Hepatosplenic gammadelta T-cell lymphoma.

Aim: To investigate the clinicopathologic characteristics, immunophenotype and TCR gene rearrangements of hepatosplenic T-cell lymphoma in eight Chinese patients.

Methods: Eight Chinese patients with hepatosplenic gammadelta T-cell lymphomas were studied. Hematoxylin-eosin-stained slides and clinical histories were reviewed.

[Expression of survivin gene in pancreatic carcinoma].

Objective: To determine the expression status of survivin gene in pancreatic carcinoma.

Methods: Expression of survivin gene was evaluated by immunohistochemistry, Western Blot and RT-PCR in 59 cases of pancreatic carcinoma along with their corresponding adjacent benign tissues, 11 cases of chronic pancreatitis, and 7 pancreatic carcinoma cell lines.

Results: The positive expression rate of survivin in pancreatic carcinoma was 72.

[Thyrotropin-secreting pituitary adenoma:a clinicopathological analysis of seven cases].

Objective: To study the clinicopathological features of thyrotropin-secreting pituitary adenoma (TSH adenoma).

Methods: Clinical and pathological features of 7 TSH adenoma cases were studied by review of patients' medical records, light and electronic microscopy, and immunohistochemistry.

Results: All seven patients presented with clinical hyperthyroidism and high levels of plasma free T3, free T4, total T3 and total T4.

[Distinction between benign and malignant pheochromocytomas].

Objectives: To investigate the differences in morphology, immunohistochemistry, DNA ploidy status, LOH and MSI of 11q13 and 1p between benign and malignant pheochromocytomas, and to find the marker or markers useful in distinction between benign and malignant pheochromocytoma or for predicting the malignant potential of this tumor.

Methods: Twenty-two cases of clinically documented benign and malignant pheochromocytomas from the files of Peking Union Medical College Hospital were analyzed. Aside from histological study, Ki-67, p53, CgA, S-100, PCNA and survivin immunohistochemistry studies were performed.