Multi-Functional Bio-HJzyme Engineered Polyetheretherketone Implant with Cascade-Amplification Therapeutic Capabilities Toward Intractable Implant-Associated Infections.

Intractable implant-associated infections (IAIs) are the primary cause of prosthetic implant failure, particularly in the context of diabetes mellitus. There is an urgent need to design and construct versatile engineered implants integrated with cascade amplification therapeutic modality to significantly improve the treatment of diabetic IAIs. To address this issue, a multi-functional MXene/AgPO@glucose oxidase bio-heterojunction enzyme (M/A@GOx bio-HJzyme) coating is developed, which is decorated with an inert sulfonated polyetheretherketone implant (SP-M/A@G) via hydrothermal treatment and layered deposition.

CRISPR/Cas12a-Triggered Visible-Light-Driven Photoelectrochemical Assay with Single-Nucleotide Resolution for Drug-Resistant Foodborne Detection.

The prevalence of foodborne pathogenic bacteria, especially drug-resistant strains, such as , poses serious threats to public health, highlighting the requirement for the development of rapid and precise detection methods. Herein, a CRISPR/Cas12a-triggered visible-light-driven photoelectrochemical (PEC) assay (CasPEC) was developed using a SiO-quenched BiVO/MoS p/n-type heterojunction as the photoactive material. The CRISPR/Cas12a recognition endowed the CasPEC assay with high specificity capable of resolving single-nucleotide polymorphisms (SNPs) and identifying SNP-involved drug-resistant bacteria.

Metal element-fusion peptide heterostructured nanocoatings endow polyetheretherketone implants with robust anti-bacterial activities and osseointegration.

Polyetheretherketone (PEEK), renowned for its exceptional mechanical properties and bio-stability, is considered a promising alternative to traditional metal-based implants. However, the inferior bactericidal activity and the limited angiogenic and osteogenic properties of PEEK remain the three major obstacles to osseointegration . To overcome these obstacles, in this work, a versatile heterostructured nanocoating was conceived and equipped on PEEK.

Fluorescence Sensing Mechanisms of Versatile Graphene Quantum Dots toward Commonly Encountered Heavy Metal Ions.

Graphene quantum dots (GQDs) have received tremendous attention as fluorescent probes for detection of diverse heavy metal ions (HMIs). Nevertheless, the fluorescence sensing mechanisms of versatile GQDs with respect to different HMIs remain elusive. Herein, the fluorescence sensing behaviors and mechanisms of GQDs with amino and carboxyl groups toward commonly encountered Cr, Fe, Cu, Cr, Mn, Co, Ni, Zn, Cd, and Hg under different pH conditions are systemically explored.

Programmable Multifunctional Gels with On-Demand Patterning Capability toward Hierarchical and Multi-Dimensional Encryption and Anti-Counterfeiting.

Hydrogels capable of optical switching have recently become one of the most celebrated materials for information encryption and anti-counterfeiting. However, challenges still remain for developing versatile gel-based platforms with on-demand multistage patterning and multi-dimensional encryption capacities as well as long-term stability. Herein, elaborately designed programmable and multifunctional gels with fascinating anti-swelling (swelling ratios < 0.

Redox-responsive carrier based on fluorinated gemini amphiphilic polymer for combinational cancer therapy.

Polymeric micelle has emerged as an efficient implement to overcome the shortcomings of conventional cancer chemotherapy due to its superior solubility of hydrophobic drugs and less side effects of drugs. However, insufficient dilution resistance and ordinary therapeutic effect severely restrict the further translation of current drug-loaded polymeric micelles. Here, we showed that well-defined G-Fn (n = 5, 9, 13) polymeric micelles possessed excellent capabilities as a drug carrier in light of high drug loading content, high stability and precise drug release combined with wonderful endocytosis efficiency to tumors.

Mechanisms behind excitation- and concentration-dependent multicolor photoluminescence in graphene quantum dots.

Despite numerous efforts, the mechanism behind multicolor photoluminescence (PL) in graphene quantum dots (GQDs) is still controversial. A deep insight into the origin of the multicolor emissions in GQDs is quite necessary for modulating their luminescence to facilitate the better use of this fluorescent material. Herein, GQDs with amino, carboxyl, and ammonium carboxylate groups were synthesized.

Aqueous Self-Assembly of Y-Shaped Amphiphilic Block Copolymers into Giant Vesicles.

The preparation and aqueous self-assembly of newly Y-shaped amphiphilic block polyurethane (PUG) copolymers are reported here. These amphiphilic copolymers, designed to have two hydrophilic poly(ethylene oxide) (PEO) tails and one hydrophobic alkyl tail via a two-step coupling reaction, can self-assemble into giant unilamellar vesicles (GUVs) (diameter ≥ 1000 nm) with a direct dissolution method in aqueous solution, depending on their Y-shaped structures and initial concentrations. More interesting, the copolymers can self-assemble into various distinct nano-/microstructures, such as spherical micelles, small vesicles, and GUVs, with the increase of their concentrations.