Network pharmacology prediction and molecular docking-based strategy to explore the pharmacodynamic substances and mechanism of "Mung Bean" against bacterial infection.

Objective: The network pharmacology approach combined the technologies of molecular docking and bacteriostatic validation to explore the active compounds, core targets, and mechanism of against bacterial infection.

Methods: A target and anti-bacterial infection-related gene set was established using TCMSP and GeneCards databases. Gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis and protein-protein interaction network were performed using DAVID and STRING database.

Theoretical investigation on the reaction of adhesion unit dopa in mussel with electrolyzing seawater.

Adhesive proteins secreted by the marine mussel could bind strongly to all kinds of surfaces, for instance, ship hulls and petroleum pipelines. Studies indicated that there was an unusual amino acid 3,4-dihydroxy-l-phenylanine (dopa), which was the crucial super adhesive unit in the proteins. The technology of electrolyzing seawater was employed to generate HOCl solution to hinder the adhesion.