A multidimensional luminescent sensor for specific and in situ visual detection of dopamine.

Dopamine (DA) is a neurotransmitter with biologically important properties that play an important role in the function of the central nervous and cardiovascular systems. Abnormal DA concentrations in human biological fluids are thought to be associated with many neurological disorders. Luminescence have now become an effective method for the detection of DA.

Inhibiting miRNA-146a suppresses mouse gallstone formation by regulating LXR/megalin/cubilin-media cholesterol absorption.

Background: miRNA has been implicated in regulating cholesterol homeostasis, a critical factor in gallstone formation. Here, we focused on elucidating the role of miR-146a in this pathological process.

Methods: C57BL/6 mice were fed with lithogenic diet (LD) and injected with miR-146 antagomir (anta-146) via the tail vein for various weeks.

U-shaped association between serum 25-hydroxyvitamin D concentrations and urinary leakage among adult females aged 45 years and over in the United States: a cross-sectional study.

Background: The relationship between serum vitamin D status and urinary leakage (UL) among middle-aged females needs to be further studied. The aim of this study was to evaluate the association of serum 25-hydroxyvitamin D [25(OH)D] concentrations with UL among American females ages 45 years and over.

Methods: Seven cycles of the National Health and Nutrition Examination Survey (NHANES) with self-report UL data, were used.

Highly sensitive sensing of DPA by lanthanide metal-organic frameworks and detection of fiber membranes.

The detection of 2,6-pyridinecarboxylic acid (DPA), as a biomarker of Bacillus anthracis, has attracted wide attention. In previous reports of DPA detection, fluorescent probes may not have high specificity. Therefore, the rational design and development of fluorescent sensors with excellent performance is of great significance for the detection of DPA.

Portable and Recyclable Luminescent Lanthanide Coordination Polymer Film Sensors for Adenosine Triphosphate in Urine.

Adenosine triphosphate (ATP) is a small molecule that is released to the urine from bladder urothelial cells and the bladder mucosal band of the human body. In certain cases, ATP can serve as a biomarker in bladder disease. For the practical applicability of luminescent sensors for ATP in urine, it is significant to find a new strategy for making the detection progress simple and available for in-field urine analysis.

Nanoarchitectonics of Indocyanine Green/Doxorubicin-Loaded Hydroxyl Boron Nitride Nanosheets for Chemophotothermal Therapy.

Biocompatible hydroxylated boron nitride nanosheets were effectively loaded with indocyanine green and doxorubicin using successive assembly. The indocyanine green/doxorubicin-loaded hydroxyl boron nitride nanosheets (ICG/DOX@OH-BNNS) integrated photothermal therapy and chemotherapy into a single nano vehicle. It had been confirmed that ICG/DOX@OH-BNNS could produce reactive oxygen species and exhibit excellent photothermal effects and light-triggered faster DOX release with NIR laser irradiation.

Two novel zinc-based MOFs as luminescence sensors to detect phenylglyoxylic acid.

Automobile exhaust gases, plastic pollutants, smoking, and other harmful substances can cause serious harm to human beings and the environment. Styrene, as a common airborne toxin, enters the human body through breathing or the skin and is discharged in the form of phenylglyoxylic acid (PGA). Therefore, specific, sensitive and trace detection of PGA is particularly important.

Three novel metal-organic frameworks with different coordination modes for trace detection of anthrax biomarkers.

Dipicolinic acid (DPA) is an anthrax biomarker. Its serious consequences make its detection a great need. In this paper, three novel metal-organic frameworks (MOFs) with different coordination modes were synthesized by a simple solvothermal method, which can be used as highly efficient fluorescence sensors for the highly selective and sensitive trace detection of DPA.

Fast Detection of Entacapone by a Lanthanide-Organic Framework with Rhombic Channels.

Entacapone (ENT) is a powerful catechol-O-methyl transferase inhibitor that is used for the diagnosis and treatment of Parkinson's syndrome, but the amount used must be well controlled to avoid overtreatment and side effect. Fast and selective detection of ENT needs well-matched energy levels and well-designed sensor-ENT interaction which is highly challenging. In this work, a water stable europium-based metal-organic framework (Eu-TDA) was synthesized to detect ENT by luminescence with excellent reusability and selectivity in the presence of main coexisting and interference species of plasma with a limit of detection of 5.

Two new lanthanide complexes with 5-(Pyrazol-1-yl)nicotinic acid: Structures and their anti-cancer properties.

Two new lanthanide complexes [PrL(EA)]NO (complex 1) and [SmL(EA)]NO (complex 2) (HL = 5-(Pyrazol-1-yl)nicotinic acid, EA = CHCHOH) were synthesized. The structures were characterized by single crystal X-ray and elemental analysis. The interaction between the complex and fish sperm DNA(FS-DNA) was monitored using ultraviolet and fluorescence spectroscopy, and the binding constants were determined.

Highly Emissive Metal-Organic Frameworks for Sensitive and Selective Detection of Nitrofuran and Quinolone Antibiotics.

The overuse of antibiotics makes its detection very significant for human health. New facile methods and high-performance sensory materials will be urgently needed for detection of antibiotics. Unfortunately, there are few reports on fluorescence enhancement of antibiotics detection.

Clinical performance of cantilevered resin-bonded fixed partial dentures for single tooth replacement in elderly patients.

Objective: To evaluate the clinical performance of cantilevered resin-bonded fixed partial dentures (CRBFPDs) in single tooth replacement in elderly patients at Qingdao Stomatological Hospital.

Methods: In total, 186 CRBFPDs in 153 patients were made from cobalt-chrome alloy. Panavia F 2.

Respiratory syncytial virus infection-induced mucus secretion by down-regulation of miR-34b/c-5p expression in airway epithelial cells.

Severe RSV infection is the main cause of hospitalization to children under the age of five. The regulation of miRNAs on the severity of RSV infection is unclear. The aim of the study was to identify the critical differential expression miRNAs (DE miRNAs) that can regulate the pathological response in RSV-infected airway epithelial cells.

DNA methylation down-regulates integrin β4 expression in asthmatic airway epithelial cells.

Background: Integrin β4 (ITGB4) is a hemi-desmosome protein which is downregulated in the airway epithelial cells of asthma patients. The proximal promoters and exons of ITGB4 contain CpG islands or multiple CpG sites both in human and mice, which indicated the possible methylation regulation of ITGB4 in airway epithelial cells.

Objective: We sought to unveil that DNA methylation regulates the decreased ITGB4 during the pathogenesis of asthma.

Airway epithelial integrin β4 suppresses allergic inflammation by decreasing CCL17 production.

Airway epithelial cells (AECs) play a key role in asthma susceptibility and severity. Integrin β4 (ITGB4) is a structural adhesion molecule that is down-regulated in the airway epithelium of asthma patients. Although a few studies hint toward the role of ITGB4 in asthmatic inflammation pathogenesis, their specific resultant effects remain unexplored.

Three coordination polymers with regulated coordination interactions as fluorescent sensors for monitoring purine metabolite uric acid.

A facile optical sensor for uric acid (UA), an early pathological signature for the metabolic function of humans, was developed based on water-stable coordination polymers (CPs). Herein, three new isostructural fluorescent CPs, [Ln(TCPB)(DMF)3]n (Ln = La, CP 1; Ce, CP 2 and Pr, CP 3; H3TCPB = 1,3,5-tris(1-(2-carboxyphenyl)-1H-pyrazol-3-yl)benzene), with various metal ions were solvothermally synthesized. Significantly, by regulating the metal-organic coordination interactions, the fabricated CP 3 can quantitatively recognize UA with higher sensitivity compared with CP 1 and CP 2.

Airway epithelial ITGB4 deficiency in early life mediates pulmonary spontaneous inflammation and enhanced allergic immune response.

Lung immune responses to respiratory pathogens and allergens are initiated in early life which will further influence the later onset of asthma. The airway epithelia form the first mechanical physical barrier to allergic stimuli and environmental pollutants, which is also the key regulator in the initiation and development of lung immune response. However, the epithelial regulation mechanisms of early-life lung immune responses are far from clear.

A Water-Stable Lanthanide Coordination Polymer as Multicenter Platform for Ratiometric Luminescent Sensing Antibiotics.

As a hot topic of global concern, the distinguishing and detecting of antibiotic pollution is crucial owing to its adverse effect on ecosystems and human health stemming from excessive use and poor management. Herein, a water-stable lanthanide coordination polymer sensor (Dy-TCPB) with multiple emitting centers is prepared. The versatile Dy-TCPB can conveniently differentiate various antibiotics, and displays a self-calibration luminescent response to nitrofurazone (NFZ) and furazolidone (FZD).

Variable DNA methylation of aging-related genes is associated with male COPD.

Background: Chronic obstructive pulmonary disease (COPD) is a chronic lung inflammatory disease which has a close relationship with aging. Genome-wide analysis reveals that DNA methylation markers vary obviously with age. DNA methylation variations in peripheral blood have the potential to be biomarkers for COPD.

Metal Nitrate Catalysis for Selective Oxidation of 5-Hydroxymethylfurfural into 2,5-Diformylfuran under Oxygen Atmosphere.

Selective synthesis of various versatile compounds from biomass is of great importance to displace traditional fossil fuel resources. Here, homogeneous metal nitrate (M(NO) )/(2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO) and M(NO) /TEMPO/NaNO catalyst systems in glacial acetic acid and acetonitrile, respectively, have been found to be highly active and practically sustainable for selective oxidation of 5-hydroxymethylfurfural (HMF) into 2,5-diformylfuran (DFF) using pure O or even O in air as the oxidant. The catalytic methods enable full HMF conversion with a nearly 100% DFF selectivity at 50 °C under atmospheric pressure using a very simple reaction setup and workup.

Efficacy of probiotic supplementary therapy for asthma, allergic rhinitis, and wheeze: a meta-analysis of randomized controlled trials.

Probiotic supplementary therapy to prevent allergic diseases, including asthma in children, has been widely explored in many randomized controlled trials. However, there is conflicting evidence on the effect of probiotic supplementation during pregnancy and infancy to the incidence of asthma and allergic rhinitis. This study was designed to systematically explore the potential effects of probiotic supplementation on the occurrence and development of asthma, wheeze, and allergic rhinitis.

Multicenter Metal-Organic Framework-Based Ratiometric Fluorescent Sensors.

Metal-organic frameworks (MOFs) with multiple emission centers are newly emerging as ratiometric sensors owing to their high sensitivity and high selectivity toward a wide range of targeted functional species. Energy transfer between the light-absorbing group and emission centers and between different emission centers is the key to rationally design and synthesize MOF-based ratiometric sensors. A good match between the energy levels of the light-absorbing groups and emission centers is the prerequisite for MOF-based sensors to exhibit multiple emissions, and a good match of the MOF-based sensors and those of the targeted species can increase the sensitivity and selectivity, but this match is highly challenging to obtain via synthesis.

ITGB4 deficiency induces senescence of airway epithelial cells through p53 activation.

Aging is characterized by a progressive loss of physiological integrity, leading to impaired organ function and, ultimately, increased vulnerability to death. Many complex diseases are related to aging, including asthma. In the lung, the airway epithelium serves as the first barrier to prevent the access of inspired external stimuli and dictates the initial stress responses.

ITGB4 deficiency in bronchial epithelial cells directs airway inflammation and bipolar disorder-related behavior.

Background: Chronic persistent airway inflammation has been associated with the comorbidity of asthma and bipolar disorder (BD). However, the direct relevance between airway inflammation and BD-like psychiatric comorbidity is almost unknown. Integrin β4 (ITGB4) is downregulated on the airway epithelial of asthma patients, which might play a critical role in the parthenogenesis of airway inflammation.

Three new species of Calocybe (Agaricales, Basidiomycota) from northeastern China are supported by morphological and molecular data.

Three new species, Calocybe aurantiaca, C. convexa, and C. decolorata, are described based on collections made in Shenyang City, Liaoning Province, China.