Pharmacological interventions for addressing pediatric and adolescent obesity: A systematic review and network meta-analysis.

Background: Obesity significantly impacts the health outcomes of children and adolescents, necessitating a comprehensive study to evaluate the effects of various anti-obesity medications (AOMs) on weight-related and metabolic outcomes.

Methods: PubMed, EMBASE, and CENTRAL were searched for studies published up to January 3, 2024. We performed a network meta-analysis on randomized clinical trials that compared various treatments for pediatric and adolescent obesity, such as phentermine/topiramate, semaglutide, exenatide, liraglutide, topiramate, metformin, fluoxetine, metformin/fluoxetine, sibutramine, and orlistat.

Identification of two rare variants in two Chinese families with familial focal epilepsy with variable foci 3: NGS analysis with literature review.

The GAP Activity Towards Rags 1 (GATOR1) complex, which includes DEPDC5, NPRL2, and NPRL3, plays a key role in epilepsy. It has been reported that focal epilepsy is associated with mutations in the gene in some cases. We report two rare mutations in the gene in two unrelated Chinese families with focal epilepsy in this study.