Application of digital model of mixed reality dynamic tracking technique in oral and maxillofacial surgery: a basic research.

Objectives: This paper aims to explore the application value of mixed reality in oral and maxillofacial surgery and to conduct dynamic tracking using an model.

Methods: By collecting preoperative enhanced CT data of patients, rebuilding 3D digital model, combined with 3D printing technology, dynamic tracking of lesions was realized in the model, and the efficiency of different registration methods was compared.

Results: The 3D visualized head and neck model was obtained by combining multiple anatomical models, and dynamic tracking was completed .

CCL2 promotes lymphatic metastasis via activating RhoA and Rac1 pathway and predict prognosis to some extent in tongue cancer.

Background: Oral tongue cancer is an extremely malignant tumor with high rate of lymphatic metastasis. Little is known about its invasion and metastasis mechanisms so far.

Methods: To clarify the main role of CCL2 in tongue cancer progression, we performed Transwell migration assay to confirm the effects of different concentrations of CCL2 on the migration and invasion of tongue cancer cells.

CXCL1 promoted the migration and invasion abilities of oral cancer cells and might serve as a promising marker of prognosis in tongue cancer.

Background: Oral tongue squamous cell carcinoma tends to metastasize to cervical lymphatic nodes early which leads to a 50% drop of survival rate. CXCL1 could be secreted by LNMTca8113 cell induced lymphatic endothelial cells and promoted LNMTca8113 cell migration. The current study aimed to further explore the effect of CXCL1 on the proliferation and migration abilities of tongue cancer cells and the prognostic value of serum CXCL1 in oral tongue squamous cell carcinoma.

Coexistence of and increases biofilm virulence and periapical lesions in rats.

The present study utilized an dual-species biofilm model and an rat post-treatment endodontic disease (PTED) model to investigate whether co-infection of and would aggravate periapical lesions. The results showed that co-culturing yielded a thicker and denser biofilm more tolerant to detrimental stresses compared with the mono-species biofilm, such as a starvation-alkalinity environment, mechanical shear force and bactericidal chemicals. Consistently, co-inoculation of and significantly increased the extent of periapical lesions compared with mono-species infection.