS-CoV-2 infection brings to other regions of the body, such as the kidneys, even though the key emphasis is on pulmonary characteristics. The most frequent kidney complication among COVID-19 hospitalized patients is considered acute kidney injury (AKI). This study aimed to describe overall different aspects of acute kidney injury (AKI) in COVID-19 patients admitted to JLNMCH during the COVID-19 pandemic and to determine the prevalence of AKI among COVID-19 hospitalized patients.