Publications by authors named "Shuba L"
Objective: To conduct a pilot study to evaluate and compare the 24-hour habitual intraocular pressure (IOP) and ocular perfusion pressure (OPP) fluctuation in glaucoma patients treated with medical therapy, selective laser trabeculoplasty (SLT) or trabeculectomy.
Design: Pilot study.
Participants: Criteria for inclusion were patients aged 18 years or older with well-controlled IOP with either maximum tolerated medical therapy, previous SLT, or previous trabeculectomy.
Article Synopsis
- The study aims to see if changes in macular perfusion density (PD) can be detected through OCTA imaging before the thinning of the ganglion cell layer (GCL) in patients with early glaucoma.
- Researchers compared OCT and OCTA imaging in 80 glaucoma patients and 42 healthy subjects every 4 months, assessing GCL thickness and macular PD in different areas of the retina.
- Results indicated that a decrease in GCL thickness often occurs before noticeable changes in macular PD, suggesting that tracking GCL thickness may be more effective in identifying early glaucoma progression.
Purpose: To determine whether more severe baseline damage impedes measurement of minimum rim width (MRW) and peripapillary retinal nerve fiber layer thickness (RNFLT) change in glaucoma patients because of a floor effect.
Design: Prospective, longitudinal cohort study in a hospital-based setting.
Participants: The study included patients with open-angle glaucoma and healthy control subjects.
Background/aims: Optical coherence tomography angiography (OCT-A) images are subject to variability, but the extent to which learning impacts OCT-A measurements is unknown. We determined whether there is a learning effect in glaucoma patients and healthy controls imaged with OCT-A.
Methods: Ninety-one open-angle glaucoma patients and 54 healthy controls were imaged every 4 months over a period of approximately 1 year in this longitudinal cohort study.
Purpose: Post-acute non-arteritic ischemic optic neuropathy (NAION) and glaucomatous optic neuropathy (GON) can be difficult to differentiate clinically. Our objective was to identify optical coherence tomography (OCT) parameters to help differentiate these optic neuropathies.
Methods: We compared 12 eyes of 8 patients with NAION and 12 eyes of 12 patients with GON, matched for age and visual field mean deviation (MD).
Objective: The aim: To conduct a comparative analysis of the health indicators of students who were engaged in various types of sports during physical education classes (using the example of power sports).
Patients And Methods: Materials and methods: The research was conducted in 2019-2021 when the male students (n=96) were studying at the 1st and 2nd years in Kharkiv State Academy of Physical Culture. We examined the health indicators of 17-19-year-old students, who were engaged in various power sports: powerlifting, kettlebell lifting, armsport and CrossFit.
Correlation between structural data from optical coherence tomography and functional data from the visual field may be suboptimal because of poor mapping of OCT measurement locations to VF stimuli. We tested the hypothesis that stronger structure-function correlations in the macula can be achieved with fundus-tracking perimetery, by precisely mapping OCT measurements to VF sensitivity at the same location. The conventional 64 superpixel (3° × 3°) OCT grid was mapped to VF sensitivities averaged in 40 corresponding VF units with standard automated perimetry (conventional mapped approach, CMA) in 38 glaucoma patients and 10 healthy subjects.
View Article and Find Full Text PDFImportance: Estimating the rate of glaucomatous visual field change provides practical assessment of disease progression and has implications for management decisions.
Objective: To assess the rates of visual field change in patients receiving treatment for glaucoma compared with healthy individuals over an extensive follow-up period and to quantify the impact of important covariates for these rates.
Design, Setting, And Participants: This prospective longitudinal cohort study was conducted in a hospital-based setting from January 1991 to February 2020.
Purpose: To determine the impact of glaucoma severity on rates of change of minimum rim width (MRW), peripapillary retinal nerve fiber layer (RNFL), and macular ganglion cell layer (GCL) thickness.
Design: Prospective, cohort study.
Methods: Glaucoma patients and healthy subjects had optical coherence tomography scans at 6-month intervals.
Purpose: No consensus exists on the relative superiority among criteria for evaluating glaucomatous visual field (VF) damage. We compared the sensitivities and specificities of 5 criteria-Glaucoma Hemifield Test (GHT), Hoddap-Anderson-Parrish 2 (HAP2), Foster, United Kingdom Glaucoma Treatment Study (UKGTS), and Low-pressure Glaucoma Treatment Study (LoGTS)-across various levels of functional and structural glaucomatous damage.
Design: Retrospective cross-sectional study.
Article Synopsis
- Exfoliation syndrome is a systemic disorder characterized by the buildup of abnormal protein aggregates in the eye, leading to increased risk of glaucoma and potential blindness.
- The study aimed to explore the association between exfoliation syndrome and rare genetic variants that could affect protein function, using whole-exome sequencing on participants from 14 countries over 20 years.
- Results showed that individuals with exfoliation syndrome were more likely to have harmful genetic variants in the CYP39A1 gene compared to those without the condition, indicating a potential genetic factor in the disorder.
Purpose: To determine whether the 10-2 test of the Humphrey Field Analyzer detected a higher proportion of abnormal visual fields compared with the 24-2 test in the central 10° of patients with early glaucomatous visual field damage.
Design: Prospective observational study.
Participants: Patients with open-angle glaucoma and healthy control participants.
Purpose: To identify characteristics of patients with early open-angle glaucoma exhibiting greater macular perfusion density (PD) loss compared with macular ganglion cell layer (GCL) thickness loss.
Design: Cross-sectional study.
Methods: Optical coherence tomography (OCT) imaging of the optic nerve head and macula was conducted in patients and healthy control subjects.
Background/aims: Quantitative analysis of optical coherence tomography angiography (OCT-A) images requires a reproducible approach that accounts for sectoral loss. The objective of this study was to determine whether an index that accounts for both global (perfusion density, PD) and asymmetric loss of perfusion, rather than PD alone, more reliably measures loss of perfusion in patients with glaucoma.
Methods: We analysed macular OCT-A scans of 95 glaucoma patients and 59 control subjects.
Background/aims: To determine the effect of glaucoma on outer retinal layer thickness in eyes with horizontal hemifield visual field (VF) defects.
Methods: We conducted a cross-sectional study in glaucomatous eyes with repeatable (in three or examinations) horizontal hemifield VF (programme 24-2) defect defined as: all five nasal VF locations immediately either above or below the horizontal midline abnormal in the pattern deviation plot with p<0.5%; no mirror-image adjacent 5 VF locations abnormal in the pattern deviation plot and no non-edge VF locations in the non-affected hemifield abnormal in the pattern deviation plot with p<1%.
Purpose: The effectiveness of selective laser trabeculoplasty (SLT) was compared with argon laser trabeculoplasty (ALT) in a randomized clinical trial for patients with medically uncontrolled open-angle glaucoma who have previously received 360° SLT.
Design: An active equivalence parallel armed randomized control trial.
Participants: Patients with open-angle glaucoma including pigmentary dispersion syndrome and pseudoexfoliation syndrome were enrolled into the study from 7 different sites across Canada.
Objective: Laser trabeculoplasty effectively reduces intraocular pressure (IOP) in primary open angle glaucoma, with argon laser trabeculoplasty (ALT) and selective laser trabeculoplasty (SLT) showing equivalent outcomes. However, it is unclear which laser modality is more effective in pseudoexfoliation (PXE) glaucoma. This study aims to compare the effectiveness of ALT and SLT in PXE glaucoma.
View Article and Find Full Text PDFPurpose: To determine whether: (1) change in lamina cribrosa depth occurs more frequently than change in neuroretinal parameters in glaucoma, and (2) Bruch's membrane or anterior sclera should be used as a reference plane when measuring laminar depth.
Design: Prospective observational study.
Participants: One hundred fifty-five glaucoma patients and 35 healthy controls.
Glaucoma is a medical term describing a group of progressive optic neuropathies characterized by degeneration of retinal ganglion cells and retinal nerve fibre layer and resulting in changes in the optic nerve head. Glaucoma is a leading cause of irreversible vision loss worldwide. With the aging population it is expected that the prevalence of glaucoma will continue to increase.
View Article and Find Full Text PDFBackground: Trabeculectomy is frequently performed in patients with glaucoma who are deteriorating, although its effects on rates of visual field (VF) progression are not fully understood. We studied the rate of VF progression post trabeculectomy comparing with medically treated patients matched for VF loss.
Methods: Medical records of patients who underwent trabeculectomy alone or combined with cataract extraction were reviewed.
Purpose: To determine whether structural abnormalities of the lamina cribrosa explain the presence of optic disc hemorrhages, we determined the spatial concordance between disc hemorrhages and laminar disinsertions from the sclera.
Design: Prospective noninterventional study.
Participants: From open-angle glaucoma patients followed up prospectively, we identified 52 eyes of 46 open-angle glaucoma patients with optic disc hemorrhage (ODH+ group) in at least 1 optic disc photograph during follow-up.