Phase Dependence of Surface Charge Measurement on Epoxy Insulator in CFN/CO under AC Voltage.

The application of binary gas mixtures consisting of heptafluorobutyronitrile (CFN) and carbon dioxide (CO) in AC GIS is currently attracting much attention. Therefore, the evaluation of the gas-solid interface charge distribution characteristics of epoxy resin is indispensable. Additionally, the phase-dependency of the charging behavior remains not fully understood.

Sensitive visual detection of norfloxacin in water by smartphone assisted colorimetric method based on peroxidase-like active cobalt-doped FeO nanozyme.

Norfloxacin is widely used owing to its strong bactericidal effect on Gram-negative bacteria. However, the residual norfloxacin in the environment can be biomagnified via food chain and may damage the human liver and delay the bone development of minors. Present work described a reliable and sensitive smartphone colorimetric sensing system based on cobalt-doped FeO magnetic nanoparticles (Co-FeO MNPs) for the visual detection of norfloxacin.

Construction of nitrogen-doped carbon dots-based fluorescence probe for rapid, efficient and sensitive detection of chlortetracycline.

Antibiotics are widely used in clinical medicine due to their excellent antibacterial abilities. As typical emerging pollutants, their misuse can lead to excess antibiotics entering the environment, causing antimicrobial resistance and leading to serious health problems via food chain. Herein, a nano-fluorescent probe based on nitrogen-doped carbon dots (N-CDs) was constructed for the sensitive detection of chlortetracycline (CTC).

Construction of fluorescent sensor array with nitrogen-doped carbon dots for sensing Sudan Orange G and identification of various azo compounds.

In this study, nitrogen-doped carbon dots (N-CDs) were facilely fabricated by one-pot hydrothermal method with levulinic acid and triethanolamine. A fluorescent sensor array was established for identifying azo compounds including Sudan Orange G (SOG), p-diaminoazobenzene, p-aminoazobenzene, azobenzene and quantitative detection of SOG. Experimental results revealed that azo compounds could quench the fluorescent intensity of N-CDs.

Smartphone-assisted array discrimination of sulfur-containing compounds and colorimetric-fluorescence dual-mode sensor for detection of 1,4-benzenedithiol based on peroxidase-like nanozyme g-CN@Cu, N-CDs.

Present work reported a novel nanozyme g-CN@Cu, N-CDs with excellent peroxidase-like activity obtained by loading Cu and N co-doped carbon dots on g-CN (graphitic carbon nitride). g-CN@Cu, N-CDs can catalyze HO to generate hydroxyl radical •OH, which oxidizes o-phenylenediamine to 2,3-diaminophenazine, which emits orange fluorescence under ultraviolet light irradiation. The experimental results confirmed that 1,4-benzenedithiol (BDT) could inhibit the peroxidase-like activity of g-CN@Cu, N-CDs.

Advanced Multiparallel-Connected Piezoresistive Physical Sensors: Elevating Performance Reliability of Flexible Strain and Pressure Sensors.

A physical sensor with a sensing medium comprising multiparallel-connected (MPC) piezoresistive pathways in both the vertical and horizontal directions was developed to achieve improved sensing performance. The MPC sensing medium reduces the total resistance and offsets noise, offering enhanced signal stability and device reliability and providing a high-performance sensing platform. The signal change and gauge factor (GF) of the 3PW-5L strain sensor (comprising three lines and five layers of piezoresistive pathways horizontally and vertically, respectively) were, respectively, 5.

Analysis of the incidence and influencing factors of dental caries and periodontitis in children aged 5-12 in Jinhua, Zhejiang province.

This study aims to examine the prevalence of dental caries and periodontitis among children aged 5-12 years in Jinhua, Zhejiang province, and analyze the influencing factors of dental caries and periodontitis. A total of 280 children meeting the study criteria for a first-time oral examination were retrospectively analyzed and divided into caries (n = 190), no-caries (n = 90), periodontitis (n = 85) and non-periodontitis group (n = 195) groups based on the presence of caries or periodontitis. An analysis of general survey questionnaires and logistic regression of dental caries and periodontitis among children in different groups was conducted.

High enrichment and sensitive measurement of oxytetracycline in tea drinks by thermosensitive magnetic molecular imprinting based magnetic solid phase extraction coupled with boron doped carbon dots.

As a typical kind of new pollutants, there are still some challenges in the rapid detection of antibiotics. In this work, a sensitive fluorescent probe based on boron-doped carbon dots (B-CDs) in combination with thermo-responsive magnetic molecularly imprinted polymers (T-MMIPs) was constructed for the detection of oxytetracycline (OTC) in tea drinks. T-MMIPs were designed, fabricated and employed to enrich OTC at trace level from tea drinks, and B-CDs were utilized as the fluorescent probe to detect the concentration of OTC.

Strategy for establishing sensitive fluorescent sensor toward p-nitrophenol integrating magnetic molecularly imprinted materials and carbon dots.

In this work, a sensitive fluorescent sensor toward p-nitrophenol (4-NP) integrating magnetic molecularly imprinted materials and carbon dots (CDs) was proposed. Magnetic material and CDs derived from K [Fe(CN)] and glucose were simultaneously obtained through simple one-step hydrothermal process. Introducing of molecularly imprinted materials based magnetic solid phase extraction (MSPE) endowed the constructed fluorescent sensor with higher sensitivity and selectivity.

Bimetal-Organic Framework-Loaded PVA/Chitosan Composite Hydrogel with Interfacial Antibacterial and Adhesive Hemostatic Features for Wound Dressings.

Silver-containing wound dressings have shown attractive advantages in the treatment of wound infection due to their excellent antibacterial activity. However, the introduction of silver ions or AgNPs directly into the wound can cause deposition in the body as particles. Here, with the aim of designing low-silver wound dressings, a bimetallic-MOF antibacterial material called AgCu@MOF was developed using 3, 5-pyridine dicarboxylic acid as the ligand and Ag and Cu as metal ion sites.

Highly selective and sensitive determination of doxycycline integrating enrichment with thermosensitive magnetic molecular imprinting nanomaterial and carbon dots based fluorescence probe.

Doxycycline (DOX), a typical tetracycline antibiotic, is widely used because of its excellent antibacterial activity. To develop effective method for DOX has attracted much more attention. Herein, a new detection technology integrating magnetic solid phase extraction (MSPE) based on thermosensitive magnetic molecularly imprinted polymers (T-MMIPs) and fluorescence spectrometry based on carbon dots (CDs) was established.

β-Cyclodextrin functionalized magnetic polyamine-amine dendrimers for high enrichment and effective analysis of trace bisphenolic pollutants in beverages.

Bisphenols (BPs) are typical endocrine disruptors, which can cause great effects on environmental, organisms and human health. In this study, β-Cyclodextrin (β-CD) functionalized polyamidoamine dendrimers-modified FeO nanomaterials (MNPs@PAMAM (G3.0)@β-CD) were facilely synthesized.

Effectiveness and safety of nab-paclitaxel and platinum as first-line chemotherapy for ovarian cancer: a retrospective study.

Objective: To evaluate the effectiveness and safety of nab-paclitaxel plus platinum as first-line chemotherapy for ovarian cancer (OC).

Methods: Patients administered platinum combined with nab-paclitaxel as first-line chemotherapy for epithelial OC, fallopian tube cancer, or primary peritoneal cancer from July 2018 to December 2021 were retrospectively evaluated. The primary outcome was progression-free survival (PFS).

Passive sampling of diverse pesticides in water by hydrophilic-lipophilic balance sorbent-embedded cellulose acetate membrane: Kinetics, equilibrium partitioning and field application.

Pesticides are useful products for agriculture and human life, but they are often released into surface waters and are hazardous to aquatic ecosystems. Pesticides monitoring in surface waters is challenging due to the great variety, ultratrace levels and nonpoint source pollution of pesticides; however, continuous passive sampling may be conducive to solving these problems. This work evaluated the performance of a newly developed passive sampler (hydrophilic-lipophilic balance sorbent-embedded cellulose acetate membrane, HECAM) for six types of currently used/present pesticides.

Highly efficient and simultaneous magnetic solid phase extraction of heavy metal ions from water samples with l-Cysteine modified magnetic polyamidoamine dendrimers prior to high performance liquid chromatography.

Due to the strong metal-sulfur interaction between mercapto groups and metal ions, which can be used to functionalize polyamidoamine dendrimer decorated FeO nanoparticles for high enrichment of trace heavy metal ions from waters. Based on this concept, polyamidoamine dendrimer modified FeO nanomaterials were functionalized with l-Cysteine and a new magnetic solid phase extraction for rapid adsorption and separation of Hg, Pb, Co and Cd from waters was established. The factors affecting extraction efficiency have been optimized.

Effective and selective measurement of 2,4-dinitroaniline utilizing constructed fluorescent carbon dots sensor derived from vitamin B.

2,4-Dinitroaniline is a multifunctional product and has been applicated in various fields. It has absorbed much concerns due to its large consumption and occurrence in many environmental matrices. It is urgent to explore reliable and sensitive measurement technology.

The synthetic lethality of targeting cell cycle checkpoints and PARPs in cancer treatment.

Continuous cell division is a hallmark of cancer, and the underlying mechanism is tumor genomics instability. Cell cycle checkpoints are critical for enabling an orderly cell cycle and maintaining genome stability during cell division. Based on their distinct functions in cell cycle control, cell cycle checkpoints are classified into two groups: DNA damage checkpoints and DNA replication stress checkpoints.

Myeloid-derived Suppressor Cells Activate Liver Natural Killer Cells in a Murine Model in Uveal Melanoma.

Objective: Elevated myeloid-derived suppressor cells (MDSCs) in many malignancies are associated with the increased risk for metastases and poor prognosis. Therefore, a mouse model of intraocular melanoma was established to explore how MDSCs influence liver metastases.

Methods: In this study, murine B16LS melanoma cells were transplanted into the posterior compartment (PC) of the eye of C57BL/6 mice.

Carbon dots fabricated by solid-phase carbonization using p-toluidine and l-cysteine for sensitive detection of copper.

In this study, a label-free "turn off" fluorescent sensor has been resoundingly fabricated using carbon dots (CDs) for ultrasensitive detection of copper ions (Cu). CDs are prepared by solid phase carbonization method using p-toluidine and l-cysteine as the precursors. The synthesized CDs exhibited the highest fluorescence intensity with excitation and emission wavelengths set at 300 nm and 400 nm, respectively.

Magnetic solid phase extraction and determination of polychlorinated biphenyls in beverages utilizing C modified magnetic polyamido-amine dendrimers in combination with gas chromatography-tandem mass spectrometry.

Polychlorinated biphenyls (PCBs) are persistent organic pollutants which are widely present in environment and harmful to human health. In this study, an efficient and convenient magnetic solid phase extraction method with C modified magnetic polyamido-amine (PAMAM) dendrimers as sorbents was established for enriching trace amounts of PCBs in beverage samples. Gas chromatography-tandem mass spectrometry (GC-MS/MS) was utilized for analysis of PCBs.

Detection of novel variant and functional study in a Chinese family with nonsyndromic oligodontia.

Objectives: To investigate the pathogenic gene of a patient with nonsyndromic oligodontia, and analyze its possible pathogenic mechanism.

Subjects And Methods: The variant was detected by whole exome sequencing (WES) and Sanger sequencing in a family with oligodontia. Bioinformatic and structural analyses were used to analyze variant.

Novel electrochemical sensor from magnetic carbon dots and cetyltrimethylammonium bromide for sensitive measurement of tetrabromobisphenol A in beverages.

Present work depicted a novel electrochemical sensor fabricated with magnetic carbon dots (M-CDs) and cetyltrimethylammonium bromide (CTAB) modified glassy carbon electrode (GCE) for selective measurement of 3,3',5,5'-tetrabromobisphenol A (TBBPA) in beverages. The M-CDs composite material revealed good electrocatalytic activity, and CTAB has strong hydrophobic interaction which enable it have good enrichment capacity of hydrophobic compounds, and combination of them further enhances the electrochemical signal. Hence CTAB decoration can markedly improve the detection performance of TBBPA.

Sensitive determination of polychlorinated biphenyls from beverages based on switchable solvent microextraction: A robust methodology.

Polychlorinated biphenyls (PCBs) are a kind of hazardous persistent organic contaminants and widely present in nature due to large consumption in the past. Although PCBs have been banned in many countries of the world, they are still present at trace level in food and water samples. It is of significant value to establish reliable enrichment and detection method.