Vanadium single-atoms coordinated artificial peroxidases as biocatalyst-linked immunosorbent assay for highly-sensitive carcinoembryonic antigen immunoassay.

In medical and biomedical fields, enzyme-mimetic nanomaterials have garnered significant interest as efficacious signal enhancers for biocatalyst-linked immunosorbent assays (BLISA). Despite the burgeoning enthusiasm, engineering artificial biocatalysts that exhibit both exceptional catalytic proficiency and pronounced colorimetric signal output remains a formidable challenge. Inspired by the heme structures and biocatalytic activities of horseradish peroxidase, we introduce the synthesis of vanadium single-atoms (SAV) coordinated artificial peroxidases as BLISA for highly sensitive and selective carcinoembryonic antigen (CEA) immunoassay.

Learning curve for the perinatal outcomes of radiofrequency ablation for selective fetal reduction: a single-center, 10-year experience from 2013 to 2023.

Objectives: To investigate the perinatal outcomes of SR using radiofrequency ablation (RFA) in MC pregnancies, identified factors affecting these outcomes, and assessed the associated learning curve.

Methods: This retrospective cohort study included all consecutive MC pregnancies that required RFA from September 2013 to April 2023 at our institution. The perinatal outcomes were compared on the basis of various indications, and binary logistic regression analysis was performed to identify the risk factors for cotwin loss.

Preparation of molecular imprinted fluorescence sensor based on Er3+/ZnS QDs and its selective detection of ciprofloxacin in various matrices.

Background: Ciprofloxacin is a widely used antibiotic in medicine and agriculture. It can cause pollution to the environment and food, thereby affecting human health.

Objective: This study proposes the preparation of molecular imprinted fluorescent sensors and their selective detection of ciprofloxacin, with the aim of achieving specific recognition and accurate detection of ciprofloxacin.

Enhanced Conductivity in Conjugated Microporous Polymers via Integrating of Carbon Nanotubes for Ultrasensitive NO Chemiresistive Sensor.

Conjugated microporous polymers (CMPs) present high promise for chemiresistive gas sensing owing to their inherent porosities, high surface areas, and tunable semiconducting properties. However, the poor conductivity hinders their widespread application in chemiresistive sensing. In this work, three typical CMPs (PSATA, PSATB, and PSATT) are synthesized and their chemiresistive gas sensing performance is investigated for the first time.

The Value of Diffusion Tensor Imaging in Differential Diagnosis of Embryonal Tumors Occurring in the Brainstem and Brainstem Gliomas in Pediatric Patients.

Background: There are no apparent distinctions in clinical presentation or conventional imaging findings between brainstem gliomas and embryonal tumors occurring in the brainstem. Our aim was to study the role of diffusion tensor imaging in differentiating embryonal tumors from gliomas of the brainstem.

Methods: Three cases of embryonal tumors occurring in the brainstem and 19 cases of brainstem gliomas were analyzed retrospectively.

Length-dependent water permeation through a graphene channel.

Water confined in two-dimensional channels exhibits unique properties, such as rich morphology, specific phase transition and a low dielectric constant. In this work, molecular dynamics simulations have been used to study the water transport in two-dimensional graphene channels. The structures and dynamics of water under confinement show strong dependence on the channel length and thickness of the channels.

Green Synthesis of Silver Nanoparticles (CM-AgNPs) from the Root of for Improving the Cytotoxicity Effect in Cancer Cells with Antibacterial and Antioxidant Activities.

The unique properties of silver nanoparticles (AgNPs), such as size, surface charge, and the ability to release silver ions, contribute to DNA damage, inducing of oxidative stress, and apoptosis in cancer cells. Thus, the potential application of AgNPs in the field of biomedicine, and cancer therapy are rapidly increasing day by day. Therefore, in this study, AgNPs were synthesized by extract of , and then the synthesized CM-AgNPs were fully characterized.

Multi-Feature Fusion for Estimating Above-Ground Biomass of Potato by UAV Remote Sensing.

Timely and accurate monitoring of above-ground biomass (AGB) is of great significance for indicating crop growth status, predicting yield, and assessing carbon dynamics. Compared with the traditional time-consuming and laborious method through destructive sampling, UAV remote sensing provides a timely and efficient strategy for estimating biomass. However, the universality of remote sensing retrieval models with multi-feature fusion under different management practices and cultivars are unknown.

Draft genome sequence of ATCC15233.

is a well-studied polyextremotolerant generalist fungus with a ubiquitous distribution, which can efficiently secret extracellular polysaccharides, especially pullulan. Here, we reported the draft genome of ATCC15233, whose genome length is 30,444,007 bp, with a GC content of 50.63%.

Estrogen Receptor β Alleviates Colitis by Inhibiting Ferroptosis in Intestinal Epithelial Cells.

Background: Ulcerative colitis (UC), a major type of inflammatory bowel disease, is characterized by chronic inflammation of the colonic mucosa and submucosa. Estrogen receptor β (ERβ) predominates in the colon and exerts anti-inflammatory effects. Ferroptosis, a recently discovered form of iron-dependent programmed cell death, is implicated in the pathogenesis of several diseases, including UC.

Mitochondrial transplantation rescues Ca homeostasis imbalance and myocardial hypertrophy in SLC25A3-related hypertrophic cardiomyopathy.

SLC25A3 encodes mitochondrial phosphate carrier (PiC), which is involved in inorganic phosphate transport. Clinical reports have found that most patients with homozygous or complex heterozygous mutations in SLC25A3 exhibit lactic acidosis, cardiac hypertrophy, and premature death. However, the potential molecular mechanisms underlying these associations remain unclear.

PEG-modification enhances the targeted photothermal therapy of affibody-conjugated indocyanine green for precision cancer treatment.

Photothermal therapy (PTT) is an innovative cancer treatment that leverages heat generated from near-infrared light exposure to induce tumor cell death. A major challenge in PTT is achieving precise delivery of the photothermal agent to tumor tissues to maximize efficacy and minimize off-target effects. In this study, we introduce a novel ligand-coupled photothermal reagent that addresses this challenge by leveraging the high-affinity HER2 affibody Z (referred to as Z), conjugated with indocyanine green (ICG) for targeted delivery.

Double-Walled Carbon Nanotubes Enable Breakdown of the Trade-off between Ion Selectivity and Water Permeability.

Although evidence has been presented for desalination potentials in single-walled carbon nanotubes (SWCNTs), it is still very challenging to overcome the trade-off between ion selectivity and water permeability by simply tuning the carbon nanotube (CNT) size. In this work, we prove that double-walled carbon nanotubes (DWCNTs) can make it. Employing a series of molecular dynamics simulations, we find a striking phenomenon that tuning the combination architecture of DWCNTs can significantly improve the desalination performance, with the salt rejection rate even reaching 100% in some cases while maintaining high levels of water flux.

Photo-controlled cascade DNA hybridization for amplified electrochemical biosensor with tunable sensing performance.

Background: Precise control of the biorecognition process in DNA biosensors, especially for those with signal amplification, remains a challenge. It is of great significance to introduce external stimuli into the DNA system for a controllable trigger of nucleic acid cascade amplification and further for excellent biosensors.

Results: In this study, a photo-initiated hybridization chain reaction (HCR) was designed for controllable and sensitive electrochemical biosensor via the incorporation of azobenzene moiety into the assembly unit.

One stone two birds: NH-UiO-66@MB-based bimodal aptasensor for sensitive and rapid detection of zearalenone in cereal products.

Zearalenone (ZEN), a prevalent mycotoxin found in cereal crops, poses a significant threat to food safety and human health. To address this issue, there is an urgent need for rapid, sensitive, and cost-effective detection methods. In this study, we developed a novel bimodal aptasensor based on NH-UiO-66@MB composites for ZEN detection.

An All-Passive and Macropatterned Architecture Design for Water Harvesting.

Solar evaporation designs show great promise in water harvesting without electricity inputs. Unfortunately, they have been heavily limited by a low water yield. To overcome this challenge, we introduced a new architecture featuring both system-level and materials-level designs.

Epigenetic regulation of lignin biosynthesis in wood formation.

Lignin, a major wood component, is the key limiting factor for wood conversion efficiency. Its biosynthesis is controlled by transcriptional regulatory networks involving transcription factor (TF)-DNA interactions. However, the epigenetic mechanisms underlying these interactions in lignin biosynthesis remain largely unknown.

FMRFamide G protein-coupled receptors (GPCR) in the cuttlefish Sepiella japonica: Identification, characterization and expression profile.

FMRFamide is a ubiquitous neuromodulator in the animal kingdom. Once FMRFamide or similar neuropeptides bind to their G protein-coupled receptors (GPCR), a series of signal transduction events are triggered, thereby mediating various physiological effects. FMRFamide had been reported to be involved in the regulation of sexual maturation in Sepiella japonica.

Topological transformation of synthetic ferromagnetic skyrmions: thermal assisted switching of helicity by spin-orbit torque.

This study demonstrates the controllable switching of skyrmion helicity using spin-orbit torque, enhanced by thermal effects. Electric current pulses applied to a [Pt/Co]/Ru/[Co/Pt] multilayer stripe drive skyrmions in a direction opposite to the current flow. Continuous pulsing results in an unexpected reversal of skyrmion motion.

Exploring aggressive emotions in women in prison: the role of empathy and perceived social support in moderating the effects of childhood discrimination experiences.

Background: The recent increase in the population of women in prison within the societal context of China has shifted attention towards understanding the unique psychological and social dynamics distinct from those traditionally associated with man offenders. Growing evidence suggests that childhood experiences of discrimination play a crucial role in shaping the aggressive behaviors observed among women in prison. This underscores the necessity for an in-depth examination of the psychological and societal foundations of these behaviors.