Protein tyrosine phosphatase PTPRO represses lung adenocarcinoma progression by inducing mitochondria-dependent apoptosis and restraining tumor metastasis.

Emerging evidence indicates that protein activities regulated by receptor protein tyrosine phosphatases (RPTPs) are crucial for a variety of cellular processes, such as proliferation, apoptosis, and immunological response. Protein tyrosine phosphatase receptor type O (PTPRO), an RPTP, has been revealed as a putative suppressor in the development of particular tumors. However, the function and the underlying mechanisms of PTPRO in regulating of lung adenocarcinoma (LUAD) are not well understood.

Efficacy of a modified twin block appliance compared with the traditional twin block appliance in children with hyperdivergent mandibular retrognathia: protocol for a single-centre, single-blind, randomised controlled trial.

Introduction: Compensatory mouth breathing, caused by nasopharyngeal obstructive diseases, is the main cause of hyperdivergent mandibular retrognathia in children. Such deformities require effective growth guidance before pubertal growth peaks. The traditional mandibular advancement device, twin block (TB), can guide the forward development of the mandible.

Four-Objective Optimizations of a Single Resonance Energy Selective Electron Refrigerator.

According to the established model of a single resonance energy selective electron refrigerator with heat leakage in the previous literature, this paper performs multi-objective optimization with finite-time thermodynamic theory and NSGA-II algorithm. Cooling load (R¯), coefficient of performance (ε), ecological function (ECO¯), and figure of merit (χ¯) of the ESER are taken as objective functions. Energy boundary (E'/kB) and resonance width (ΔE/kB) are regarded as optimization variables and their optimal intervals are obtained.

Maximum Efficient Power Performance Analysis and Multi-Objective Optimization of Two-Stage Thermoelectric Generators.

Two-stage thermoelectric generators have been widely used in the aerospace, military, industrial and daily life fields. Based on the established two-stage thermoelectric generator model, this paper further studies its performance. Applying the theory of finite-time thermodynamics, the efficient power expression of the two-stage thermoelectric generator is deduced firstly.

Multi-Objective Constructal Design for Quadrilateral Heat Generation Body with Vein-Shaped High Thermal Conductivity Channel.

Based on the quadrilateral heat generation body (HGB) proposed by previous literature, the multi-objective constructal design is performed. Firstly, the constructal design is performed by minimizing the complex function composed of the maximum temperature difference (MTD) and entropy generation rate (EGR), and the influence of the weighting coefficient (a0) on the optimal constructal is studied. Secondly, the multi-objective optimization (MOO) with the MTD and EGR as optimization objectives is performed, and the Pareto frontier with an optimal set is obtained by using NSGA-II.

Clinicopathological characteristics and cancer-specific prognosis of primary pulmonary lymphoepithelioma-like carcinoma: a population study of the US SEER database and a Chinese hospital.

Introduction: Primary pulmonary lymphoepithelioma-like carcinoma (PPLELC) is a rare histological type of non-small cell lung cancer (NSCLC), which accounts for less than 1% of NSCLC. Currently, there is no well-recognized treatment guideline for PPLELC.

Methods: We identified PPLELC patients from the Surveillance, Epidemiology, and End Results (SEER) dataset between 2000 and 2015 (n = 72) as well as from our medical center between 2014 and 2020 (n = 16).

[Characteristics and Source Apportionment of Black Carbon Over the Eastern Tibetan Plateau].

As the most important absorbing aerosol, black carbon (BC) can affect radiation, clouds, and surface snow cover over the Tibetan Plateau. In this study, the BC mass concentrations were measured using a seven-channel aethalometer (AE-33) in Litang County over the eastern Tibetan Plateau from July 5 to September 5, 2017. The aethalometer model, potential source contribution function (PSCF), and concentration-weighted trajectory (CWT) models were used to analyze the variation characteristics, potential sources, and affecting areas of BC.

[Vertical Distribution Characteristics of Boundary Layer Volatile Organic Compounds in Autumn in the Mixed Industrial and Rural Areas over the Northern Suburb of Nanjing].

Based on the sounding data of VOCs in the lower troposphere (0-1000 m) in the northern suburb of Nanjing in the autumn of 2020, the vertical profile distribution, diurnal variation, and photochemical reactivity of VOCs in this area were analyzed. The results showed that the volume fraction of VOCs decreased with the increase in height (72.1×10±28.

Efficient Power Characteristic Analysis and Multi-Objective Optimization for an Irreversible Simple Closed Gas Turbine Cycle.

On the basis of the established irreversible simple closed gas turbine cycle model, this paper optimizes cycle performance further by applying the theory of finite-time thermodynamics. Dimensionless efficient power expression of the cycle is derived. Effects of internal irreversibility (turbine and compressor efficiencies) and heat reservoir temperature ratio on dimensionless efficient power are analyzed.

The interaction between black carbon and planetary boundary layer in the Yangtze River Delta from 2015 to 2020: Why O didn't decline so significantly as PM.

Since the Air Pollution Prevention and Control Action Plan (air clean plan) issued in 2013, air quality has been in continuous improvement. The second stage of air clean plan since 2018 was focused on O controlling, but it still didn't decline so significantly as PM. This study conducted a long-term observation on black carbon (BC) and utilized the observational data of other air pollutants (PM, PM, NO, SO, CO and O), the meteorological elements and the vertical sounding data of PBL in Nanjing.

Four-Objective Optimization for an Irreversible Porous Medium Cycle with Linear Variation in Working Fluid's Specific Heat.

Considering that the specific heat of the working fluid varies linearly with its temperature, this paper applies finite time thermodynamic theory and NSGA-II to conduct thermodynamic analysis and multi-objective optimization for irreversible porous medium cycle. The effects of working fluid's variable-specific heat characteristics, heat transfer, friction and internal irreversibility losses on cycle power density and ecological function characteristics are analyzed. The relationship between power density and ecological function versus compression ratio or thermal efficiency are obtained.

Genome-wide CRISPR knockout screening identified G protein pathway suppressor 2 as a novel tumor suppressor for uveal melanoma metastasis.

Purpose: Uveal melanoma (UM) is the most common intraocular malignant tumor in adults. Due to the lack of effective treatments for metastatic UM, the survival of UM has not changed over the past 3 decades. Therefore, it is important to identify essential genes regulating the metastasis of UM.

RhoA with Associated TRAb or FT3 in the Diagnosis and Prediction of Graves' Ophthalmopathy.

During Graves' disease (GD) treatment, Graves' ophthalmopathy (GO) is often ignored because only mild ocular symptoms are present in early GD. Therefore, we performed isobaric tags for relative and absolute quantification (iTRAQ) analysis and measured relevant endocrine hormones to identify predisposing factors of GO. Serum samples from 3 patients with mild GD and GO and 3 patients with GD but without GO were analyzed by iTRAQ.

Nonradiative Energy Transfer from CsPbBr Nanocrystals to CdSe/CdS Nanocrystals for Efficient Light Down Conversion.

Semiconductor nanocrystals (NCs) are emerging luminescent materials with superior optical properties. However, the light-conversion application of NCs is restricted by reabsorption-induced fluorescent quenching. Here, a NC-NC Förster resonance energy transfer (FRET) system is developed by employing large CsPbBr NCs as donors and CdSe/CdS NCs as acceptors.

Performance Optimizations with Single-, Bi-, Tri-, and Quadru-Objective for Irreversible Diesel Cycle.

Applying finite time thermodynamics theory and the non-dominated sorting genetic algorithm-II (NSGA-II), thermodynamic analysis and multi-objective optimization of an irreversible Diesel cycle are performed. Through numerical calculations, the impact of the cycle temperature ratio on the power density of the cycle is analyzed. The characteristic relationships among the cycle power density versus the compression ratio and thermal efficiency are obtained with three different loss issues.

Solvent- and initiator-free fabrication of efficient and stable perovskite-polystyrene surface-patterned thin films for LED backlights.

We report a one-pot route for the synthesis of CsPbBr perovskite nanocrystals (PNCs) in styrene to form a glue-like polystyrene (PS) pre-polymer incorporating mono-dispersed PNCs. The pre-polymer enables solvent- and initiator-free fabricating and patterning PNC-PS light down-conversion films for liquid crystal display application. The mechanistic study reveals that the styrene molecules adsorbed on the PNC surface undergo self-initiated polymerization in the pre-polymerization process, forming stable surface capsulation over the PNCs.

Unexpected aliovalent cation substitution between two NLO materials LiBaBi(SeO)F and BaBi(SeO)FO.

One new combination, alkali-metal and alkaline earth-metal selenite fluoride, LiBaBi(SeO)F (LBBSF) and its analogue BaBi(SeO)FO (BBSF) were reported here for the first time. Unusual aliovalent cation substitution between them affected the layer thickness and made the bond strains of [SeO] enhanced, thereby inducing greater distortions and affecting the SHG efficiencies. This work may provide thoughts for exploring new NLO materials.

Estimation of radiative forcing and heating rate based on vertical observation of black carbon in Nanjing, China.

Owing to a lack of vertical observations, the impacts of black carbon (BC) on radiative forcing (RF) have typically been analyzed using ground observations and assumed profiles. In this study, a UAV platform was used to measure high-resolution in-situ vertical profiles of BC, fine particles (PM), and relevant meteorological parameters in the boundary layer (BL). Further, a series of calculations using actual vertical profiles of BC were conducted to determine its impact on RF and heating rate (HR).

Four-Objective Optimization of Irreversible Atkinson Cycle Based on NSGA-II.

Variation trends of dimensionless power density (PD) with a compression ratio and thermal efficiency (TE) are discussed according to the irreversible Atkinson cycle (AC) model established in previous literature. Then, for the fixed cycle temperature ratio, the maximum specific volume ratios, the maximum pressure ratios, and the TEs corresponding to the maximum power output (PO) and the maximum PD are compared. Finally, multi-objective optimization (MOO) of cycle performance with dimensionless PO, TE, dimensionless PD, and dimensionless ecological function (EF) as the optimization objectives and compression ratio as the optimization variable are performed by applying the non-dominated sorting genetic algorithm-II (NSGA-II).

Stable and transport indices applied to winter air pollution over the Yangtze River Delta, China.

Previous studies have developed a stable weather index (SWI) based on meteorological elements that adequately represent PM pollution over the North China Plain (NCP). However, the SWI performs poorly over the Yangtze River Delta (YRD) region because air pollution over this region is affected not only by stagnant weather (STAG) but also by transport (TRANS). For example, air pollutants can be transported from the NCP to the YRD by cold fronts.

Annual variations of black carbon over the Yangtze River Delta from 2015 to 2018.

In this study, the black carbon (BC) measurements in the atmosphere of Nanjing, China were continuously conducted from 2015 to 2018 using a Model AE-33 aethalometer. By combining dataset of PM, PM, CO, NO, SO, O and meteorological parameters, the temporal variations and the source apportionment of BC were given in this study. The results showed that the PM mass concentrations decreased in Nanjing, with an average annual rate of variation of 6.

[Temporal Evolution and Main Influencing Factors of Black Carbon Aerosol in Nanjing].

Temporal evolution of black carbon (BC) in Nanjing was studied along with its main influencing factors. The multi-wavelength aethalometer (AE-33) was used to select the typical month of each season to observe BC mass concentration, combined with atmospheric pollutant data, meteorological elements, and boundary layer detection data. Seasonal, daily, weekly trends, and source characteristics of BC were analyzed.

Rapid synthesis of quantum-confined CsPbBr perovskite nanowires using a microfluidic reactor.

Microfluidics has been considered as an effective platform in the mechanism study and large-scale manufacturing of nanomaterials. In this work, we report the facile synthesis of quantum-confined CsPbBr nanowires (NWs) by using a continuous-flow microfluidic reactor. The optimized reaction temperature is around 50 °C, and one "synthesis run" by microfluidics requires only ten minutes.

Controlled Growth of CH NH PbBr Perovskite Nanocrystals via a Water-Oil Interfacial Synthesis Method.

Fundamental insights into the reaction kinetics of organic-inorganic lead halide perovskite nanocrystals (LHP NCs) are still limited due to their ultrafast formation rate. Herein, we develop a water-oil interfacial synthesis of MAPbBr NCs (MA=CH NH ), which prolongs the reaction time to tens of minutes. This method makes it possible to monitor in situ the formation process of MAPbBr NCs and observe successive spectral evolutions from 438 to 534 nm in a single reaction by extending reaction time.

[Size Distributions of Aerosol During the Summer at the Summit of Mountain Taishan (1534 m) in Central East China].

In this study, the size distribution of aerosol number concentration (10 nm-10μm), particulate matter (PM and PM), and meteorological data were collected from June 1 to 25, 2017, at the summit of Mountain Taishan by using a wide-range particle spectrometer (WPS), a -ray continuous ambient particulate monitor, and an automatic weather station. Consequently, the characteristic of the aerosol size distribution and their impact factors were analyzed. The results indicated that the average mass concentration of PM and PM were 20.