Publications by authors named "Shuang Lan"

Article Synopsis
  • * The huR83C mouse model replicates the disease phenotype and has been used to test the effectiveness of BEAM-301, a treatment that utilizes lipid nanoparticles and adenine base editing to correct the harmful G6PC1-R83C variant.
  • * BEAM-301 has shown the ability to correct about 60% of the variant in liver cells, restore blood sugar control, improve overall health, and increase survival rates in mice, indicating its potential as a therapeutic option for patients with this specific genetic mutation
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The development of low-porosity and low-permeability oil reservoirs in the Changqing oilfield presents a significant challenge due to the high injection pressure and limited space for profile control and pressure raising. Therefore, the synergistic profile control and flooding technology of polymer microspheres (PMs) and nanoemulsions is proposed, which makes use of the plugging performance of PMs and the pressure-reducing and oil-driving properties of nanoemulsions, with the objective of controlling the water-absorbing profile and increasing the recovery rate. The paper assessed the properties of nanoemulsions and PMs and evaluated their suitability for reservoirs.

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Objective: Given high risks of major bleeding during retroperitoneal sarcoma(RPS) surgeries, severe complications and deaths are common to see perioperatively. Thus, effective anesthetic management is the key point to ensuring the safety of patients. This study aimed to introduce anesthesia management and mortalities in RPS patients receiving massive blood transfusions during surgeries.

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Chronic hepatitis B virus (HBV) infection remains a global health problem due to the lack of treatments that prevent viral rebound from HBV covalently closed circular (ccc)DNA. In addition, HBV DNA integrates in the human genome, serving as a source of hepatitis B surface antigen (HBsAg) expression, which impairs anti-HBV immune responses. Cytosine base editors (CBEs) enable precise conversion of a cytosine into a thymine within DNA.

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The sludge fermentation-driven biological nitrogen removal (SFBNR) has garnered increasing attention due to its efficient carbon resource utilization from waste activated sludge (WAS). This study successfully extended the application of this technique to a 38 m reactor, facilitating a daily ultra-low carbon to nitrogen ratio (<1) wastewater treatment capacity of 16 tons and a WAS capacity of 500 L. After 185-days operation, the system demonstrated commendable performance with a denitrification efficiency (DNE) of 93.

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Background: To describe and report the efficacy and safety of MR-guided laser interstitial thermal therapy (MRgLITT) in the treatment of drug-resistant epilepsy.

Methods: A retrospective review of all MRgLITT procedures in our hospital was performed. All procedures were performed using a surgical laser ablation system.

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Purpose: We sought to reveal the clinical characteristics of lateral ventricle tumors and to evaluate the superior surgical procedure available.

Methods: There involved a total of of 49 adult patients harboring lateral ventricle tumors in neurosurgery department of our hospital from January 2016 to March 2022. The patients enrolled were retrospectively analyzed, so are their clinical manifestations, pathological characteristics and surgical strategies.

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Article Synopsis
  • The internal electric field in piezoelectric materials can help prevent the recombination of electron-hole pairs, boosting photocatalytic efficiency.
  • A NaBiTiO (NBT) catalyst was created using a hydrothermal method and had its performance improved through high-voltage poling.
  • The 2 kV mm poled NBT sample achieved nearly complete degradation of Rhodamine B in 120 minutes, with a reaction rate constant significantly higher than that of the unpoled sample, highlighting the potential for enhanced piezo-photocatalytic applications in environmental cleanup.
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To improve resolution to small genomic regions and sensitivity to small-effect loci in the identification of genetic factors conferring the enlarged inflorescence and other traits of cauliflower while also expediting further genetic dissection, 104 near-isogenic introgression lines (NIILs) covering 78.56% of the cauliflower genome, were selected from an advanced backcross population using cauliflower [Brassica oleracea var. botrytis L.

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The long-term impact of fulvic acid (FA) on partial nitritation (PN) system was initially examined in this study. The obtained results revealed that the FA lower than 50 mg/L had negligible effect on the nitrite accumulation rate (NAR nearly 100%) and ammonium removal rate (ARR 56.85%), while FA over 50 mg/L decreased ARR from 56.

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The mechanisms of Fe on nitrogen and phosphorus removal and functional bacterial competition in anammox systems was investigated. Under 0.12 mM Fe, the performance of nitrogen and phosphorus removal increased by 10.

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In this study, a novel strategy of zero-valent iron (ZVI) combined with acetic acid was proposed to optimize partial-denitrification/anammox (PD/A) process, and enhanced nitrogen removal mechanism was elucidated through metagenomics. Results showed that the optimal nitrogen and phosphorus removal were as high as 99.50% and 98.

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The complex relationships between the molecular composition of dissolved organic matter (DOM) and microbial communities are essential for maintaining the stability of aquatic ecosystems. This study comprehensively analyzed the characteristics and potential effects of DOM molecular composition as well as the relationship between microbial communities and DOM molecular composition in sediments from the Beiyun River, Beijing, China. The results showed that the content of DOM in Beiyun River sediments was 9.

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The zero-valent iron-anaerobic ammonium oxidation (ZVI-anammox) system has received widespread attention due to its excellent nitrogen removal performance and user-friendly operation. However, its disadvantages include a short service life, high ZVI consumption, and poor system stability. The use of ultrasound as a physical method is increasing in various water treatment processes.

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In this study, a novel process, anammox-synchronous zero-valent iron (ZVI) oxidationin whichnitrate byproductsare usedfor in situoxidization of ZVIwas first developed to simultaneously remove nitrogen and phosphorus from wastewater. The optimal ZVI dosage of 4 g/L significantly improved the nitrogen removal efficiency to 86.02 ± 1.

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The rapid start-up of Partial denitrification (PD; nitrate to nitrite) was investigated based on the analysis of microbially driven mechanism of nitrite accumulation mediated by Dissolved organic matter (DOM) in this study. The nitrate to Nitrite transformation ratio (NTR) > 90% and effluent nitrate < 5 mg/L were achieved in 17 days by feeding with lower nitrate of ~ 35 mg/L and removing the idling period. And the enhanced nitrite accumulation when applying the above strategy is related to the decreased utilization of the aliphatic DOM during nitrite reduction process.

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Article Synopsis
  • The study examines the genetic factors influencing flowering time in Brassica napus, using a recombinant inbred line (RIL) population across six different environments.
  • Researchers discovered 27 quantitative trait loci (QTLs), with a significant QTL on chromosome C02 explaining a notable portion of the variation in flowering time across all environments.
  • RNA-Seq analysis identified 105 differentially expressed genes (DEGs) related to flowering time, with 45 of these genes located in QTL regions, including important genes like PSEUDO RESPONSE REGULATOR 7 (PRR7) and FY.
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Synopsis of recent research by authors named "Shuang Lan"

  • - Shuang Lan's research primarily focuses on advancing methodologies in environmental engineering and medical management, particularly addressing issues related to wastewater treatment, oil recovery, and surgical procedures.
  • - Recent studies include the synergistic use of polymeric microspheres and nanoemulsions in oil reservoir management, enhanced piezo-photocatalytic performance for wastewater degradation, and comprehensive analysis of blood transfusion impacts during complex surgeries.
  • - Additionally, Lan explores innovative techniques in genomics related to crops, such as genetic dissection of cauliflower traits, and investigates microbial mechanisms in nitrogen and phosphorus removal processes, contributing valuable insights to both agricultural and environmental sciences.

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