Evaluation of Renal Impairment in Patients with Diabetic Kidney Disease by Integrated Chinese and Western Medicine.

Objective: To investigate the factors related to renal impairment in patients with diabetic kidney disease (DKD) from the perspective of integrated Chinese and Western medicine.

Methods: Totally 492 patients with DKD in 8 Chinese hospitals from October 2017 to July 2019 were included. According to Kidney Disease Improving Global Outcomes (KDIGO) staging guidelines, patients were divided into a chronic kidney disease (CKD) 1-3 group and a CKD 4-5 group.

A novel galactose-PEG-conjugated biodegradable copolymer is an efficient gene delivery vector for immunotherapy of hepatocellular carcinoma.

Successful immunogene therapy depends not only on the therapeutic gene but also on the gene delivery vector. In this study, we synthesized a novel copolymer consisting of low-molecular-weight polyethylenimine (PEI) cross-linked by myo-inositol (INO) and conjugated with a galactose-grafted PEG chain, named LA-PegPI. We characterized the chemical structure and molecular weight of the copolymer and particle properties of LA-PegPI/pDNA.

Comprehensive analysis of degradation and accumulation of ametryn in soils and in wheat, maize, ryegrass and alfalfa plants.

Ametryn is a selective herbicide belonging to the triazine family and widely used for killing annual grasses or weeds in China and other parts of the world. However, reports on its environmental risk assessment with regard to soil and crop contamination are limited. In this study, accumulation of ametryn in wheat, maize, ryegrass and alfalfa crops along with ametryn residues in the soil planted with the plants were comparatively investigated.