Identification of terpenoids from Rubus corchorifolius L. f. leaves and their anti-proliferative effects on human cancer cells.

The leaves of Rubus corchorifolius L. f. have been consumed as a herbal tea for a long time.

Identification of pinostilbene as a major colonic metabolite of pterostilbene and its inhibitory effects on colon cancer cells.

Scope: Pterostilbene (PTE) is a resveratrol derivative mainly found in blueberries, and it has been shown to inhibit colon carcinogenesis in multiple animal models. To shed light on the mechanism of PTE in inhibiting colon carcinogenesis, we investigated the PTE metabolites in the mouse colon and in the human colon cancer cells.

Methods And Results: CD-1 mice were fed PTE-containing diet for 3 weeks, and colonic content and colonic mucosa were collected and subjected to LC-MS analysis.

Anti-inflammatory effects of 4'-demethylnobiletin, a major metabolite of nobiletin.

Nobiletin, a citrus flavonoid has been associated with various beneficial biological activities. 4'-Demethylnobiletin (4DN) is a major metabolite of nobiletin and its tissue level was found to be much higher than that of nobiletin after oral administration of nobiletin in mice. Anti-inflammatory effects of 4DN were studied in lipopolysaccharide (LPS)-treated RAW 264.

[Studies on the chemical components and antibacterial activity of essential oil from the leaves of Rubus corchorifolius].

Objective: To analyze the chemical components of essential oil from the leaves of Rubus corchorifolius.

Methods: The essential oil was extracted by steam distillation, and then an analysis was conducted by applying GC-MS and Xcalibur Software. K-B filter paper method was used for their bacteriostasish.