A Three-Parameter Weibull Distribution Method to Determine the Fracture Property of PMMA Bone Cement.

Poly (methyl methacrylate) (PMMA) bone cement is an excellent biological material for anchoring joint replacements. Tensile strength ft and fracture toughness KIC have a considerable impact on its application and service life. Considering the variability of PMMA bone cement, a three-parameter Weibull distribution method is suggested in the current study to evaluate its tensile strength and fracture toughness distribution.

LncRNA MSC-AS1 promotes osteogenic differentiation and alleviates osteoporosis through sponging microRNA-140-5p to upregulate BMP2.

This study aims to explore the role of lncRNA MSC-AS1/microRNA-140-5p/BMP2 regulatory loop in promoting osteogenic differentiation of BMSCs. BMSCs were isolated from bone marrow of mice. Expression levels of MSC-AS1, microRNA-140-5p and BMP2 during osteogenic differentiation were detected by qRT-PCR.

Combined mechanical process recycling technology for recovering copper and aluminium components of spent lithium-iron phosphate batteries.

The recycling processes of spent lithium iron phosphate batteries comprise thermal, wet, and biological and mechanical treatments. Limited research has been conducted on the combined mechanical process recycling technology and such works are limited to the separation of metal and non-metal materials, which belongs to mechanical recovery. In this article the combined mechanical process recycling technology of spent lithium iron phosphate batteries and the separation of metals has been investigated.

[Progress on treatment for stenosing tenosynovitis].

Radial styloid stenosing tenosynovitis is a kind of common chronic motor system injuries, and could lead to joint pain and aggravates with activity, in further makes a great impact on people's daily life. At present, therapeutic methods for this disease could divid into conservative treatment and surgical treatment. What we pay attention to is cure.

Pneumatic separation and recycling of anode and cathode materials from spent lithium iron phosphate batteries.

A novel approach to recycling of copper and aluminum fragments in the crushed products of spent lithium iron phosphate batteries was proposed to achieve their eco-friendly processing. The model of pneumatic separation that determines the optimal airflow velocity was established using aerodynamics. The influence of the airflow velocity, and the density and thickness, and their ratios, of the aluminum and copper fragments on pneumatic separation were evaluated.

In Situ Fabrication of Defective CoN Single Clusters on Reduced Graphene Oxide Sheets with Excellent Electrocatalytic Activity for Oxygen Reduction.

A facile one-step strategy for anchoring defective CoN single clusters on partly reduced graphene oxide (RGO) is constructed to significantly improve the catalytic performance of non-noble metal complexes toward oxygen reduction reaction (ORR). Sequent loading with trace amounts of metal-free porphyrin and Co in RGO can dramatically enhance both the half-wave potential and the peak current density. Intriguingly, the RGO/P/2Co single cluster exhibits the best ORR catalytic performance with the half-wave potential of 0.

Architecture of CoN single clusters on nanocarbon as excellent oxygen reduction catalysts with high-efficient atomic utilization.

A new strategy to fabricate CoN single cluster supported nanocarbon catalysts (C/P/2Co600) with enhanced atomic utilization towards the oxygen reduction reaction (ORR) is reported. N-Coordination protection and low-temperature pyrolysis are the two key factors for the formation of CoN single clusters on nanocarbon supports. Morphological and structural identification confirmed the simultaneous anchoring of homo-dispersed CoN single clusters and N-doping on the nanocarbon under relatively mild thermal treatment conditions.

Edaravone protects against oxygen-glucose-serum deprivation/restoration-induced apoptosis in spinal cord astrocytes by inhibiting integrated stress response.

We previously found that oxygen-glucose-serum deprivation/restoration (OGSD/R) induces apoptosis of spinal cord astrocytes, possibly caspase-12 and the integrated stress response, which involves protein kinase R-like endoplasmic reticulum kinase (PERK), eukaryotic initiation factor 2-alpha (eIF2α) and activating transcription factor 4 (ATF4). We hypothesized that edaravone, a low molecular weight, lipophilic free radical scavenger, would reduce OGSD/R-induced apoptosis of spinal cord astrocytes. To test this, we established primary cultures of rat astrocytes, and exposed them to 8 hours/6 hours of OGSD/R with or without edaravone (0.

HSP70 desensitizes osteosarcoma cells to baicalein and protects cells from undergoing apoptosis.

Baicalein is a new drug that has shown promising anti-cancer effects against a broad spectrum of tumors. However, the potential effect on osteosarcoma cells and the mechanisms involved are still largely unknown. Resistance to chemotherapy remains a major obstacle in cancer therapy.

Wnt5a promotes migration of human osteosarcoma cells by triggering a phosphatidylinositol-3 kinase/Akt signals.

Wnt5a is classified as a non-transforming Wnt family member and plays complicated roles in oncogenesis and cancer metastasis. However, Wnt5a signaling in osteosarcoma progression remains poorly defined. In this study, we found that Wnt5a stimulated the migration of human osteosarcoma cells (MG-63), with the maximal effect at 100 ng/ml, via enhancing phosphorylation of phosphatidylinositol-3 kinase (PI3K)/Akt.