Multifunctional SEBS/AgNWs Nanocomposite Films with Antimicrobial, Antioxidant, and Anti-Inflammatory Properties Promote Infected Wound Healing.

Wound healing is a complex biological process that can trigger inflammation and oxidative stress and impair myofibrillogenesis and angiogenesis. Several advanced wound-dressing nanocomposite materials have been designed to address these issues. Here, we designed a new multifunctional styrene-ethylene-butylene-styrene/silver nanowire (SEBS/AgNWs)-based nanocomposite film with antimicrobial, antioxidant, and anti-inflammatory properties to promote wound healing.

Optimizing stormwater runoff treatment: The role of two-stage tandem rain gardens.

Regarded as a superior urban stormwater management solution, rain gardens can effectively store rainfall runoff and purify water quality. However, the efficiency of traditional rain gardens (TRG) in regulating runoff and removing nitrogen and phosphorus varies under different hydrological conditions. In this study, the TRG was retrofitted to construct a two-stage tandem rain garden (TTRG).

The effect of flow partition on storm runoff and pollutant retention through raingardens with and without subsurface drainage.

Green infrastructures (GIs) have been advocated worldwide to mitigate the negative impact of urbanization on regional hydrological cycle, their functions are closely related to their design features and the local environmental condition. This paper reports a field monitoring study that aimed to investigate how runoff partition in raingardens would affect flow and pollutant retention. A paired field experiment was conducted to compare runoff and pollutant retentions in two raingardens with and without subsurface drainage in a shallow water table area.

Compositional tuning of epoxide-polyetheramine "click" reaction toward cytocompatible, cationic hydrogel particles with antimicrobial and DNA binding activities.

Unlabelled: The "click" characteristics of nucleophilic opening of epoxide have recently been exploited for the development of a functional hydrogel particle system based on commercially available bisepoxide and triamine polyetheramine monomers. Key features of these particles include high cationic charges and responsiveness to temperature, pH, and oxidation. Despite these advantages, the cytocompatibility of these particles must be considered prior to use in biomedical applications.

Facile Use of Cationic Hydrogel Particles for Surface Modification of Planar Substrates Toward Multifunctional Neural Permissive Surfaces: An in Vitro Investigation.

Synthetic materials such as silicon have been commonly used for neural interfacing applications but are intrinsically noninteractive with neurons. Here, a facile approach has been developed to integrate both chemical and topographical cues to impart neural permissiveness for such materials. The approach simply exploits the basic phenomenon of electrostatically driven adsorption of colloidal particles onto a solid material and applies it to a cationic hydrogel particle system that we have developed recently based on "click" reaction of epoxide and amine.

Water-based synthesis of cationic hydrogel particles: effect of the reaction parameters and in vitro cytotoxicity study.

Micro/nanoscale hydrogel particles are of great interest for biomedical applications, such as carriers for therapeutic delivery. Compared to conventional hydrogel particles that are mainly composed of vinylic monomers, we have introduced a simple methodology to prepare multi-functional cationic hydrogel particles by adopting the epoxy-amine chemistry in water exemplifying "click" characteristics. Herein, we investigate the effects of key reaction parameters, including time, temperature, reactant concentration and amine-epoxy stoichiometric ratio, on the preparation and properties of such hydrogel particles.

Agarose hydrogels embedded with pH-responsive diblock copolymer micelles for triggered release of substances.

Hybrid agarose hydrogels embedded with pH-responsive diblock copolymers micelles were developed to achieve functional hydrogels capable of stimulus-triggered drug release. Specifically, a well-defined poly(ethylene oxide) (PEO)-based diblock copolymer, PEO-b-poly(2-(N,N-diisopropylamino)ethyl methacrylate) (PEO(113)-b-PDPAEMA(31), where the subscripts represent the degrees of polymerization of two blocks), was synthesized by atom transfer radical polymerization. PDPAEMA is a pH-responsive polymer with a pKa value of 6.

Facile aqueous-phase synthesis of multi-responsive nanogels based on polyetheramines and bisepoxide.

A new strategy for the preparation of nanogels from commercially available monomers of bisepoxide and aliphatic polyetheramine has been developed. The nanogels are generated in a one-pot process through aggregation polymerization of an in situ formed thermal sensitive intermediate polymer in an additive-free and catalyst-free aqueous environment. Such a facile process allows easy size tuning of the gel particles from the nanometer to the micron scale, simply by adjusting the reactant concentration.