Publications by authors named "Shuang Gu"

Naked-neck chickens are distributed across tropical and subtropical regions and exhibit notable resistance to heat stress. The naked-neck trait in chickens is an incompletely dominant characteristic determined by the Na gene, and significant differences in feather quantity and distribution have been observed between homozygous and heterozygous individuals. The Ake chicken, a native Chinese breed originating from southwestern Yunnan Province, is the only breed in China that possesses the naked-neck trait.

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The Mediator complex (MED) functions as a co-activator in plants, transmitting transcriptional signals to regulate gene expression, including responses to environmental stresses. While the MED gene family has been identified in several species, it has not yet been reported in cassava. In this study, we identified 32 members of the gene family in cassava ( Crantz) distributed across 13 chromosomes.

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Carbon source is an important nutrient for bacteria to sustain growth and often acts as a signal that modulates virulence expression. L-arabinose is produced by plants and plays an important role in regulating the global gene expression of bacteria. Previously, we have shown that L-arabinose induces a more severe systemic infection in -infected mice with normal microbiota, but does not affect the disease progression in mice with microbiota depleted by antibiotic treatment.

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Skeletal muscle fiber characteristics are pivotal in assessing meat quality. However, there is currently a lack of research precisely quantifying the total number of myofibers (TNM) of skeletal muscles. This study used Arbor Acres (AA) broilers and Wenchang (WC) chickens to determine the TNM of several skeletal muscles and the meat quality of the pectoralis major muscle (PM).

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Background: At present, few articles compare the differences between robot-assisted thoracic surgeries (RATSs) and video-assisted thoracic surgeries (VATSs) in the day surgery model and there is also little literature on what factors influence delayed discharge from day surgery. This study aims to compare short-term outcomes between RATS and VATS for segmental lung resection in a day surgery setting, and to identify risk factors for delayed discharge.

Methods: A retrospective analysis was performed on 204 patients with early-stage non-small-cell lung cancer (NSCLC) who underwent segmental lung resection via RATS or VATS at the First People's Hospital of Changzhou City from January 2021 to December 2023.

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The movement of biological swarms is widespread in nature, and collective behavior enhances a swarm's adaptability to its environment. However, most research focuses on free swarm movement, overlooking the impact of environmental constraints such as tubes. This study examines the swimming behavior of Petitella georgiae through a tube.

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Objective: To explore the clinical value of computed tomography (CT) liver-to-spleen (L/S) attenuation ratio in patients with non-alcoholic fatty liver disease (NAFLD) accompanied by atherosclerotic plaque (AP).

Methods: This was a single-center, retrospective, observational study of patients who were diagnosed with NAFLD undergoing CT scans at Beijing Changping Hospital of Chinese Medicine from April 2020 to April 2022. Patients were grouped according to whether they had a diagnosis of AP or not.

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Article Synopsis
  • A new method using palladium as a catalyst has been created for a [3 + 2] cycloaddition reaction involving 4-vinyl-4-butyrolactones and alkenes.
  • This method produces a variety of spirocyclopentane compounds with high yields and great selectivity for different molecular arrangements.
  • The reaction has been successfully scaled up and further modified, indicating its usefulness in organic chemistry applications.
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  • Feed efficiency is a key economic trait in the poultry industry, influenced by both the genetics of the hosts (like laying hens) and their gut microbiota, but the exact relationships are not well understood.
  • A comprehensive study involving 686 laying hens utilized various genetic and microbiome sequencing techniques to analyze the impact of genetic variations and microbiota on feed efficiency, discovering that different gut areas contribute varying degrees to feed conversion ratio (FCR) and residual feed intake (RFI) variance.
  • Four specific genes (SUCLA2, TNFSF13B, SERTM1, and MARVELD3) were linked to feed efficiency through genetic analysis, with particular gut bacteria abundances identified as indicators of better feed efficiency,
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Hypertension is one of the main risk factors for cardiovascular disease and causes widespread morbidity and mortality worldwide. The aim of this work was to screen the fruit with high angiotensin I-converting enzyme (ACE) inhibitory activity and kallikrein (KLK) promotion activity by three different extraction methods from 22 kinds of fruits. Results showed that the aqueous extracts of fresh kiwifruit significantly inhibited ACE activity (47.

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Nucleic acids, because of their precise pairing and simple composition, have emerged as excellent materials for the formation of gels. The application of DNA hydrogels in the diagnosis and therapy of cancer has expanded significantly through research on the properties and functions of nucleic acids. Functional nucleic acids (FNAs) such as aptamers, Small interfering RNA (siRNA), and DNAzymes have been incorporated into DNA hydrogels to enhance their diagnostic and therapeutic capabilities.

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Article Synopsis
  • * A study analyzed 274 male broilers, tracking weekly feed intake (FI) and body weight to identify three distinct FI patterns, with most broilers falling into an increase-then-plateau pattern.
  • * Results showed that broilers maintaining continuous increase in FI had better growth performance and feed efficiency, highlighting the need to focus on appetite in final stages of production.
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Background: Broilers stand out as one of the fastest-growing livestock globally, making a substantial contribution to animal meat production. However, the molecular and epigenetic mechanisms underlying the rapid growth and development of broiler chickens are still unclear. This study aims to explore muscle development patterns and regulatory networks during the postnatal rapid growth phase of fast-growing broilers.

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Heterosis has been widely utilized in agricultural production. Despite over a century of extensive research, the underlying mechanisms of heterosis remain elusive. Most hypotheses and research have focused on the genetic basis of heterosis.

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Article Synopsis
  • Long-term genetic selection has created distinct differences in muscle fiber development between broiler (meat) and layer (egg) chickens, particularly noticeable during their embryonic stages, specifically by day 17 (E17), when muscle fiber formation occurs.
  • The study analyzed gene expression and chromatin accessibility in the pectoral muscles of Cornish and White Plymouth Rock broilers, and White Leghorn layers, revealing that broilers had significantly greater embryonic and muscle weights at E17, with numerous differentially expressed genes identified across the groups.
  • Key findings included the identification of specific upregulated genes like GOLM1 and MYOM3 that are associated with immune functions and muscle
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Article Synopsis
  • * Encapsulation peptides, which help target enzymes to these microcompartments, are shown to bind to a specific groove formed by the shell proteins, aiding in shell assembly.
  • * Understanding how these peptides bind provides insight into the microcompartments' structure and function, potentially leading to applications in bioengineering or disease prevention.
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Ethylene produced by plants generally induces ripening and promotes decay, whereas the effect of ethylene produced by pathogens on plant diseases remains unclear. In this study, four ethylene-producing fungi including Alternaria alternata (A. alternata, Aa), Fusarium verticilliodes (F.

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A glut of dinitrogen-derived ammonia (NH) over the past century has resulted in a heavily imbalanced nitrogen cycle and consequently, the large-scale accumulation of reactive nitrogen such as nitrates in our ecosystems has led to detrimental environmental issues. Electrocatalytic upcycling of waste nitrogen back into NH holds promise in mitigating these environmental impacts and reducing reliance on the energy-intensive Haber-Bosch process. Herein, we report a high-performance electrolyzer using an ultrahigh alkalinity electrolyte, NaOH-KOH-HO, for low-cost NH electrosynthesis.

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Article Synopsis
  • - This study addresses the limitations of current methods for counting muscle fibers by creating a large dataset of over 660,000 manually and semiautomatically labeled muscle fibers.
  • - The researchers developed an automated tool called MyoV using advanced neural networks, which shows excellent performance in detecting and quantifying muscle fibers, achieving detection rates of 0.93-0.96 and precision levels of 0.91-0.97, outperforming traditional methods and software.
  • - MyoV can analyze muscle fibers from various species, including mice and agricultural animals, and is integrated into user-friendly visualization software that allows for efficient processing and labeling of muscle fibers from whole slide images (WSIs), making it accessible for researchers.
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Animal breeding has made great genetic progress in increasing carcass weight and meat yield in recent decades. However, these improvements have come at the expense of meat quality. As the demand for meat quantity continues to rise, the meat industry faces the great challenge of maintaining and even increasing product quality.

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  • Rice is sensitive to cold stress, which negatively impacts its yield and quality, and the genetic mechanisms for cold adaptation are not fully understood.
  • Researchers found two specific genetic variations in a gene (OsSEH1) that may help the japonica subspecies of rice adapt better to cold compared to the indica subspecies.
  • The study reveals that a transgenic japonica line shows improved cold tolerance by regulating certain genes, which helps manage stress-related processes and could aid in breeding cold-resistant rice varieties.
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Objective: To explore the mechanism of circular RNA (circRNA)-AnnexinA7 (ANXA7) in non-small cell lung cancer (NSCLC) cisplatin (DDP) resistance through microRNA (miR)-545-3p to target Cyclin D1 (CCND1).

Methods: DDP-resistant and non-resistant NSCLC tissues and normal tissues were collected. DDP-resistant cells (A549/DDP and H460/DDP) were constructed.

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  • Intramuscular fat (IMF) is a key factor in meat quality and can potentially be influenced by gut microbiota in chickens.
  • A study of 206 cecal samples from high-quality broilers identified two distinct microbial communities (enterotypes) that differed in diversity and fat deposition, with one enterotype showing significantly greater fat levels.
  • The research found a correlation between IMF content in different muscle tissues and identified specific microorganisms, suggesting that managing gut microbiota could improve meat quality by regulating IMF levels.
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Background: Embryonic diapause (dormancy) is a state of temporary arrest of embryonic development that is triggered by unfavorable conditions and serves as an evolutionary strategy to ensure reproductive survival. Unlike maternally-controlled embryonic diapause in mammals, chicken embryonic diapause is critically dependent on the environmental temperature. However, the molecular control of diapause in avian species remains largely uncharacterized.

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