Publications by authors named "Shuangqing Chang"
Article Synopsis
- The study explores the genetic relationship between inflammatory bowel disease (IBD) and conjunctivitis, suggesting that they may be linked by shared genetic factors.
- Utilizing genome-wide association study (GWAS) data, various statistical methods, including Mendelian randomization and multi-trait analysis, were employed to identify genetic overlaps between IBD (Crohn's disease and ulcerative colitis) and conjunctivitis.
- Findings indicate a significant correlation primarily on chromosome 11, supporting the idea of genetic co-morbidity and enhancing the understanding of the relationship between these two conditions.
Background: Circulating cytokines play a crucial role in the onset and progression of immune skin diseases. However, the causal relationships and the direction of causal effects require further investigation.
Methods: Two-sample Mendelian randomization (MR) analyses were conducted to assess the causal relationships between 41 circulating cytokines and six immune skin diseases including alopecia areata, chloasma, hidradenitis suppurativa (HS), lichen planus (LP), seborrheic dermatitis, and urticaria, using summary statistics from genome-wide association studies.
Background: Prior observational studies have identified a relationship between the composition of gut microbiota and the onset of acne. To ascertain the causal relationship underlying this association, we adopted the Mendelian randomization (MR) method, which offers a powerful approach to causal inference.
Methods: Summary statistics on gut microbiota and acne were obtained from the MiBioGen and FinnGen consortium, respectively.
Colon adenocarcinoma (COAD), one of the common clinical cancers, exhibits high morbidity and mortality, and its pathogenesis and treatment are still underdeveloped. Numerous studies have demonstrated the involvement of bile acids in tumour development, while the potential role of their metabolism in the tumor microenvironment (TME) has not been explored. A collection of 481 genes related to bile acid metabolism were obtained, and The Cancer Genome Atlas-based COAD risk model was developed using the least absolute shrinkage selection operator (LASSO) regression analysis.
View Article and Find Full Text PDFBackground: Previous studies have suggested the association between interstitial lung disease (ILD) and inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC).
Objectives: To examine the potential bidirectional causal relationship between IBD and ILD using the Mendelian randomization (MR) method.
Methods: We obtained the data from the genome-wide association studies (GWASs) in European individuals for IBD (25,042 cases and 34,915 controls) and ILD (21,806 cases and 196,986 controls) from the IEU GWAS database.
Colorectal cancer (CRC) is the third most prevalent one in the world among the most common malignant tumors. Numerous studies have shown that butyrate has demonstrated promise as an antitumor agent in a variety of human cancer types. However, butyrate remains understudied in CRC tumorigenesis and progression.
View Article and Find Full Text PDFObjective: To systematically evaluate the efficacy of platelet-rich plasma (PRP) in treating anal fistula.
Methods: PubMed, EMBASE, and Cochrane Library databases were systematically searched for randomized controlled studies (RCTs) and case-control studies published before June 2021 on evaluating the efficacy of platelet-rich plasma (PRP) in treating anal fistula. References of the journals were manually searched for relevant studies.