[Imbalance of immunological functions of Treg and TGF-β1 aggravated cerebral ischemia damage in mice].

Aim: To investigate the changes of proportion of CD4(+);CD25(+); regulatory T cells (Treg) in Splenocytes and concentration of serum TGF-β1 in diverse period after transient middle cerebral artery occlusion(tMCAO) in mice and correlation between Treg and TGF-β1, so as to elucidate their roles in the immunological injury of acute ischemic stroke.

Methods: 60 male Kunming mice were randomly divided into six groups, i.e.