Design, synthesis and agricultural evaluation of derivatives of N-Acyl-N-(m-fluoro-benzyl)-6-amino-coumarin.

ABTRACTThis study aims to design and synthesize a series of N-Acyl-N-(m-fluoro- benzyl)-6- amino-coumarins through the principle of active substructure stitching, which are based on the core structure of N-(m-fluoro-benzyl)-6-amino-coumarin. The structures of target compounds have been characterized by H NMR, C NMR, ESI-MS and elemental analysis. Meanwhile, their agricultural activity have been evaluated in two weeds ( and ) and four widespread noxious pathogens ( and ).

Design, synthesis, antifungal activity, and 3D-QSAR of coumarin derivatives.

In our research, a series of 8-substituted coumarin derivatives were synthesized, and their structures were confirmed by FT-IR, H-NMR, and MS (or HRMS). In activity screening, the synthesized compounds exhibited potent antifungal activity against 4 phytopathogenic fungi: , , , and . Notably, 8-chloro coumarin and ethyl 8-chloro-coumarin3-carboxylate showed the strongest fungus inhibition with EC of 0.

Novel 4-Methylumbelliferone Amide Derivatives: Synthesis, Characterization and Pesticidal Activities.

A series of novel 4-methylumbelliferone amide derivatives were designed, synthesized and characterized by ¹H NMR, C NMR and HR-ESI-MS. The structures of compounds and (compounds named by authors) were further confirmed by X-ray single crystal diffraction. The acaricidal, herbicidal and antifungal activities of the synthesized compounds were assayed for their potential use as pesticide.

New angular oxazole-fused coumarin derivatives: synthesis and biological activities.

Twelve angular oxazole-fused coumarin derivatives were designed, synthesised and characterised by H NMR, C NMR and HRMS. The structure of compound 4a was further confirmed by X-ray single-crystal diffraction. The bioassay experiment results indicated that compounds 4f and 4l have high antifungal activity on the mycelium growth of 4 plant disease fungi.

Hypervalent iodine: a powerful electrophile for asymmetric α-functionalization of carbonyl compounds.

Environmentally friendly hypervalent iodine reagents are unusually effective promoters of asymmetric α-functionalization of carbonyl compounds. By using hypervalent iodine reagents, various substituents can be introduced into the α-position of carbonyl compounds. In the present review, we briefly survey the asymmetric α-functionalization of carbonyl compound reactions catalyzed by these hypervalent iodine reagents.