Objectives: To explore the effects of trigeminal neuralgia on neurodegeneration in rats and the underlining mechanism.
Methods: Sixty adult male Sprague Dawley rats were divided randomly into Chronic Constriction Injury of the Rat’s Infraorbital Nerve (ION-CCI) group and sham group ( = 30). Right suborbital nerve was ligated in ION-CCI group to establish a trigeminal neuralgia model.