Publications by authors named "Shuangyan Wan"
Article Synopsis
- HCN channels are essential for controlling how neurons behave, and inhibiting HCN1 could help in treating neurological issues, but the details of how this inhibition happens weren't clear.
- Researchers used cryo-electron microscopy to show how the drug ivabradine binds to a specific site on the human HCN1 channel, revealing new structural details of this interaction.
- Additionally, they identified two existing FDA-approved drugs that can also target this binding site, paving the way for new treatments aimed at regulating HCN1 activity in neurological disorders.
Mesenchymal stem cells (MSCs) exert beneficial effects on the repair of bone tissue via both immunomodulatory functions and osteogenic differentiation. As one of the first miRNAs identified that regulate innate immune responses, miR-146a has been reported to serve as a negative-feedback regulator in several chronic inflammatory diseases. However, the majority of studies focus on understanding how miRNA-146a regulates immune cells and the associated immune-based disorders.
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