Publications by authors named "Shubha Rani Sharma"
Article Synopsis
- Microbial interactions in ecosystems are heavily influenced by exopolysaccharides (EPSs), which are substances produced by microorganisms that play key roles in communication and cooperative behaviors.
- EPSs function as signaling molecules that facilitate chemical communication among microbes and enable them to assess population density through a process called quorum sensing (QS).
- This review highlights the importance of EPS in shaping microbial communities, affecting how they organize, stick together, and withstand environmental challenges, offering essential insights for future research in microbial ecology and its applications in various fields.
The study investigated production, characterisation, and biological properties of exopolysaccharide (EPS) from a thermophilic bacterium, using sucrose as a main carbon source at a temperature of 75 °C, resulting in a yield of 2.87 g/L. The surface topology of EPS was determined using FESEM indicating its porous nature.
View Article and Find Full Text PDFScoparone (6, 7 dimethylesculetin) is a biologically active compound derived from the herb having anti-inflammatory, anti-lipemic, and anti-allergic roles. Activation of the constitutive androstane receptor (CAR) in primary hepatocytes of both wild-type and humanized CAR mice by scoparone, accelerates bilirubin and cholesterol clearance . This can prevent gallstones which is a dreaded gastrointestinal disease.
View Article and Find Full Text PDFThermophiles are the microorganisms which thrive under extreme conditions such as high temperature, making them significant for scientific interest. This study provides information based on isolation of thermophilic strain from Surajkund and Ramkund, hot spring of Jharkhand at 50, 60 and 70 °C. Two of the best isolates were used for the extraction of exopolysaccharides.
View Article and Find Full Text PDFArticle Synopsis
- The study analyzed the structure and composition of gallstones from the Jharkhand region using various advanced techniques like FESEM and ICP-OES to understand their characteristics.
- The analysis revealed specific structures of cholesterol and pigment gallstones, identified heavy metals present, and confirmed the presence of compounds like cholesterol and calcium bilirubinate.
- The findings of this research can improve treatment methods for gallstones by providing insights into their compositions, potentially changing treatment practices for healthcare providers.
Article Synopsis
- Gallstones can lead to serious health issues, including gallbladder cancer, and their classification helps in understanding their causes and treatment options.
- Diagnosing gallstones can be aided by analyzing changes in serum parameters, which may provide early warning signs of stone formation.
- The review summarizes historical and recent classifications of gallstones, emphasizes the need for further research into the correlation between serum level changes and gallstone types, and highlights the potential for improved prevention and diagnosis methods.
Bio-fabrication of thermozyme-based nano-biosensors: their components and present scenario.
J Mater Sci Mater Electron
January 2022
An amalgamation of microbiology, biocatalysis, recombinant molecular biology, and nanotechnology is crucial for groundbreaking innovation in developing nano-biomedicines and sensoristics. Enzyme-based nano-biosensor finds prospective applications in various sectors (environmental, pharmaceutical, food, biorefineries). These applications demand reliable catalytic efficiency and functionality of the enzyme under an extreme operational environment for a prolonged period.
View Article and Find Full Text PDFIntroduction: infection is among the 17 most neglected tropical diseases identified by World Health Organization and to be eradicated by 2030. This parasite infects the central nervous system (Neurocysticercosis [NCC]) and intestine [Taeniasis]). NCC is the most frequent cause of acquired epilepsy in endemic regions and Taeniasis is responsible for the widespread malnutrition and abdominal discomfort among children.
View Article and Find Full Text PDFIn vitro analysis of gallstone formation in the presence of bacteria.
Indian J Gastroenterol
October 2020
Article Synopsis
- The study aimed to investigate the role of certain bacteria in gallstone formation, focusing on their biliary activities like urease and slime production under in vitro conditions with high cholesterol levels.
- The researchers used a bile-like media to test four different bacteria isolated from gallstones, finding that only Helicobacter did not produce slime, while all bacterial sets showed significantly less nucleation time compared to a bacteria-free control.
- Results indicated that bacterial slime production contributes to gallstone solidification, while other bacterial activities may worsen gallstone formation, highlighting their role in the disease's severity.
A total of 41 isolates were obtained from various samples (soil, mud, and water) of Surajkund hot spring, Jharkhand, at three different isolation temperatures of 50°C, 60°C, and 70°C. However, our interest was in the thermophilic strains that were isolated at 60°C and 70°C. Four isolates at 70°C (BITSNS038, BITSNS039, BITSNS040, BITSNS041) are the producers of thermozymes, namely amylase, xylanase, and cellulase, respectively.
View Article and Find Full Text PDFAnalysis of gallstone composition and structure in Jharkhand region.
Indian J Gastroenterol
January 2015
Article Synopsis
- The study aimed to analyze the structure and chemical composition of gallstones to improve treatment methods.
- A total of 459 gallstones were examined, categorized into pigmented, cholesterol, and mixed stones, using various analytical techniques to assess their properties.
- Results showed that pigmented gallstones were the most common, with unique structural characteristics and higher thermal stability compared to cholesterol gallstones, indicating a correlation between composition and gallstone morphology.