Publications by authors named "Shuang Wang"

Protein-protein interactions (PPIs) play a crucial role in numerous biochemical and biological processes. Although several structure-based molecular generative models have been developed, PPI interfaces and compounds targeting PPIs exhibit distinct physicochemical properties compared to traditional binding pockets and small-molecule drugs. As a result, generating compounds that effectively target PPIs, particularly by considering PPI complexes or interface hotspot residues, remains a significant challenge.

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Poplar tree growth is frequently hindered by environmental stressors, particularly soil salinization. Enhancing salt tolerance is essential for improving their adaptability and biomass under these conditions. The Stress-Associated Protein (SAP) family, characterized by A20/AN1 zinc finger domains, plays a crucial role in plants' tolerance to abiotic stress.

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Objectives: Ischaemic stroke (IS) has become a major health problem globally as it is one of the leading causes of long-term disability and death. This study aimed to evaluate the association between red cell distribution width (RDW) to lymphocyte (LYM) ratio (RLR) and 30-day mortality risk in patients with IS.

Methods: The present study employed a retrospectively cohort study design with the adult data extracted from the Medical Information Mart for Intensive Care (MIMIC-III, MIMIC-IV) databases between 2001 and 2019.

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Background: Recent phase III randomized controlled trials have demonstrated that first-line immune checkpoint inhibitors (ICIs) improve prognosis in advanced HER-2-negative gastric cancer patients with programmed death ligand 1 (PD-L1) combined positive score (CPS) higher than 5. However, these findings are not confirmed in real-world settings, and the benefits in PD-L1 CPS < 5 patients remain controversial.

Methods: In this multicenter, retrospective cohort study, data from across thirteen medical centers were analyzed by inverse probability of treatment weighting for matching, alongside univariate and multivariate COX proportional hazard regression models.

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This article investigates the impact of visual color perception on fine-grained emotion prediction in videos, analyzing the contribution of color perception features in fine-grained emotion prediction. A total of 20 subjects were involved in this experiment. First, 10 subjects conducted a fine-grained emotional subjective evaluation experiment on 50 video clips.

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Due to their effectiveness at low doses and relative safety for non-target species, plant essential oils (EOs) are considered ideal alternatives to conventional pesticides for pest control. In this study, the chemical composition of () EO was construed by Gas Chromatography-Mass Spectrometry (GC-MS), and its larvicidal and ovicidal activity against omnivorous pests () was assessed. The effects of EO on the activities of antioxidant detoxification enzymes were also measured.

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Greenwashing is the practice of deceiving stakeholders by making inflated or fraudulent promises about environmental responsibility. This study investigates greenwashing challenges in FinTech and banking industries, identifying effective strategies to foster genuine sustainability. The study employs a qualitative methodology, utilizing semi-structured interviews conducted with 12 respondents from the FinTech and banking sectors in Pakistan.

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Nonlinear multimode imaging is a versatile tool to realize complex structural and compositional information of biological samples. In this study, we presented a novel integrated multimode nonlinear optical microscopy system by using an Er3 + -doped femtosecond fiber laser. The system could perform second harmonic generation (SHG), third harmonic generation (THG), and three-photon fluorescence (3PEF) imaging modes simultaneously.

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Mentha haplocalyx Briq. (M. haplocalyx), a notable member of the Lamiaceae family, occupies a significant role in the realm of health foods and botanical medicines.

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B-complex vitamins are essential micronutrients that maintaining health, and provide (individually/simultaneously) many important biological actions in organism. Therefore, sensitive, reliable analytical method to determine B-complex vitamins simultaneously in actual samples is significant. Conventional analytical methods for vitamins analysis are usually labor-intensive, time-consuming and mostly do not allow the simultaneous determination.

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Biomarker detection has emerged as an essential complementary approach for early-stage screening of tumors. Conventional methods are constrained by bulky systems, cumbersome operation steps, and low detection accuracy. Here, we demonstrate a dual-resonance optimally configured lossy mode resonance (LMR) immunoprobe for detecting prostate-specific antigen (PSA), a biomarker for prostate cancer (PCa).

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The subiculum represents a crucial brain pivot in regulating seizure generalization in temporal lobe epilepsy (TLE), primarily through synergy of local GABAergic and long-projecting glutamatergic signaling. However, little is known about how subicular GABAergic interneurons are involved in a cell-type-specific way. Here, employing Ca fiber photometry, retrograde monosynaptic viral tracing and chemogenetics in epilepsy models of both male and female mice, we elucidate circuit reorganization patterns mediated by subicular cell-type-specific interneurons and delineate their functional disparities in seizure modulation in TLE.

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Article Synopsis
  • Histomonosis is a protozoan disease that affects poultry and causes significant economic losses in China, prompting the development of an attenuated vaccine based on a less virulent strain.
  • Four experiments were conducted to test the viability of the attenuated strain, including comparing different infection routes, doses, and immunization schedules to determine the most effective vaccination strategy.
  • Results indicated that the intracloacal route was more effective than oral administration, particularly with a vaccination dose of 2 × 10 on day 14, which led to better weight gain and fewer health issues in vaccinated chickens.
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Papillary thyroid cancer (PTC) is an increasingly prevalent endocrine malignancy, with a subset exhibiting aggressive features such as lymphatic metastasis and resistance to iodine therapy. Recent studies suggest that circular RNAs (circRNAs) play a significant role in PTC pathology. High throughput circRNA sequencing identified circRNA_14580 as notably upregulated in PTC tissues.

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In this study, we investigated how the composition and population of rumen microbiota shifted in response to diurnal oscillations under 2 different diets (high grain vs. high forage). Five multiparous Holstein dairy cows with similar BW, DIM, and parity were enrolled in this study.

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Rationale And Objectives: To evaluate the performance of virtual MR elastography (vMRE) for predicting microvascular invasion (MVI) in Barcelona Clinic Liver Cancer (BCLC) stage A (≤ 5.0 cm) hepatocellular carcinoma (HCC) and to construct a combined nomogram based on vMRE, multi-b-value DWI models, and clinical-radiological (CR) features.

Methods: Consecutive patients with suspected HCC who underwent multi-b-value DWI examinations were prospectively collected.

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We theoretically and experimentally carried out an inspired type of toroidal dipole (TD) metasurfaces, which composed of a metamolecule of symmetric aluminium semicircles with a bar in the middle fabricated on polyimide substrate in the terahertz (THz) regime. It was found that the three resonances show red-shift tendency due to the increase of inductance and capacitance with the increase of semicircle's outer radius. Meanwhile, both the TD resonances and the current flowing in the metallic bar can generate the head-to-tail magnetic field distribution, which is the most prominent feature of TD phenomenon.

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Article Synopsis
  • This study aimed to understand the varying symptoms of perimenopause by using advanced statistical methods to create a comprehensive assessment framework that combines multiple scales related to insomnia, anxiety, and depression.
  • A clinical study in Guangzhou enrolled 336 perimenopausal patients, and a framework was developed to identify six factors affecting their experience, such as sleep disturbance and fatigue, validated through psychometric analysis.
  • The findings suggested four distinct profiles of perimenopause symptoms, highlighting the complex and varied nature of the condition across different individuals.
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Powering and communicating with wearable devices on bio-interfaces is challenging due to strict weight, size, and resource constraints. This study presents a sunflower-like plant-wearable sensing device that harnesses solar energy, achieving complete energy self-sustainability for long-term monitoring of plant sap flow, a crucial indicator of plant health. It features foldable solar panels along with all essential flexible electronic components, resulting in a compact system that is lightweight enough for small plants.

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Understanding the puff-by-puff delivery mechanisms of key components of heated tobacco products is critical to developing product designs. This study investigates the puff-by-puff release patterns of key components in Natural Smoke Cigarettes (NSCs), which are designed to deliver nicotine without combustion by reducing oxygen content, utilizing a 30-s puff interval, a 2-s puff duration, and a 55 mL puff volume to simulate realistic smoking conditions. By establishing models to analyze the variation of nicotine, glycerol, 1,2-propylene glycol (PG), and water in different functional sections of the cigarette under controlled smoking conditions.

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