Publications by authors named "Shuang-xi Zhang"
Article Synopsis
- Previous studies show a strong link between cholesterol-to-lipid ratio in medium VLDL and peptic ulcers, but the exact cause-and-effect relationship is still unclear.
- This study aims to clarify this association using genetic methods, specifically focusing on how the cholesterol-to-lipid ratio in VLDL relates to the incidence of peptic ulcers.
- Researchers used genome-wide association studies to identify genetic variations associated with the cholesterol ratio, employing several analytical methods, including forward and inverse Mendelian randomization, to assess potential causal relationships and ensure result reliability.
Phosphate deficiency and drought are significant environmental constraints that impact both the productivity and quality of wheat. The interaction between phosphorus and water facilitates their mutual absorption processes in plants. Under conditions of both phosphorus deficiency and drought stress, we observed a significant upregulation in the expression of wheat MYB-CC transcription factors through the transcriptome analysis.
View Article and Find Full Text PDFType one autoimmune pancreatitis based on clinical diagnosis: A case report.
World J Clin Cases
May 2024
Article Synopsis
- * The patient presented with jaundice and imaging indicated pancreatic swelling, with elevated serum IgG4 levels confirming the diagnosis of AIP and related conditions.
- * After hormonal treatment, the patient's symptoms and imaging results improved, highlighting the effectiveness of appropriate therapy for AIP.
Article Synopsis
- Bacterial wilt, a serious disease caused by a major phytopathogen, leads to significant losses in crop yields, largely due to the ability of the pathogen's Type III effectors (T3Es) to disrupt plant immune responses.
- The study focused on the novel T3E, RipAW, demonstrating its role in suppressing plant immunity by targeting key immune receptor proteins (FLS2, XLG2, BIK1) through a process of ubiquitination and degradation.
- The findings reveal that RipAW weakens the plant's defense mechanisms, offering new perspectives on how the pathogen can enhance its virulence.
Adaptation to drought and salt stresses is a fundamental part of plant cell physiology and is of great significance for crop production under environmental stress. Heat shock proteins (HSPs) are molecular chaperones that play a crucial role in folding, assembling, translocating, and degrading proteins. However, their underlying mechanisms and functions in stress tolerance remain elusive.
View Article and Find Full Text PDFArticle Synopsis
- - Yiqi Huoxue Decoction (YQHXD) is a traditional Chinese medicine that treats nephrotic syndrome by promoting blood circulation and relieving edema, but its active ingredients and mechanisms are not fully understood.
- - Researchers utilized Ultra-High Performance Liquid Chromatograph-Mass (UPLC-MS) to identify 233 compounds in YQHXD and 50 that enter the bloodstream, forming a Disease-Drug-Ingredient-Gene (DDIG) network and conducting various pathway analyses.
- - The study found 36 key targets linked to specific signaling pathways, with compounds like Luteolin and Wogonin highlighted as potentially active, ultimately demonstrating that YQHXD can improve renal function and reduce kidney
Article Synopsis
- Haploid induction is a key technique in crop breeding, focusing on improving haploid induction rates and simplifying procedures to create new crop varieties efficiently.* -
- The integration of haploid breeding with other methods like crossing, mutation, and molecular markers boosts breeding effectiveness and accelerates the development of homozygous traits.* -
- This review covers advancements in haploid induction technologies, particularly involving genome editing, and discusses future challenges and opportunities in utilizing these techniques for better crop improvements.*
Article Synopsis
- The YABBY gene family is crucial for plant growth and development, with 17 YABBY genes identified in the soybean genome, located across 11 chromosomes.
- Analysis showed that these genes contain key regulatory elements and are sensitive to abiotic stresses like drought and salt.
- Specifically, GmYABBY10 was found to potentially inhibit plant resistance to drought and salt stress, as transgenic Arabidopsis with this gene had lower survival rates and smaller roots compared to wild type plants under stress conditions.
Article Synopsis
- High-resolution and wide-swath synthetic aperture radar (SAR) is critical for modern remote sensing but faces challenges in balancing high resolution and low pulse repetition frequency.
- The paper introduces a robust channel-calibration algorithm using weighted minimum entropy to improve imaging in multi-channel azimuth SAR systems, addressing channel mismatches.
- This algorithm involves a two-step process to correct timing and amplitude mismatches, followed by retrieving residual phase mismatches, and is validated through simulations and real-world data.
[Application of the island flap at the dorsum of the middle phalange with the pedicel of the digital proper artery].
Zhonghua Zheng Xing Wai Ke Za Zhi
September 2011
Article Synopsis
- - The study investigates a surgical technique using an island flap to treat skin defects on the distal phalanges of fingers, specifically from the 2nd to 5th fingers.
- - Over a period of five years, 54 patients with 61 affected fingers underwent this procedure, with outcomes showing complete survival of all flaps and good recovery in terms of texture, color match, and sensation.
- - The island flap method was found to be effective and resulted in normal movement of the finger joints, making it a recommended approach for dealing with these types of injuries.
Article Synopsis
- The hematopoietic system in mice develops from mesoderm that migrates to the yolk sac around day 7 of gestation, but the exact mechanisms behind this process are not well understood.
- Research shows that hematopoietic precursors from embryonic stem (ES) cells develop similarly to those in yolk sacs, making it easier to study potential treatments for blood disorders through in vitro differentiation.
- This study focuses on high proliferative potential colony-forming cells (HPP-CFC) found in embryoid bodies (EBs) and reveals that while they can form various blood cell types, their development varies with different serum conditions and differs from adult bone marrow progenitors.
Article Synopsis
- The study aimed to evaluate the therapeutic effects of treating collapsed and comminuted distal radius fractures in 26 hospitalized patients from 1998 to 2003.
- The treatment involved open reduction, sustained bone grafting, and the use of a joint external fixator, which helped restore the anatomical shape of the radius.
- Results indicated successful fracture healing with no length discrepancies, intact joint surfaces, and a majority rated as excellent or good based on the Dieust criterion.
Article Synopsis
- Mesenchymal stem cells (MSCs) have been shown to inhibit the differentiation of monocytes into dendritic cells (DCs), the key antigen-presenting cells in the immune system, in vitro.
- This suppression can occur even without direct contact between MSCs and monocytes, depending on their relative concentrations.
- Furthermore, MSC-treated mature DCs exhibit reduced expression of important molecules for T-cell activation, indicating that MSCs may play a significant role in modulating the immune response by influencing early stages of cell differentiation.
[Establishment of a Human Umbilical Vein Endothelial Cell Line Supporting Hematopoiesis In Vitro].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
March 2001
Article Synopsis
- Endothelial cells play a crucial role in the hematopoietic microenvironment, and a human umbilical vein endothelial cell line, called IEC, was developed to study their effects on blood cell formation.
- The IEC cells were created by transfecting primary human umbilical vein endothelial cells with a specific plasmid, resulting in high expression of factor VIII and a karyotype with some chromosomal variations.
- These IEC cells maintained their ability to grow through at least 25 passages and were found to enhance the growth of granulocyte-macrophage progenitor cells during coculture with cord blood CD34(+) cells, demonstrating their supportive role in hematopoiesis in vitro.
Article Synopsis
- Long-term culture initiating cells (LTC-IC) and hematopoietic stem/progenitor cells from human umbilical cord blood show variability in their growth and response to different growth factors.* -
- Researchers assessed the impact of various stromal feeder layers on the survival and proliferation of LTC-IC through gene modification techniques involving FL and TPO genes.* -
- The study found that bone marrow stromal cells and genetically modified HFCL stromal cells significantly supported LTC-IC cultures, with the HFCL modified with both FL and TPO genes (HFT) proving most effective for long-term maintenance.*