Aqueous Dehydrogenation of Methyl Formate Catalyzed by a Recyclable Polymer-Grafted Manganese(I) Pincer Complex.

Liquid organic hydrogen carriers (LOHCs) are an effective solution for the long-term storage of hydrogen and its long-distance transportation, but one that requires efficient catalysis for hydrogen uptake and release. Homogeneous molecular catalysts employed in LOHC systems usually exhibit high reactivity and selectivity, but are difficult to recover and reuse, a fact that severely limits their practical application. Herein, we report an easily synthesized polymer-grafted pincer-type complex of earth-abundant manganese, which can catalyze the aqueous dehydrogenation of methyl formate, an emerging LOHC material.

Enantioselective Total Synthesis of Fortimicin B.

Fortimicins, featuring with a pseudodisaccharide scaffold, are an unusual class of aminoglycosides with potent efficacy against several aminoglycoside-resistant bacterial strains. Notably, these molecules also exhibit lower inherent ototoxicity and nephrotoxicity than common aminoglycosides. Consequently, fortimicins are a promising type of protypical molecules for the development of the next-generation of aminoglycoside antibiotics.

Updated Insights Into the Mechanism of Salt-Induced Aggregation-Based Single-Molecule Surface-Enhanced Raman Spectroscopy.

Since its discovery in 1997, the single molecule surface-enhanced Raman spectroscopy (SM-SERS) has attracted wide interest owing to its enormous potential in many fields. However, the commercialized applications of SM-SERS are still limited by the lack of a clear understanding of the relevant mechanism in the famous SM-SERS experiments. In this study, a salt-gradient model is proposed to deeply investigate the physical nature and update insights into the morphological, structural, and component evolution processes of Ag NPs from dispersed nanostructures to aggregation states in the salt-induced aggregation SERS strategy.

Efficient Extraction, Chemical Characterization, and Bioactivity of Essential Oil From Pine Needles.

Introduction: Pine needles are a rich source of bioactive compounds, and there are few reports on the extraction and identification of active substances in various types of pine needles.

Objectives: The objective of this study is to enhance the efficiency and yield of pine needle essential oil extraction by employing an innovative ultrasonic-assisted salt-out hydrodistillation technology. It also aims to establish a correlation between gas chromatography-mass spectrometry (GC-MS) and electronic nose (E-nose) to distinguish essential oils from Cedrus deodara, Pinus thunbergii, Pinus massoniana, and Pinus koraiensis.

Tetramethylurea Based Intermediate Phase Engineering for Efficient and Stable Perovskite Solar Cells.

Perovskite solar cells (PSCs) are emerging photovoltaic devices renowned for their high efficiency and low cost. Efficient and stable PSCs depend on high-quality perovskite films, which are strongly influenced by the excellent nucleation and growth. The choice of solvent is critical for the crystallization behavior of perovskite films.

Injectable Nanocomposite Hydrogels for Intervertebral Disc Degeneration: Combating Oxidative Stress, Mitochondrial Dysfunction, and Ferroptosis.

Intervertebral disc degeneration (IVDD) is a major cause of low back pain, where oxidative stress and mitochondrial dysfunction are key contributors. Additionally, ferroptosis, an iron-dependent form of cell death, is identified as a critical mechanism in IVDD pathogenesis. Herein, the therapeutic potential of gallic acid (GA)-derived PGA-Cu nanoparticles, enhanced with functional octapeptide (Cys-Lys-His-Gly-d-Arg-d-Tyr-Lys-Phe, SS08) to build the mitochondria-targeted nanoparticles (PGA-Cu@SS08), and embedded within a hydrogel matrix to form a nanocomposite hydrogel, is explored.

Genome-wide analysis of family genes in and the role of in copper, zinc tolerance.

12-oxo-phytodienoic acid reductase (OPR) is one of the key enzymes in the octadecanoid pathway, and it controls the last step of jasmonic acid (JA) biosynthesis. Although multiple isoforms and functions of s have been identified in various plants, no genes have been identified, and their possible roles in grapevine development and defense mechanisms remain unknown. In this study, nine genes were identified from grapevine genome and classified into two subfamilies.

Patients with AMA/anti-sp100/anti-gp210 Positivity and Cholestasis Can Manifest Conditions Beyond Primary Biliary Cholangitis.

Background And Aims: The diagnostic value of primary biliary cholangitis (PBC)-specific antibodies in patients with elevated alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) levels, and other identifiable causes, was unclear. Our study aimed to determine whether etiological treatments in PBC-specific antibody-positive patients could improve liver biochemical tests, thereby distinguishing them from individuals with PBC.

Methods: We enrolled patients who were positive for PBC-specific antibodies and elevated ALP and/or GGT levels but with other identifiable etiologies.

Role of Ethylene Diamine Tetraacetate as an Additive in Electrolyte on Intermediate Stabilization in Electrochemical CO2 Reduction.

Although an electrochemical CO2 reduction reaction (ECO2RR) can provide an ideal route to produce CH4, its selectivity is significantly hindered due to kinetically complex steps. To improve CH4 selectivity, this study focuses on microenvironmental engineering using an additive of ethylene diamine tetraacetate (EDTA) in electrolyte. EDTA interacts with the Cu catalyst, altering its electronic structure and promoting CO2 activation, in addition, it forms additional hydrogen bonding with key intermediates of *CO and *CHO leading to their stabilization.

Exploring the Core Functional Microbiota Related to Flavor Compounds in Douchi from the Sichuan-Chongqing Region.

Douchi is a traditional Chinese fermented soybean product. In the Sichuan-Chongqing region, -type douchi was particularly famous for its distinctive flavor. Nevertheless, the association between microorganisms and douchi flavor is still poorly understood.

Anti-Hair Loss Effect of Veratric Acid on Dermal Papilla Cells.

The activation of hair follicle dermal papilla cells (HFDPCs), a critical target of hair loss relief, can be achieved through the upregulation of proliferation, the stimulation of hair inducibility, and the inhibition of cellular senescence. Veratric acid (VA) is a major benzoic acid found in fruits and vegetables. The biological activity of VA on HFDPCs remains to be elucidated.

Genome-Wide Exploration and Characterization of the Gene Family's Expression Patterns in Response to Abiotic Stresses in Siberian Wildrye ( L.).

Siberian wildrye ( L.), a model Gramineae plant, has high eco-economic value but limited seed and forage yield. transcription factors are widely regarded as influencing yield and quality and being crucial for growth and development; still, this gene family in Siberian wildrye remains unexplored.

Potential Chondroprotective Effect of L. Water Extract on SW1353 Cell.

Inflammation plays a critical role in the pathogenesis of osteoarthritis (OA). The objective of this study was to investigate the anti-inflammatory and chondroprotective properties of L. water extract (AWE) following the induction of inflammation in cartilage cells (SW1353 cell) through the administration of interleukin-1 beta (IL-1β).

Application of Machine Learning for FOS/TAC Soft Sensing in Bio-Electrochemical Anaerobic Digestion.

This study explores the application of various machine learning (ML) models for the real-time prediction of the FOS/TAC ratio in microbial electrolysis cell anaerobic digestion (MEC-AD) systems using data collected during a 160-day trial treating brewery wastewater. This study investigated models including decision trees, XGBoost, support vector regression, a variant of support vector machine (SVM), and artificial neural networks (ANNs) for their effectiveness in the soft sensing of system stability. The ANNs demonstrated superior performance, achieving an explained variance of 0.

Targeting both death and paracaspase domains of MALT1 with antisense oligonucleotides overcomes resistance to immune-checkpoint inhibitors.

Targeting MALT1's paracaspase activity has been explored for B cell lymphoma and solid tumors. While the role of MALT1 in promoting cancer cell proliferation has been investigated, its involvement in immune evasion is unclear. Here we report that MALT1 promotes immune evasion through its paracaspase and death domain.

Still a long way to go, the potential of ChatGPT in personalized dietary prescription, from a perspective of a clinical dietitian.

Background: Prominent large language models, such as OpenAI's ChatGPT, have shown promising implementation in the field of nutrition. Special care should be taken when using ChatGPT to prescribe protein restricted diets for kidney impaired patients. The objective of the current study is to simulate a chronic kidney disease (CKD) patient and evaluate the capabilities of ChatGPT in the context of dietary prescription, with a focus on protein contents of the diet.

BEL1-like homeodomain transcription factor SAWTOOTH1 (MdSAW1) in Malus domestica enhances the tolerance of transgenic apple and Arabidopsis to zinc excess stress.

In recent years, the phenomenon of zinc pollution in orchards has become increasingly serious, and the safety of apple production is facing a major risk. Therefore, exploring excellent genes for zinc tolerance has a positive effect on apples. Up to now, there is still a lack of attention on genes related to zinc stress tolerance in apples.

Nicotinamide mononucleotide supplementation ameliorates testicular damage induced by ischemia-reperfusion through reshaping macrophage and neutrophil inflammatory properties.

Background: Ischemia-reperfusion (I/R) injury is the main pathophysiology of testicular torsion-detorsion (T/D). However, there is no safe and effective treatment for testicular I/R injury.

Methods: The levels of NAD related genes were measured in the sham group, I/R + saline-treated group, and I/R + NMN-treated group by quantitative reverse transcription PCR (qRT-PCR).

Evaluation of factors associated with adult skeletal fluorosis in coal-burning type of endemic fluorosis and initial screening model based on machine learning in Guizhou, Southwest China.

Skeletal fluorosis caused by coal-burning type endemic fluorosis greatly affects the health of the population in the affected areas, but large-scale diagnostic work is limited by human and material resources, making it difficult to implement comprehensively. In this study, we investigate adults in coal-burning type endemic skeletal fluorosis areas in Guizhou. The study areas are selected by a comprehensive analysis of the detection rate of dental fluorosis in children aged 8-12 years in Guizhou for the year 2023.

Robust Assessments of Lithium Mining Impacts Embodied in Global Supply Chain Require Spatially Explicit Analyses.

Lithium is a critical material for the energy transition, but its mining causes significant environmental impacts that will intensify due to surging global demand. Here, we conduct a mining site-specific environmental impact assessment of lithium on a global scale, focusing on greenhouse gas (GHG) emissions, water use, and land use. We then track the production and international trade flows of all lithium-containing commodities to assess how lithium mining impacts are distributed across global supply chains.

A Bibliometric Analysis of the Top 100 Most-Cited Articles on Skin Photoaging.

Background: In recent decades, our understanding of the pathogenesis and pathophysiology of skin photoaging has improved considerably, thereby enhancing preventive and management strategies. The bibliometric analysis demonstrates the chronological trends of publications, highlighting the most influential studies related to skin photoaging.

Objective: This study aims to identify and analyze the top 100 most-cited articles related to skin photoaging to offer bibliometric information.

Big data analysis and machine learning of the role of cuproptosis-related long non-coding RNAs (CuLncs) in the prognosis and immune landscape of ovarian cancer.

Background: Ovarian cancer (OC) is a severe malignant tumor with a significant threat to women's health, characterized by a high mortality rate and poor prognosis despite conventional treatments such as cytoreductive surgery and platinum-based chemotherapy. Cuproptosis, a novel form of cell death triggered by copper ion accumulation, has shown potential in cancer therapy, particularly through the involvement of CuLncs. This study aims to identify risk signatures associated with CuLncs in OC, construct a prognostic model, and explore potential therapeutic drugs and the impact of CuLncs on OC cell behavior.