Characterization of alternatively spliced transcript variants of glycophorin A and glycophorin B genes in Chinese blood donors.

Background And Objectives: The molecular basis of MNS blood group variants is not fully clear yet. In this study, we have characterized mRNA variants of GYPA and GYPB genes to reveal whether alternative RNA splicing may cause antigenic diversity of the MNS system.

Materials And Methods: Total RNA was extracted from peripheral blood of Chinese blood donors and full-length cDNA products were generated.