Publications by authors named "Shuao Lu"
Cell Mol Life Sci
January 2025
Article Synopsis
- HSV-1 infection can lead to lung injury, and a study found that lower levels of FcRn (a protein) are linked to more severe lung damage caused by the virus.
- The study revealed that HSV-1 increases the methylation of the FcRn gene, which reduces its expression by promoting DNMT3b, a protein that inhibits transcription through a specific region of the FcRn promoter.
- Inhibiting ferroptosis (a type of cell death) with a drug helped reduce lung injury in cases affected by HSV-1, indicating that targeting FcRn might be a promising therapeutic approach.
Free Radic Biol Med
November 2024
Article Synopsis
- - Psoriasis is a chronic skin condition linked to immune system dysfunction and oxidative stress, with the neonatal Fc receptor (FcRn) playing a potential role in its severity according to clinical analyses.
- - In a mouse model of psoriasis, researchers found lower levels of FcRn in affected skin, and the ferroptosis pathway was activated, suggesting that FcRn may influence this process through the STAT3/SLC7A11 signaling pathway.
- - Experiments indicated that depleting FcRn increased psoriatic lesions and ferroptosis, while inhibiting this process or activating FcRn improved symptoms, pointing to possible new treatments for psoriasis.
