Hepatic artery pseudoaneurysm caused by chronic pancreatitis: Case report and literature review.

Rationale: Visceral artery pseudoaneurysm is a rare complication of chronic pancreatitis (CP), all pancreatic or peripancreatic arteries have been reported to be involved, while hepatic artery is less common.

Patient Concerns: This case report illustrated a 42-year-old man with CP who developed right hepatic artery pseudoaneurysm (HAP), and finally he was treated with intravascular embolization.

Diagnoses: The patient suffered from HAP due to acute attack of CP.

Modeling multimedia fate and health risk assessment of polycyclic aromatic hydrocarbons (PAHs) in the coastal regions of the Bohai and Yellow Seas.

Using an improved multimedia fate model, this study simulated the spatial distributions, partitioning behaviors, and mass exchanges of PAH (16 species with priority by the USEPA) in multiple environmental compartments in the coastal regions of the Bohai and Yellow Seas, Northern China. The model predictions generally matched well with the measured results, as the deviations of most points were within one order of magnitude in the air, freshwater, and 3 soil compartments. The estimated concentrations of ΣPAH in the northern part were higher than those in the southern part, which was consistent with the emissions of each part.

Dual polymeric prodrug co-assembled nanoparticles with precise ratiometric co-delivery of cisplatin and metformin for lung cancer chemoimmunotherapy.

The combination therapy of cisplatin (CDDP) and metformin (MET) is a clinical strategy to enhance therapeutic outcomes in lung cancer. However, the efficacy of this combination is limited due to the asynchronous pharmacokinetic behavior of CDDP and MET, used as free drugs. Therefore, in this work, hyaluronic acid-cisplatin/polystyrene-polymetformin (HA-CDDP/PMet) dual-prodrug co-assembled nanoparticles were developed, with precise ratiometric co-delivery of CDDP and MET for chemo-immunotherapy against lung cancer.

Tumor Microenvironment-Triggered Charge Reversal Polymetformin-Based Nanosystem Co-Delivered Doxorubicin and IL-12 Cytokine Gene for Chemo-Gene Combination Therapy on Metastatic Breast Cancer.

Cancer metastasis is the leading cause of high mortality and disease recurrence in breast cancer. In this study, a novel tumor microenvironment charge reversal polymetformin (PMet)-based nanosystem co-delivering doxorubicin (DOX) and plasmid encoding IL-12 gene (pIL-12) was developed for chemo-gene combination therapy on metastatic breast cancer. Cationic PMet was readily self-assembled into micelles for DOX physical encapsulation and pIL-12 complexation, and a hyaluronidase-sensitive thiolated hyaluronic acid (HA-SH) was then collaboratively assembled to the pIL-12/DOX-PMet micelleplexes, abbreviated as HA/pIL-12/DOX-PMet.

Codelivered Chemotherapeutic Doxorubicin a Dual-Functional Immunostimulatory Polymeric Prodrug for Breast Cancer Immunochemotherapy.

Immunochemotherapy is viewed as a promising approach for cancer therapy combination treatment with immune-modulating drugs and chemotherapeutic drugs. A novel dual-functional immunostimulatory polymeric prodrug carrier PEG-Fmoc-1-MT was developed for simultaneously delivering 1-methyl tryptophan (1-MT) of an indoleamine 2,3-dioxygenase (IDO) inhibitor and chemotherapeutic doxorubicin (DOX) for breast cancer immunochemotherapy. DOX/PEG-Fmoc-1-MT micelles were more effective in cell proliferation inhibition and apoptosis induction in 4T1 cells.

Occurrence, source, and risk assessment of atmospheric parent polycyclic aromatic hydrocarbons in the coastal cities of the Bohai and Yellow Seas, China.

Parent polycyclic aromatic hydrocarbons (PPAHs) in the ambient air of the coastal cities near the Bohai and Yellow Seas were measured over a full year. The range and geometric average of total PPAH (29 species) were 5.16-1.

Effects of temperature on the emission of particulate matter, polycyclic aromatic hydrocarbons, and polybrominated diphenyl ethers from the thermal treatment of printed wiring boards.

The effects of temperature on the emission of pollutants during the thermal treatment of electronic waste have rarely been investigated. The emission of particulate matter (PM), polycyclic aromatic hydrocarbons (PAHs), and polybrominated diphenyl ethers (PBDEs) from the thermal treatment of printed wiring boards was investigated over a temperature range of 320-600 °C. The emission factors (EFs) were determined to be within 1.

Characteristics and human inhalation exposure of ionic per- and polyfluoroalkyl substances (PFASs) in PM of cities around the Bohai Sea: Diurnal variation and effects of heating activity.

Atmospheric PM (particulate matter with aerodynamic diameter <10 μm) samples were collected in the cities along the Bohai Sea Rim during heating and non-heating periods, and ionic per- and polyfluoroalkyl species (PFASs) in the PM were measured. The total concentration of ionic PFASs ranged from 21.8 to 87.

Co-Delivery of Paclitaxel by a Capsaicin Prodrug Micelle Facilitating for Combination Therapy on Breast Cancer.

Poor anticancer ability, serious adverse reaction, and drug resistance against paclitaxel (PTX) have limited its clinical applications. When a mouse breast carcinoma cell line (4T1) was treated with both PTX and capsaicin (CAP), there was a synergistic anti-proliferative effect demonstrated with a combination index of 0.28.

Multifunctionalized Micelles Facilitate Intracellular Doxorubicin Delivery for Reversing Multidrug Resistance of Breast Cancer.

Intracellular doxorubicin (DOX) pumping out of cells through the P-glycoprotein (P-gp) transporter leads to the reduction of intracellular DOX levels and induces multidrug resistance (MDR). A hyaluronic acid-deoxycholic acid-histidine and Pluronic F127 (PF127) mixed micellar system, named HA-DOCA-His-PF micelles, functionalized with active targeted endocytosis mediated via CD44 receptor, intracellular triggered DOX release under endosome-pH, and combined with PF127-mediated P-gp efflux inhibition was developed for sufficient intracellular DOX delivery and MDR reversion. The DOX/HA-DOCA-His-PF drug-loaded micelles displayed endosomal pH-mediated self-assembly/disassembly characteristics, triggered DOX release under an endosomal (pH 5.

Emission factors of particulate matter, CO and CO in the pyrolytic processing of typical electronic wastes.

A self-designed experimental device was employed to simulate the pyrolytic dismantling process of selected electronic wastes (E-wastes), including printed wiring boards (PWBs) and plastic casings. The generated particulate matter (PM) of different particle sizes, carbon monoxide (CO) and carbon dioxide (CO) were determined, and the corresponding emission factors (EFs) were estimated. Finer particles with particle sizes of 0.

Emission behaviors of nitro- and oxy-polycyclic aromatic hydrocarbons during pyrolytic disposal of electronic wastes.

Emission factors (EFs) of polycyclic aromatic hydrocarbon (PAH) derivatives (12 nitro-PAHs and 4 oxy-PAHs) during the pyrolysis of two types of electronic waste (E-waste) were measured. Compositional profile, particle size distribution, gas-particle partitioning, correlations with precursor species and influences of pyrolytic temperature were investigated. The derivative products were dominated by oxy-PAHs.

Characteristics of perfluoroalkyl acids in atmospheric PM from the coastal cities of the Bohai and Yellow Seas, Northern China.

The concentration distributions, compositional profiles and seasonal variations of 17 perfluoroalkyl acids (PFAAs) in PM (particles with aerodynamic diameters < 10 μm) were determined in seven coastal cities of the Bohai and Yellow Seas. The detection rates of perfluorooctanoic acid (PFOA) and short-chain components (perfluoroalkyl carboxylic acids (PFCAs) with ≤7 carbon atoms and perfluoroalkane sulfonic acids (PFSAs) with ≤5 carbon atoms) were much higher than those of other long-chain PFAA species. The annual average concentration of total PFAAs in PM ranged from 23.

Characteristics and oxidative potential of atmospheric PM in Beijing: Source apportionment and seasonal variation.

Unlabelled: PM (particulate matter with the aerodynamic diameter D < 2.5 μm) was hypothesized to generate reactive oxygen species (ROS) and induce oxidative stress associated with inflammation and cardiovascular diseases. In the current study, PM concentrations, water-soluble ions and elements, carbonaceous components and ROS activity characterized by the dithiothreitol (DTT) assay were determined for the PM samples collected in Beijing, China, over a whole year.

Emission characteristics of polycyclic aromatic hydrocarbons from pyrolytic processing during dismantling of electronic wastes.

Two typical types of electronic waste (E-waste) were selected to investigate the emission characteristics of polycyclic aromatic hydrocarbons (PAHs) during pyrolytic processing, including emission factor, compositional profile, size distribution and gas-particle partitioning. The mean emission factors (EFs) of total PAHs were measured to be 2.77 ± 1.

Oxidative potential of ambient PM in the coastal cities of the Bohai Sea, northern China: Seasonal variation and source apportionment.

Emissions of air pollutants from primary and secondary sources in China are considerably higher than those in developed countries, and exposure to air pollution is main risk of public health. Identifying specific particulate matter (PM) compositions and sources are essential for policy makers to propose effective control measures for pollutant emissions. Ambient PM samples covered a whole year were collected from three coastal cities of the Bohai Sea.

PBDE emission from E-wastes during the pyrolytic process: Emission factor, compositional profile, size distribution, and gas-particle partitioning.

Polybrominated diphenyl ether (PBDE) pollution in E-waste recycling areas has garnered great concern by scientists, the government and the public. In the current study, two typical kinds of E-wastes (printed wiring boards and plastic casings of household or office appliances) were selected to investigate the emission behaviors of individual PBDEs during the pyrolysis process. Emission factors (EFs), compositional profile, particle size distribution and gas-particle partitioning of PBDEs were explored.

[Effects of a comprehensive intervention program on simple obesity of children in kindergarten].

Objective: The purpose of the study was to explore a comprehensive management program for the obese children in kindergarten. The program should be scientific, rational, suitable for kindergarten, and easy to apply. Child care workers, parents, and child health care doctors participated in the program to help obese children establish a scientific life style through their daily life, to control their weight and to maintain their physical and mental health.